ES8501443A1 - Un metodo de ensayo de diagnostico para detectar una toxina bacteriana - Google Patents

Un metodo de ensayo de diagnostico para detectar una toxina bacteriana

Info

Publication number
ES8501443A1
ES8501443A1 ES530852A ES530852A ES8501443A1 ES 8501443 A1 ES8501443 A1 ES 8501443A1 ES 530852 A ES530852 A ES 530852A ES 530852 A ES530852 A ES 530852A ES 8501443 A1 ES8501443 A1 ES 8501443A1
Authority
ES
Spain
Prior art keywords
bacterial toxin
detecting
test method
diagnostic test
toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530852A
Other languages
English (en)
Other versions
ES530852A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Rochester
Original Assignee
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Rochester filed Critical University of Rochester
Publication of ES530852A0 publication Critical patent/ES530852A0/es
Publication of ES8501443A1 publication Critical patent/ES8501443A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1285—Gram-positive bacteria from Corynebacterium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

METODO DE ENSAYO DE DIAGNOSTICO PARA DETECTAR UNA TOXINA BACTERIANA.COMPRENDE LAS ETAPAS DE: A) MEZCLAR UNA MUESTRA BIOLOGICA HUMANA CON ANTICUERPOS CONTRA UNA TOXINA BACTERIANA PRODUCIDA POR UN HIBRIDO DE CELULAS FUSIONADAS FORMADO FUSIONANDO (I) UNA CELULA HUMANA CAPAZ DE PRODUCIR ANTICUERPOS CONTRA UNA TOXINA BACTERIANA Y (II) UNA CELULA DE MIELOMA, Y B) DETECTAR LA INTERACCION DE DICHA MUESTRA BIOLOGICA Y DICHOS ANTICUERPOS. LA TOXINA BACTERIANA PUEDE SER UNA EXOTOXINA, UNA ENDOTOXINA O LA TOXINA DEL TETANOS Y LA MUESTRA BIOLOGICA SUERO.
ES530852A 1982-09-30 1984-03-22 Un metodo de ensayo de diagnostico para detectar una toxina bacteriana Expired ES8501443A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42874782A 1982-09-30 1982-09-30

Publications (2)

Publication Number Publication Date
ES530852A0 ES530852A0 (es) 1984-11-16
ES8501443A1 true ES8501443A1 (es) 1984-11-16

Family

ID=23700239

Family Applications (3)

Application Number Title Priority Date Filing Date
ES526097A Expired ES8600057A1 (es) 1982-09-30 1983-09-29 Un procedimiento para obtener anticuerpos monoclonales humanos contra toxina bacteriana
ES530852A Expired ES8501443A1 (es) 1982-09-30 1984-03-22 Un metodo de ensayo de diagnostico para detectar una toxina bacteriana
ES530853A Expired ES8604421A1 (es) 1982-09-30 1984-03-22 Un metodo para separar una toxina bacteriana de una muestra biologica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES526097A Expired ES8600057A1 (es) 1982-09-30 1983-09-29 Un procedimiento para obtener anticuerpos monoclonales humanos contra toxina bacteriana

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES530853A Expired ES8604421A1 (es) 1982-09-30 1984-03-22 Un metodo para separar una toxina bacteriana de una muestra biologica

Country Status (8)

Country Link
EP (2) EP0105804B1 (es)
AT (1) ATE70309T1 (es)
AU (1) AU567693B2 (es)
CA (1) CA1262238A (es)
DE (1) DE3382474D1 (es)
DK (1) DK450183A (es)
ES (3) ES8600057A1 (es)
IE (1) IE60439B1 (es)

