ES8503664A1 - Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) - Google Patents
Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)Info
- Publication number
- ES8503664A1 ES8503664A1 ES523340A ES523340A ES8503664A1 ES 8503664 A1 ES8503664 A1 ES 8503664A1 ES 523340 A ES523340 A ES 523340A ES 523340 A ES523340 A ES 523340A ES 8503664 A1 ES8503664 A1 ES 8503664A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- aliphatic
- together represent
- hydrogen
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Acyl quinolinone derivatives Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KLYCPFXDDDMZNQ-UHFFFAOYSA-N Benzyne Chemical class C1=CC#CC=C1 KLYCPFXDDDMZNQ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE QUINOLINONA, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN TRANSFORMAR, EN UN COMPUESTO DE FORMULA (II), EL GRUPO CIANO MEDIANTE TRATAMIENTO CON AGUA O CON UN ALCOHOL, EN CADA CASO EN PRESENCIA DE UN ACIDO, EN UN GRUPO CARBOXI ESTERIFICADO O AMIDADO.DE APLICACION EN LA PREPARACION DE COMPUESTOS FARMACOLOGICAMENTE ACTIVOS, ESPECIALMENTE COMO ANTIALERGICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH198681 | 1981-03-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8503664A1 true ES8503664A1 (es) | 1985-03-01 |
| ES523340A0 ES523340A0 (es) | 1985-03-01 |
Family
ID=4223231
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES510685A Granted ES510685A0 (es) | 1981-03-24 | 1982-03-23 | Procedimiento para la obtencion de derivados de quinolinona. |
| ES523342A Expired ES8503665A1 (es) | 1981-03-24 | 1983-06-16 | Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) |
| ES523341A Granted ES523341A0 (es) | 1981-03-24 | 1983-06-16 | Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) |
| ES523337A Granted ES523337A0 (es) | 1981-03-24 | 1983-06-16 | Procedimiento para la obtencion de derivados de quinolinona. |
| ES523339A Granted ES523339A0 (es) | 1981-03-24 | 1983-06-16 | Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) |
| ES523340A Granted ES523340A0 (es) | 1981-03-24 | 1983-06-16 | Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) |
| ES523338A Expired ES8503662A1 (es) | 1981-03-24 | 1983-06-16 | Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no.510.685, presentada el 23 de marzo de 1.982). |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES510685A Granted ES510685A0 (es) | 1981-03-24 | 1982-03-23 | Procedimiento para la obtencion de derivados de quinolinona. |
| ES523342A Expired ES8503665A1 (es) | 1981-03-24 | 1983-06-16 | Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) |
| ES523341A Granted ES523341A0 (es) | 1981-03-24 | 1983-06-16 | Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) |
| ES523337A Granted ES523337A0 (es) | 1981-03-24 | 1983-06-16 | Procedimiento para la obtencion de derivados de quinolinona. |
| ES523339A Granted ES523339A0 (es) | 1981-03-24 | 1983-06-16 | Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES523338A Expired ES8503662A1 (es) | 1981-03-24 | 1983-06-16 | Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no.510.685, presentada el 23 de marzo de 1.982). |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4476132A (es) |
| EP (1) | EP0062001B1 (es) |
| JP (1) | JPH066576B2 (es) |
| AR (4) | AR242189A1 (es) |
| AT (1) | ATE27451T1 (es) |
| AU (1) | AU560003B2 (es) |
| CY (1) | CY1412A (es) |
| DE (1) | DE3276432D1 (es) |
| DK (1) | DK159427C (es) |
| ES (7) | ES510685A0 (es) |
| FI (1) | FI77853C (es) |
| GB (1) | GB2095668B (es) |
| GR (1) | GR78345B (es) |
| HK (1) | HK3988A (es) |
| HU (1) | HU192103B (es) |
| IE (1) | IE53158B1 (es) |
| IL (1) | IL65327A0 (es) |
| MY (1) | MY8700806A (es) |
| NO (1) | NO160074C (es) |
| NZ (1) | NZ200106A (es) |
| PT (1) | PT74634B (es) |
| ZA (1) | ZA821957B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58219166A (ja) * | 1982-06-14 | 1983-12-20 | Nippon Shinyaku Co Ltd | ４−キノロン誘導体 |
