ES8506308A1 - Un procedimiento para producir una nueva bleomicina substituida en (amido)-n - Google Patents
Un procedimiento para producir una nueva bleomicina substituida en (amido)-nInfo
- Publication number
- ES8506308A1 ES8506308A1 ES532369A ES532369A ES8506308A1 ES 8506308 A1 ES8506308 A1 ES 8506308A1 ES 532369 A ES532369 A ES 532369A ES 532369 A ES532369 A ES 532369A ES 8506308 A1 ES8506308 A1 ES 8506308A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- formula
- preparation
- bleomycin
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010006654 Bleomycin Proteins 0.000 title abstract 3
- 229960001561 bleomycin Drugs 0.000 title abstract 3
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical class N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 cyano, benzyloxy Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 230000002829 reductive effect Effects 0.000 abstract 2
- 206010061924 Pulmonary toxicity Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006482 condensation reaction Methods 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 231100000374 pneumotoxicity Toxicity 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C21—METALLURGY OF IRON
- C21B—MANUFACTURE OF IRON OR STEEL
- C21B2100/00—Handling of exhaust gases produced during the manufacture of iron or steel
- C21B2100/40—Gas purification of exhaust gases to be recirculated or used in other metallurgical processes
- C21B2100/44—Removing particles, e.g. by scrubbing, dedusting
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/20—Recycling
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE BLEOMICINAS (AMIDO) N-SUSTITUIDAS, DE FORMULA (I) EN LA QUE BM ES UN RESIDUO DE LA CADENA PRINCIPAL DE BLEOMICINA; X ES ALQUILO; Y R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE CONDENSACION DE MODO REDUCTOR DE UN DERIVADO (AMIDO) N-SUSTITUIDO DE 3-N-METIL-N-(3-AMINOPROPIL) AMINO PROPILAMINOBLEOMICINA, DE FORMULA (II), EN LA QUE BM Y X TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN ALDEHIDO DE FORMULA R1CHO, EN LA QUE R1 ES EL MISMO QUE EN LA FORMULA (I).ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE VARIOS TIPOS DE CANCER.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58084605A JPS59210100A (ja) | 1983-05-14 | 1983-05-14 | 新規アミドｎ置換ブレオマイシン類の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8506308A1 true ES8506308A1 (es) | 1985-07-01 |
| ES532369A0 ES532369A0 (es) | 1985-07-01 |
Family
ID=13835313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532369A Granted ES532369A0 (es) | 1983-05-14 | 1984-05-10 | Un procedimiento para producir una nueva bleomicina substituida en (amido)-n |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS59210100A (es) |
| KR (1) | KR910001725B1 (es) |
| AT (1) | AT380886B (es) |
| CA (1) | CA1276400C (es) |
| CS (1) | CS241086B2 (es) |
| DK (1) | DK237184A (es) |
| ES (1) | ES532369A0 (es) |
| HU (1) | HU189110B (es) |
| YU (1) | YU43845B (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58116496A (ja) * | 1981-12-29 | 1983-07-11 | Nippon Kayaku Co Ltd | アミドｎ置換ブレオマイシン類 |
| JPS636078A (ja) * | 1986-06-27 | 1988-01-12 | Nippon Zeon Co Ltd | 半導体用薬剤の収納容器部材 |
-
1983
- 1983-05-14 JP JP58084605A patent/JPS59210100A/ja active Granted
-
1984
- 1984-05-08 CA CA000453841A patent/CA1276400C/en not_active Expired - Lifetime
- 1984-05-10 ES ES532369A patent/ES532369A0/es active Granted
- 1984-05-10 CS CS843468A patent/CS241086B2/cs unknown
- 1984-05-11 HU HU841839A patent/HU189110B/hu not_active IP Right Cessation
- 1984-05-11 DK DK237184A patent/DK237184A/da not_active Application Discontinuation
- 1984-05-12 KR KR1019840002574A patent/KR910001725B1/ko not_active Expired
- 1984-05-14 YU YU837/84A patent/YU43845B/xx unknown
- 1984-05-14 AT AT0157084A patent/AT380886B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| YU83784A (en) | 1987-02-28 |
| JPS59210100A (ja) | 1984-11-28 |
| CS241086B2 (en) | 1986-03-13 |
| KR910001725B1 (ko) | 1991-03-22 |
| HU189110B (en) | 1986-06-30 |
| HUT34223A (en) | 1985-02-28 |
| CS346884A2 (en) | 1985-06-13 |
| DK237184D0 (da) | 1984-05-11 |
| DK237184A (da) | 1984-11-15 |
| CA1276400C (en) | 1990-11-13 |
| YU43845B (en) | 1989-12-31 |
| AT380886B (de) | 1986-07-25 |
| ES532369A0 (es) | 1985-07-01 |
| ATA157084A (de) | 1985-12-15 |
| KR840009304A (ko) | 1984-12-26 |
| JPH03879B2 (es) | 1991-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960506 |