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FI853395A7 (fi) * 1984-09-05 1986-03-06 Cetus Corp Monoklonaaliset vasta-aineet, jotka salpaavat gram-negatiivista bakteeriendotoksiinia.
JP2691708B2 (ja) * 1984-09-26 1997-12-17 住友製薬株式会社 ヒトモノクローナル抗体およびその製法
GB8426463D0 (en) * 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
GB8426464D0 (en) * 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
GB8426470D0 (en) * 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
AU597877B2 (en) * 1984-12-26 1990-06-14 Teijin Limited Anti-pseudomonas aeruginosa human monoclonal antibody
US4818687A (en) * 1985-02-28 1989-04-04 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
US4677070A (en) * 1985-04-26 1987-06-30 Cetus Corporation Pseudomonas aeruginosa exotoxin A antibodies, their preparation and use
HU205630B (en) * 1985-06-06 1992-05-28 Genetic Systems Corp Process for producing monoclonal antibodys inhibiting exotoxine and toxic effect of pseudomonas aeruginosa and specific for them, celle lines producing them and pharmaceutical compositions
IL81370A (en) * 1986-02-07 1991-06-30 Genetic Systems Corp Pharmaceutical and diagnostic compositions comprising a plurality of human monoclonal antibodies for the treatment of bacterial diseases,methods for the preparation of the compositions and antibodies and kits containing said compositions
USRE35862E (en) * 1986-08-18 1998-07-28 Emisphere Technologies, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5541155A (en) 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5447728A (en) * 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5451410A (en) * 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5578323A (en) * 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5401516A (en) 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
BR9604880A (pt) 1995-03-31 1998-05-19 Emisphere Tech Inc Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US5824345A (en) 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
WO1997010197A1 (en) 1995-09-11 1997-03-20 Emisphere Technologies, Inc. METHOD FOR PREPARING φ-AMINOALKANOIC ACID DERIVATIVES FROM CYCLOALKANONES
SI9720025A (sl) 1996-03-29 1999-08-31 Emishphere Technologies, Inc. Spojine in sestavki za prenos aktivne snovi
CA2258264A1 (en) 1996-06-14 1997-12-18 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
WO2018078643A1 (en) * 2016-10-26 2018-05-03 Bharat Serums And Vaccines Ltd. Monoclonal antibodies neutralizing the tetanus toxin
CN108218984B (zh) * 2017-12-29 2018-10-26 珠海泰诺麦博生物技术有限公司 一种抗破伤风毒素的全人源中和抗体

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US4196265A (en) 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
FI64952C (fi) * 1977-06-15 1984-02-10 Wistar Inst Foerfarande foer framstaellning av genetiskt stabila cellinjer
US4172124A (en) 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
US4271145A (en) 1979-10-22 1981-06-02 The Massachusetts General Hospital Process for producing antibodies to hepatitis virus and cell lines therefor
WO1982001461A1 (en) * 1980-07-18 1982-05-13 Leland Stanford Junior Univ Human hybridomas,precursors and products
NZ198851A (en) 1980-11-07 1984-07-31 Wistar Inst Stable,continuous human myeloma cell line capable of hybridisation with antibody-producing cells:production of hybrid cell line
US4529694A (en) * 1982-04-16 1985-07-16 The Children's Medical Center Corporation Cell fusion
CA1240937A (en) * 1982-07-26 1988-08-23 Gordon R. Dreesman Monoclonal igm antibodies and method of preparation
WO1984004458A1 (en) * 1983-05-06 1984-11-22 Matthew Pollack Monoclonal antibodies reactive with endotoxin core

Also Published As

Publication number Publication date
ES530853A0 (es) 1986-02-01
ES530852A0 (es) 1984-11-16
EP0440266A2 (en) 1991-08-07
ES526097A0 (es) 1985-10-01
ES8600057A1 (es) 1985-10-01
CA1262238C (en) 1989-10-10
AU1969683A (en) 1984-04-05
EP0440266A3 (en) 1991-08-28
ATE70309T1 (de) 1991-12-15
DE3382474D1 (de) 1992-01-23
EP0105804A2 (en) 1984-04-18
DK450183A (da) 1984-03-31
AU567693B2 (en) 1987-12-03
EP0105804A3 (en) 1986-08-13
EP0105804B1 (en) 1991-12-11
IE832295L (en) 1984-03-30
DK450183D0 (da) 1983-09-29
IE60439B1 (en) 1994-07-13
CA1262238A (en) 1989-10-10
ES8604421A1 (es) 1986-02-01

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