| JPS58225065A (ja) * | 1982-06-21 | 1983-12-27 | Nippon Shinyaku Co Ltd | ２−キノロン誘導体 |
| US4675432A (en) * | 1986-08-29 | 1987-06-23 | American Cyanamid Company | Method for the preparation of anilinofumarate |
| US6034100A (en) * | 1993-03-10 | 2000-03-07 | Otsuka Pharmaceutical Co., Ltd. | Method for inhibiting cytokine secretion |
| CN1703403A (zh) * | 2000-10-02 | 2005-11-30 | 詹森药业有限公司 | 趋代谢的谷氨酸盐受体拮抗剂 |
| CN1642580B (zh) * | 2002-03-29 | 2010-05-26 | 詹森药业有限公司 | 放射性标记的喹啉和喹啉酮衍生物及其作为代谢性谷氨酸受体配体的制造用途 |
| ES2619610T3 (es) | 2012-10-16 | 2017-06-26 | Janssen Pharmaceutica Nv | Moduladores de ROR-gamma-t de quinolinilo enlazado con heteroarilo |
| MY189505A (en) | 2012-10-16 | 2022-02-16 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of roryt |
| CA2888485C (en) | 2012-10-16 | 2021-01-26 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of ror.gamma.t |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| BR112016008215A2 (pt) | 2013-10-15 | 2017-09-26 | Janssen Pharmaceutica Nv | moduladores de quinolinila ligados por alquila de roryt |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| ES2742843T3 (es) | 2013-10-15 | 2020-02-17 | Janssen Pharmaceutica Nv | Moduladores de quinolinilo de ROR(gamma)t |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB830832A (en) * | 1957-02-15 | 1960-03-23 | Ici Ltd | New quinolones and therapeutic compositions containing them |
| GB1013224A (en) * | 1962-06-21 | 1965-12-15 | Ici Ltd | Heterocyclic aminoethanols |
| CH538476A (de) * | 1966-09-29 | 1973-06-30 | Ciba Geigy Ag | Verfahren zur Herstellung von heterocyclischen Carbonsäuren |
| US3496184A (en) * | 1969-03-18 | 1970-02-17 | Ciba Geigy Corp | Cyclopropylmethoxy-3-quinoline carboxylic acids and esters |
| CA947301A (en) * | 1970-01-28 | 1974-05-14 | Sumitomo Chemical Company | Process for the preparation of compound having antibacterial action |
| GB1334705A (en) * | 1970-06-19 | 1973-10-24 | Ici Ltd | Pharmaceutical compositions containing kynurenic acid derivatives |
| CA942748A (en) * | 1970-09-18 | 1974-02-26 | Venkatachala L. Narayanan | 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds |
| US4190659A (en) * | 1973-08-27 | 1980-02-26 | Sandoz, Inc. | Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters |
| US4086349A (en) * | 1975-07-30 | 1978-04-25 | Mitsubishi Yuka Pharmaceutical Co., Ltd. | Quinolopyran-4-one-2-carboxylic acid derivatives and salts thereof as novel compounds and as medicines for treatment of allergic asthma |
| JPS609511B2 (ja) * | 1976-07-16 | 1985-03-11 | 大塚製薬株式会社 | ５−カルボスチリルメタノ−ル誘導体 |
| JPS609713B2 (ja) * | 1976-10-08 | 1985-03-12 | 大塚製薬株式会社 | カルボスチリル誘導体 |
| US4186201A (en) * | 1977-02-07 | 1980-01-29 | Riker Laboratories, Inc. | Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds |
| US4187309A (en) * | 1977-06-20 | 1980-02-05 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
| US4119720A (en) * | 1977-07-06 | 1978-10-10 | Sandoz, Inc. | Unsaturated esters of 4-hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
| DE2806879A1 (de) * | 1978-02-17 | 1979-08-23 | Sandoz Ag | 4-hydroxy-2-chinolinon-3-carbonsaeure- esterderivate |
-
1982
- 1982-03-18 DE DE8282810126T patent/DE3276432D1/de not_active Expired
- 1982-03-18 AT AT82810126T patent/ATE27451T1/de not_active IP Right Cessation
- 1982-03-18 EP EP82810126A patent/EP0062001B1/de not_active Expired
- 1982-03-19 US US06/360,016 patent/US4476132A/en not_active Expired - Lifetime
- 1982-03-22 GR GR67672A patent/GR78345B/el unknown
- 1982-03-22 PT PT74634A patent/PT74634B/pt not_active IP Right Cessation
- 1982-03-22 FI FI820983A patent/FI77853C/fi not_active IP Right Cessation
- 1982-03-23 GB GB8208394A patent/GB2095668B/en not_active Expired
- 1982-03-23 NO NO820959A patent/NO160074C/no unknown
