ES8503334A1 - Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) - Google Patents

Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)

Info

Publication number
ES8503334A1
ES8503334A1 ES523341A ES523341A ES8503334A1 ES 8503334 A1 ES8503334 A1 ES 8503334A1 ES 523341 A ES523341 A ES 523341A ES 523341 A ES523341 A ES 523341A ES 8503334 A1 ES8503334 A1 ES 8503334A1
Authority
ES
Spain
Prior art keywords
radical
aliphatic
together represent
hydrogen
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523341A
Other languages
English (en)
Other versions
ES523341A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8503334A1 publication Critical patent/ES8503334A1/es
Publication of ES523341A0 publication Critical patent/ES523341A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE QUINOLINONA, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN OXIDAR EL GRUPO R4 DEL COMPUESTO DE FORMULA GENERAL (II), MEDIANTE TRATAMIENTO CON UN COMPUESTO DE METAL PESADO OXIDANTE, A UN GRUPO CARBOXI. EL COMPUESTO ASI OBTENIDO SE PUEDE TRANSFORMAR EN OTRO COMPUESTO DE FORMULA (I) O EN UNA SAL.DE APLICACION EN LA PREPARACION DE COMPUESTOS FARMACOLOGICAMENTE ACTIVOS, ESPECIALMENTE COMO ANTIALERGICOS.
ES523341A 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) Granted ES523341A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH198681 1981-03-24

Publications (2)

Publication Number Publication Date
ES8503334A1 true ES8503334A1 (es) 1985-02-16
ES523341A0 ES523341A0 (es) 1985-02-16

Family

ID=4223231

Family Applications (7)

Application Number Title Priority Date Filing Date
ES510685A Expired ES8400092A1 (es) 1981-03-24 1982-03-23 Procedimiento para la obtencion de derivados de quinolinona.
ES523337A Granted ES523337A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona.
ES523341A Granted ES523341A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523338A Expired ES8503662A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no.510.685, presentada el 23 de marzo de 1.982).
ES523339A Expired ES8503663A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523342A Granted ES523342A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523340A Granted ES523340A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES510685A Expired ES8400092A1 (es) 1981-03-24 1982-03-23 Procedimiento para la obtencion de derivados de quinolinona.
ES523337A Granted ES523337A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona.

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES523338A Expired ES8503662A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no.510.685, presentada el 23 de marzo de 1.982).
ES523339A Expired ES8503663A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523342A Granted ES523342A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523340A Granted ES523340A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)

Country Status (22)

