ES8502440A1 - Procedimiento para preparar acepinoindoles. - Google Patents

Procedimiento para preparar acepinoindoles.

Info

Publication number
ES8502440A1
ES8502440A1 ES522008A ES522008A ES8502440A1 ES 8502440 A1 ES8502440 A1 ES 8502440A1 ES 522008 A ES522008 A ES 522008A ES 522008 A ES522008 A ES 522008A ES 8502440 A1 ES8502440 A1 ES 8502440A1
Authority
ES
Spain
Prior art keywords
compound
formula
procedure
alky
acepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522008A
Other languages
English (en)
Other versions
ES522008A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8502440A1 publication Critical patent/ES8502440A1/es
Publication of ES522008A0 publication Critical patent/ES522008A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR ACEPINOINDOLES.CONSISTE EN: A) TRATAR UN COMPUESTO DE FORMULA (II) CON UNA FUENTE DE ION HIDRUROS, PARA DAR UN COMPUESTO DE FORMULA (III); Y B) INTRODUCIR EL COMPUESTO DE FORMULA (III) O UNA SAL DE ADICION DEL MISMO, Y RECUPERAR EL COMPUESTO DE FORMULA (I) EN FORMA DE BASE LIBRE O EN FORMA DE SAL DE ADICION DE ACIDOS, DONDE R1 Y R2 SIGNIFICAN, INDEPENDIENTEMENTE ENTRE SI, HIDROGENO, HALOGENO CON UN NUMERO ATOMICO DE 9 A 35, ALQUILO DE C 1 A 4, ALCOXI DE C 1 A 4, ALQUILTIO DE C 1 A 4, O TRIFLUOROMETILO; R1 Y R2 SIGNIFICAN, INDEPENDIENTEMENTE ENTRE SI, H, HALOGENO CON NUMERO ATOMICO DE 9 A 35, ALQUILO DE C 1 A 4 O ALCOXI DE C 1 A 4; Y R3 REPRESENTA H, ALQUILO DE C 1 A 4, CICLOALQUILO DE C 3 A 6, CICLOALQUILALQUILO DE C 4 A 9, ALQUENILO DE C 3 A 5, ALQUINILO DE C 3 A 5.
ES522008A 1982-05-06 1983-05-02 Procedimiento para preparar acepinoindoles. Granted ES522008A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2806/82A CH649553A5 (de) 1982-05-06 1982-05-06 Azepinoindole und verfahren zu deren herstellung.

Publications (2)

Publication Number Publication Date
ES8502440A1 true ES8502440A1 (es) 1985-01-01
ES522008A0 ES522008A0 (es) 1985-01-01

Family

ID=4242007

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522008A Granted ES522008A0 (es) 1982-05-06 1983-05-02 Procedimiento para preparar acepinoindoles.

Country Status (17)

Country Link
JP (1) JPS58203993A (es)
AU (1) AU1425683A (es)
BE (1) BE896590A (es)
CH (1) CH649553A5 (es)
DE (1) DE3315467A1 (es)
DK (1) DK199883A (es)
ES (1) ES522008A0 (es)
FI (1) FI831475A7 (es)
FR (1) FR2526434A1 (es)
GB (1) GB2120662B (es)
HU (1) HU189275B (es)
IL (1) IL68576A0 (es)
IT (1) IT1197644B (es)
NL (1) NL8301552A (es)
PT (1) PT76632B (es)
SE (1) SE8302554L (es)
ZA (1) ZA833266B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193083B (en) * 1984-02-22 1987-08-28 Sandoz Ag Process for preparing diazepinoindole derivatives further pharmaceutical compositions containing such compounds
AU582564B2 (en) * 1985-02-20 1989-04-06 Sandoz Ltd. 2,3,4,5-tetrahydro-11-phenyl-1H-``1,4``diazepino``1,7-a`` indoles, their production and pharmaceutical compositions containing them
JP2004509894A (ja) * 2000-09-20 2004-04-02 ファルマシア・アンド・アップジョン・カンパニー 置換アゼピノ［４，５−ｂ］インドリン誘導体
WO2003014118A1 (en) * 2001-08-08 2003-02-20 Pharmacia & Upjohn Company THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES
EP1981337B1 (en) * 2006-01-19 2015-09-02 Athersys, Inc. Thiophenyl azepines as serotonin 5-ht2c receptor ligands and uses thereof
BRPI0907122B8 (pt) 2008-01-11 2021-05-25 Albany Molecular Res Inc compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8637501B2 (en) 2009-07-01 2014-01-28 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028381B1 (en) * 1979-11-02 1985-04-10 Sandoz Ag Azepinoindoles, process for their production and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
PT76632B (en) 1986-01-27
JPS58203993A (ja) 1983-11-28
FI831475L (fi) 1983-11-07
PT76632A (en) 1983-06-01
IL68576A0 (en) 1983-09-30
ZA833266B (en) 1984-12-24
CH649553A5 (de) 1985-05-31
GB2120662B (en) 1985-09-11
BE896590A (fr) 1983-10-28
GB2120662A (en) 1983-12-07
IT8348232A0 (it) 1983-05-06
DE3315467A1 (de) 1983-11-17
NL8301552A (nl) 1983-12-01
DK199883D0 (da) 1983-05-04
FI831475A0 (fi) 1983-04-29
FR2526434A1 (fr) 1983-11-10
ES522008A0 (es) 1985-01-01
HU189275B (en) 1986-06-30
IT1197644B (it) 1988-12-06
SE8302554D0 (sv) 1983-05-04
SE8302554L (sv) 1983-11-07
FI831475A7 (fi) 1983-11-07
GB8312159D0 (en) 1983-06-08
DK199883A (da) 1983-11-07
IT8348232A1 (it) 1984-11-06
AU1425683A (en) 1983-11-10

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