- 1982-03-23 AU AU81819/82A patent/AU560003B2/en not_active Ceased
- 1982-03-23 IE IE670/82A patent/IE53158B1/en not_active IP Right Cessation
- 1982-03-23 DK DK130382A patent/DK159427C/da not_active IP Right Cessation
- 1982-03-23 HU HU82881A patent/HU192103B/hu not_active IP Right Cessation
- 1982-03-23 NZ NZ200106A patent/NZ200106A/en unknown
- 1982-03-23 IL IL65327A patent/IL65327A0/xx not_active IP Right Cessation
- 1982-03-23 ES ES510685A patent/ES510685A0/es active Granted
- 1982-03-23 CY CY141282A patent/CY1412A/en unknown
- 1982-03-23 ZA ZA821957A patent/ZA821957B/xx unknown
- 1982-03-24 AR AR82288857A patent/AR242189A1/es active
- 1982-03-24 JP JP57045754A patent/JPH066576B2/ja not_active Expired - Lifetime
-
1983
- 1983-06-16 ES ES523342A patent/ES8503665A1/es not_active Expired
- 1983-06-16 ES ES523341A patent/ES523341A0/es active Granted
- 1983-06-16 ES ES523337A patent/ES523337A0/es active Granted
- 1983-06-16 ES ES523339A patent/ES523339A0/es active Granted
- 1983-06-16 ES ES523340A patent/ES523340A0/es active Granted
- 1983-06-16 ES ES523338A patent/ES8503662A1/es not_active Expired
- 1983-11-30 AR AR29497383A patent/AR240739A1/es active
- 1983-11-30 AR AR83294975A patent/AR242376A1/es active
- 1983-11-30 AR AR294972A patent/AR240044A1/es active
-
1987
- 1987-12-30 MY MY806/87A patent/MY8700806A/xx unknown
-
1988
- 1988-01-14 HK HK39/88A patent/HK3988A/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8503661A1 (es) | Procedimiento para la obtencion de derivados de quinolinona. | |
| IL63613A (en) | Dihydrohalo oxo-pyrido(1,2,3-de)(1,4)benzoxazine carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them | |
| ES8305356A1 (es) | Un procedimiento para la produccion de un derivado de carbostirilo | |
| ES8308877A1 (es) | Procedimiento para la obtencion de derivados del acido 2-(3'-hidroxi-pirid-2'-il)-2-tiazolin-4-carboxilico. | |
| ES8702371A1 (es) | Un procedimiento para preparar nuevos derivados de 6-(4-fenilo sustituido -3(2h) piradazinona. | |
| ES2000368A6 (es) | Un procedimiento para preparar di-t-butilfenoles sustituidos | |
| ES8403910A1 (es) | Procedimiento para la preparacion de nitratos de amino-deso-xi-1.4;3.6-dianhidro-hexito,asi como de sus sales de adicionacida farmacologicamente inocuas | |
| IL75273A (en) | Cephalosporin derivatives,process for their preparation and pharmaceutical compositions containing them | |
| ES8801280A1 (es) | Procedimiento para la obtencion de benzo-(pirano y tiopirano)-piridinas | |
| HUT48622A (en) | Process for producing hydrogenated 1-(benzoxacycloalkyl)-pyridinecarboxylic acid derivatives and pharmaceutical compositions comprising such compounds | |
| ATE21101T1 (de) | N-iminopyridinium-betain-derivate, ihre herstellung und ihre verwendung als arzneimittel. | |
| ES8106706A1 (es) | Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos. | |
| ES8403911A1 (es) | Procedimiento de preparacion de mononitratos de 1.4,3.6- dianhidro-hexito sustituidos en 2-0 y 5-0 | |
| ES8300776A1 (es) | Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina | |
| DE3269533D1 (en) | New quinolylacetic acid compounds and pharmaceutical compositions containing them | |
| ES472208A1 (es) | Procedimiento para la obtencion de nuevos derivados de 2- bencimidazol. | |
| JPS5576872A (en) | Imidazolidinone derivative | |
| ES8106521A1 (es) | Procedimiento para la obtencion de nuevos derivados de 4,7- fenantrolina | |
| IL67168A0 (en) | 1-furyl-3,4-dihydroisoquinolines,their preparation and pharmaceutical compositions containing them | |
| DE3162691D1 (en) | 4h-benzo(4,5)cyclohepta(1,2-b)furan derivatives, process for their preparation and their use as medicines | |
| ES476076A1 (es) | Un procedimiento para preparar derivados de 1,3-tiazol. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |