ES8505251A3 - Procedimiento para la obtencion del clorhidrato de 8-4-4-(2-pirimidinil)-1-piperazinil-butil-8-azaspiro 4,5-decano-7,9- diona. - Google Patents

Procedimiento para la obtencion del clorhidrato de 8-4-4-(2-pirimidinil)-1-piperazinil-butil-8-azaspiro 4,5-decano-7,9- diona.

Info

Publication number
ES8505251A3
ES8505251A3 ES84530335A ES530335A ES8505251A3 ES 8505251 A3 ES8505251 A3 ES 8505251A3 ES 84530335 A ES84530335 A ES 84530335A ES 530335 A ES530335 A ES 530335A ES 8505251 A3 ES8505251 A3 ES 8505251A3
Authority
ES
Spain
Prior art keywords
diona
azaspiro
decane
butyl
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES84530335A
Other languages
English (en)
Other versions
ES530335A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inke SA
Original Assignee
Inke SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inke SA filed Critical Inke SA
Publication of ES8505251A3 publication Critical patent/ES8505251A3/es
Publication of ES530335A0 publication Critical patent/ES530335A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE CLORHIDRATO DE 8-4-4-(2-PIRIMIDINIL)-1-PIPERAZINIL)-1-PIPERAZINILBUTIL-8-AZSPIRO 4,5 DECANO-7,9-DIONA.COMPRENDE: A) HACER REACCIONAR LA 1-(2-PIRIMIDINIL) PIPERAZINA CON LA 8-(4-CLORO-BUTIL)-8-AZASPIRO 4,5 DECANO-7,9-DIONA, EN PRESENCIA DE CARBONATO SODICO O POTASICO, EN UN DISOLVENTE COMO METANOL, ISOPROPANOL Y OTROS Y A UNA TEMPERATURA ENTRE 70J Y 120JC, PARA OBTENER LA 8-4-4-(2-PIRIMIDIL)-1-PIPERAZIMILBUTIL-8-AZASPIRO 4,5 DECANO-7,9-DIONA Y B) TRATAR A LA 8-4-4-(2-PIRIMIDINIL)-1-PIPERAZINILBUTIL-8-AZASPIRO 4,5 DECANO-7,9-DIONA CON CLH, EN UN DISOLVENTE COMO METANOL, ETANOL Y OTROS, PARA OBTENER EL CLORHIDRATO DE 8-4-4-(2-PIRIMIDINIL)-1-PIPERAZINILBUTIL-8-AZASPIRO 4,5 DECANO-7,9-DIONA.
ES530335A 1969-11-24 1984-03-07 Procedimiento para la obtencion del clorhidrato de 8-4-4-(2-pirimidinil)-1-piperazinil-butil-8-azaspiro 4,5-decano-7,9- diona. Granted ES530335A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00879604A US3717634A (en) 1969-11-24 1969-11-24 N-(heteroarcyclic)piperazinylalkyl-azaspiroalkanediones

Publications (2)

Publication Number Publication Date
ES8505251A3 true ES8505251A3 (es) 1985-05-16
ES530335A0 ES530335A0 (es) 1985-05-16

Family

ID=25374483

Family Applications (1)

Application Number Title Priority Date Filing Date
ES530335A Granted ES530335A0 (es) 1969-11-24 1984-03-07 Procedimiento para la obtencion del clorhidrato de 8-4-4-(2-pirimidinil)-1-piperazinil-butil-8-azaspiro 4,5-decano-7,9- diona.

Country Status (14)

Country Link
US (2) US3717634A (es)
BE (1) BE759371A (es)
CH (2) CH552607A (es)
CY (1) CY886A (es)
DE (1) DE2057845A1 (es)
DK (1) DK141753B (es)
ES (1) ES530335A0 (es)
FR (1) FR2073406B1 (es)
GB (1) GB1332194A (es)
HK (1) HK6177A (es)
KE (1) KE2691A (es)
MY (1) MY7700151A (es)
NL (1) NL7017031A (es)
ZA (1) ZA707826B (es)

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DK141753C (es) 1980-11-24
BE759371A (fr) 1971-05-24
MY7700151A (en) 1977-12-31
HK6177A (en) 1977-02-04
FR2073406B1 (es) 1974-10-11
CH552607A (de) 1974-08-15
CY886A (en) 1977-03-18
US3717634A (en) 1973-02-20
DE2057845A1 (de) 1971-06-09
ZA707826B (en) 1971-07-28
KE2691A (en) 1977-03-04
CH552608A (de) 1974-08-15
DK141753B (da) 1980-06-09
ES530335A0 (es) 1985-05-16
FR2073406A1 (es) 1971-10-01
NL7017031A (es) 1971-05-26
US3907801A (en) 1975-09-23
GB1332194A (en) 1973-10-03

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