ES8507155A3 - Steroid(s) of prednisolone series - Google Patents
Steroid(s) of prednisolone seriesInfo
- Publication number
- ES8507155A3 ES8507155A3 ES538539A ES538539A ES8507155A3 ES 8507155 A3 ES8507155 A3 ES 8507155A3 ES 538539 A ES538539 A ES 538539A ES 538539 A ES538539 A ES 538539A ES 8507155 A3 ES8507155 A3 ES 8507155A3
- Authority
- ES
- Spain
- Prior art keywords
- steroid
- 17alpha
- formula
- prednisolone
- series
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 title abstract 3
- 150000003117 prednisolones Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 238000005886 esterification reaction Methods 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 238000006136 alcoholysis reaction Methods 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
Abstract
Steroids of formula (I), in which Y is hydrogen or halogen and Z is hydrogen, halogen or lower alkyl, are made by (a) ortho-esterification of a steroid of formula (II) to form a cpd. of formula (III), in which R and R' are 1-6C alkyl; (b) hydrolysis to a 17alpha-ester; (c) esterification to a 12alpha, 21-diester in which the new acyl gp. is 2-7C; (d) elimination of the 17alpha-acyloxy gp.; (e) selective oxidn. of the Delta16-21 ester formed; and (f) hydrolysis or alcoholysis of the 16alpha, 17alpha-dihydroxy 21-ester obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES538539A ES8507155A3 (en) | 1984-12-12 | 1984-12-12 | Steroid(s) of prednisolone series |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES538539A ES8507155A3 (en) | 1984-12-12 | 1984-12-12 | Steroid(s) of prednisolone series |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES538539A0 ES538539A0 (en) | 1985-09-01 |
| ES8507155A3 true ES8507155A3 (en) | 1985-09-01 |
Family
ID=8488307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES538539A Expired ES8507155A3 (en) | 1984-12-12 | 1984-12-12 | Steroid(s) of prednisolone series |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES8507155A3 (en) |
-
1984
- 1984-12-12 ES ES538539A patent/ES8507155A3/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES538539A0 (en) | 1985-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS54128560A (en) | Hydrocortisone derivative | |
| JPS5519280A (en) | Method of obtaining pure 22*perfluoroalkyl** ethanol from mixture of said ethanol* 22*perfluoroalkyl**ethylene and in cases 22*perfluoroalkyl**ethyl ester | |
| KR890700130A (en) | Method for Steroidal 17α-silyl ether and corticosteroids and progesterone | |
| DE3674121D1 (en) | HYDROCORTISON'S MOST CONTAINING O / W CREAM. | |
| PT72989B (en) | Process for the preparation of a mixture of an anti-inflammatory steroid and a fluor-chloro-hydrocarbon to be used as a propellant | |
| DE3172829D1 (en) | Process for the production of fuel compositions and fuel compositions thereby produced | |
| HUT34513A (en) | Process for production of 1-alkil-androsta-1,4-dien-3,17-dions and medical preparates consisting of such compounds | |
| DE3267355D1 (en) | Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids | |
| IL49103A (en) | 16 17 -and 21-retioates of steroids of the pregnane series | |
| GB2037290B (en) | Preparation of 21-acylthio steroids of the pregn-4-ene and pregna-1,4-diene series | |
| IL56495A0 (en) | Steroids of the pregnane series substituted in the 17-position and the jpreparation and use thereof | |
| PL267370A1 (en) | The method of alcohol izoprophyl manufacture and of c-3 alcohols with 4 to 5 carbon atoms | |
| IL56494A0 (en) | New 11-hydroxy-steroids of the pregnane series substitutedin the 17-position and their production and use | |
| PT78504A (en) | New process for the preparation of 21-hydroxy-20-keto-delta 16-steroids and new intermediate compounds formed in this process | |
| YU176780A (en) | Process for obtaining steroids of the pregnane structure | |
| YU26779A (en) | Process for preparing anti-inflammatory steroids the androstane series | |
| DE3360856D1 (en) | Pregnane derivatives and method of producing the same | |
| EP0034365A3 (en) | Process for the preparation of 3,20-dioxo-pregn-4-ene and/or 3,20-dioxo-pregna-1,4-diene | |
| JPS54163536A (en) | Thioketal producing method | |
| JPS5788199A (en) | Synthetic intermediate of corticoids | |
| ES8603719A3 (en) | Steroid(s) of prednisolone series | |
| JPS54130548A (en) | Prednisolone derivative | |
| JPS54157563A (en) | Stereospecific or stereoselective manufacture of imidazolylloxime ether derivative and imidazolylloxime derivative and imidazolylloxime ether derivative made thereby | |
| JPS5788200A (en) | Synthetic intermediate of corticoids | |
| IT7850629A0 (en) | PROCEDURE FOR THE PRODUCTION OF 3/20-DIOX 9ALFA-FLUORINE 11BETAHYDROXY 16ALFA-METHYL 21-ACETOXY PREGNA-1/4-DIENE |