Country Link
US (1) US4476132A (es)
EP (1) EP0062001B1 (es)
JP (1) JPH066576B2 (es)
AR (4) AR242189A1 (es)
AT (1) ATE27451T1 (es)
AU (1) AU560003B2 (es)
CY (1) CY1412A (es)
DE (1) DE3276432D1 (es)
DK (1) DK159427C (es)
ES (7) ES8400092A1 (es)
FI (1) FI77853C (es)
GB (1) GB2095668B (es)
GR (1) GR78345B (es)
HK (1) HK3988A (es)
HU (1) HU192103B (es)
IE (1) IE53158B1 (es)
IL (1) IL65327A0 (es)
MY (1) MY8700806A (es)
NO (1) NO160074C (es)
NZ (1) NZ200106A (es)
PT (1) PT74634B (es)
ZA (1) ZA821957B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58219166A (ja) * 1982-06-14 1983-12-20 Nippon Shinyaku Co Ltd ４−キノロン誘導体
JPS58225065A (ja) * 1982-06-21 1983-12-27 Nippon Shinyaku Co Ltd ２−キノロン誘導体
US4675432A (en) * 1986-08-29 1987-06-23 American Cyanamid Company Method for the preparation of anilinofumarate
US6034100A (en) * 1993-03-10 2000-03-07 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting cytokine secretion
CN1703403A (zh) * 2000-10-02 2005-11-30 詹森药业有限公司 趋代谢的谷氨酸盐受体拮抗剂
NZ535438A (en) * 2002-03-29 2006-08-31 Janssen Pharmaceutica Nv Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands
WO2014062655A1 (en) 2012-10-16 2014-04-24 Janssen Pharmaceutica Nv HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt
MY189505A (en) 2012-10-16 2022-02-16 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of roryt
HK1213887A1 (zh) 2012-10-16 2016-07-15 Janssen Pharmaceutica N.V. RORγt的苯基连接的喹啉基调节剂
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
CA2927182A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Quinolinyl modulators of ror.gamma.t
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
CA2926339A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of roryt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB830832A (en) * 1957-02-15 1960-03-23 Ici Ltd New quinolones and therapeutic compositions containing them
GB1013224A (en) * 1962-06-21 1965-12-15 Ici Ltd Heterocyclic aminoethanols
CH519304A (de) * 1966-09-29 1972-02-29 Ciba Geigy Ag Verwendung von heterocyclischen Carbonsäureverbindungen zur Aufzucht von Geflügel
US3496184A (en) * 1969-03-18 1970-02-17 Ciba Geigy Corp Cyclopropylmethoxy-3-quinoline carboxylic acids and esters
NL7101049A (es) * 1970-01-28 1971-07-30
GB1334705A (en) * 1970-06-19 1973-10-24 Ici Ltd Pharmaceutical compositions containing kynurenic acid derivatives
CA942748A (en) * 1970-09-18 1974-02-26 Venkatachala L. Narayanan 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds
US4190659A (en) * 1973-08-27 1980-02-26 Sandoz, Inc. Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters
US4086349A (en) * 1975-07-30 1978-04-25 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinolopyran-4-one-2-carboxylic acid derivatives and salts thereof as novel compounds and as medicines for treatment of allergic asthma
JPS609511B2 (ja) * 1976-07-16 1985-03-11 大塚製薬株式会社 ５−カルボスチリルメタノ−ル誘導体
JPS609713B2 (ja) * 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
US4186201A (en) * 1977-02-07 1980-01-29 Riker Laboratories, Inc. Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds
US4187309A (en) * 1977-06-20 1980-02-05 Sandoz, Inc. 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4119720A (en) * 1977-07-06 1978-10-10 Sandoz, Inc. Unsaturated esters of 4-hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
DE2806879A1 (de) * 1978-02-17 1979-08-23 Sandoz Ag 4-hydroxy-2-chinolinon-3-carbonsaeure- esterderivate

Also Published As

Publication number Publication date
ATE27451T1 (de) 1987-06-15
MY8700806A (en) 1987-12-31
ES523339A0 (es) 1985-03-01
PT74634B (de) 1984-11-26
FI820983L (fi) 1982-09-25
EP0062001A2 (de) 1982-10-06
HU192103B (en) 1987-05-28
DK159427C (da) 1991-03-18
EP0062001B1 (de) 1987-05-27
DK130382A (da) 1982-09-25
AU8181982A (en) 1982-09-30
DE3276432D1 (en) 1987-07-02
NZ200106A (en) 1985-07-31
FI77853C (fi) 1989-05-10
ES8503663A1 (es) 1985-03-01
JPH066576B2 (ja) 1994-01-26
IE820670L (en) 1982-09-24
ES8503664A1 (es) 1985-03-01
ES523340A0 (es) 1985-03-01
CY1412A (en) 1988-04-22
ES510685A0 (es) 1983-10-16
ES523338A0 (es) 1985-03-01
NO160074C (no) 1989-03-08
AR240044A1 (es) 1990-01-31
JPS57192366A (en) 1982-11-26
FI77853B (fi) 1989-01-31
HK3988A (en) 1988-01-22
ES8503665A1 (es) 1985-03-01
ES8503662A1 (es) 1985-03-01
NO160074B (no) 1988-11-28
ES8503661A1 (es) 1985-03-01
IL65327A0 (en) 1982-05-31
GB2095668A (en) 1982-10-06
EP0062001A3 (en) 1983-01-26
PT74634A (de) 1982-04-01
IE53158B1 (en) 1988-08-03
ES8400092A1 (es) 1983-10-16
AR242376A1 (es) 1993-03-31
GB2095668B (en) 1985-04-11
ES523341A0 (es) 1985-02-16
NO820959L (no) 1982-09-27
AR242189A1 (es) 1993-03-31
AR240739A1 (es) 1990-10-31
ES523337A0 (es) 1985-03-01
DK159427B (da) 1990-10-15
ZA821957B (en) 1983-02-23
GR78345B (es) 1984-09-26
US4476132A (en) 1984-10-09
ES523342A0 (es) 1985-03-01
AU560003B2 (en) 1987-03-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303