ES8507110A1 - Procedimiento para la preparacion de derivados del acido indolacetico - Google Patents

Procedimiento para la preparacion de derivados del acido indolacetico

Info

Publication number
ES8507110A1
ES8507110A1 ES538029A ES538029A ES8507110A1 ES 8507110 A1 ES8507110 A1 ES 8507110A1 ES 538029 A ES538029 A ES 538029A ES 538029 A ES538029 A ES 538029A ES 8507110 A1 ES8507110 A1 ES 8507110A1
Authority
ES
Spain
Prior art keywords
acid derivatives
inolacetic
procedure
preparation
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538029A
Other languages
English (en)
Other versions
ES538029A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
GC Biopharma Corp
Original Assignee
Green Cross Corp Japan
Green Cross Corp Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan, Green Cross Corp Korea filed Critical Green Cross Corp Japan
Publication of ES538029A0 publication Critical patent/ES538029A0/es
Publication of ES8507110A1 publication Critical patent/ES8507110A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DEL ACIDO INDOL-ACETICO DE FORMULA (I) EN LA QUE R1 ES HALOGENO; R2 HALOGENO O ALQUILO INFERIOR; X ES -C-O- O -O-C-; R3 ES ALQUILO CON 1 A 15 ATOMOS DE CARBONO O ALQUENILO CON 2 A 15 ATOMOS DE CARBONO; Y N ES 1, 2 O 3.MEDIANTE REACCION DEL COMPUESTO DE FORMULA (II) CON OTRO DE ESTER DE FORMULA (III) O (IV) DONDE R1, R2, R3 Y N SON LOS INDICADOS E Y ES UN ATOMO DE HALOGENO. SE EMPLEA ENTRE 1 Y 10 ML/MMOL DE CLORURO DE METILENO O CLOROFORMO COMO DISOLVENTE; UNA SAL CUATERNARIA DE AMONIO COMO CATILIZADOR; A TEMPERATURA ENTRE 0JC Y 25JC, DURANTE 2 A 4 HORAS.DE APLICACION COMO ANALGESICOS O ANTIFLOGISTICOS SIN EFECTOS SECUNDARIOS SOBRE EL TRACTO INTESTINAL.
ES538029A 1983-11-18 1984-11-16 Procedimiento para la preparacion de derivados del acido indolacetico Expired ES8507110A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58218431A JPS60112760A (ja) 1983-11-18 1983-11-18 インド−ル酢酸誘導体及びその脂肪乳剤

Publications (2)

Publication Number Publication Date
ES538029A0 ES538029A0 (es) 1985-09-01
ES8507110A1 true ES8507110A1 (es) 1985-09-01

Family

ID=16719797

Family Applications (1)

Application Number Title Priority Date Filing Date
ES538029A Expired ES8507110A1 (es) 1983-11-18 1984-11-16 Procedimiento para la preparacion de derivados del acido indolacetico

Country Status (4)

Country Link
EP (1) EP0144845B1 (es)
JP (1) JPS60112760A (es)
DE (2) DE3469737D1 (es)
ES (1) ES8507110A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3443993A1 (de) * 1984-12-01 1986-06-05 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von neuen indolderivaten und deren verwendung
US5939455A (en) * 1997-03-11 1999-08-17 Beacon Laboratories, Inc. Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives
US6110955A (en) * 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Metabolically stabilized oxyalkylene esters and uses thereof
US6762182B1 (en) 1999-01-07 2004-07-13 Vanderbilt University Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
US6207700B1 (en) 1999-01-07 2001-03-27 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use
US6306890B1 (en) 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
CA2562783A1 (en) 2004-04-26 2005-12-01 Vanderbilt University Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
WO2007149456A2 (en) 2006-06-19 2007-12-27 Vanderbilt University Methods and compositions for diagnostic and therapeutic targeting of cox-2
WO2013059245A1 (en) 2011-10-17 2013-04-25 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2234651C3 (de) * 1972-07-14 1978-11-09 Troponwerke Gmbh & Co Kg, 5000 Koeln Eckige Klammer auf l-(p-Chlorbenzoyl)-5-methoxy-2-methyl-3-indol] -acetoxj essigsaure, ihre Salze mit Basen, Verfahren zu ihrer Herstellung sowie pharmakologische Zubereitungen
DE2257867C2 (de) * 1972-11-25 1982-09-23 Troponwerke GmbH & Co KG, 5000 Köln Verfahren zur Herstellung von 1-Benzoylindol-Derivaten

Also Published As

Publication number Publication date
EP0144845B1 (en) 1988-03-09
EP0144845A1 (en) 1985-06-19
ES538029A0 (es) 1985-09-01
DE144845T1 (de) 1986-05-22
DE3469737D1 (en) 1988-04-14
JPS60112760A (ja) 1985-06-19

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