ES8507531A1 - Un procedimiento para preparar espiro (benzofuran-2(3h), 1'cicloalcanos) sustituidos en posicion 2' - Google Patents
Un procedimiento para preparar espiro (benzofuran-2(3h), 1'cicloalcanos) sustituidos en posicion 2'Info
- Publication number
- ES8507531A1 ES8507531A1 ES529361A ES529361A ES8507531A1 ES 8507531 A1 ES8507531 A1 ES 8507531A1 ES 529361 A ES529361 A ES 529361A ES 529361 A ES529361 A ES 529361A ES 8507531 A1 ES8507531 A1 ES 8507531A1
- Authority
- ES
- Spain
- Prior art keywords
- medicaments
- compounds
- substituted
- cycloalkanes
- benzofuran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- -1 amino, hydroxy Chemical class 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE ESPIRO-BENZOFURAN-2(3H),1-CICLOALCANOS SUSTITUIDOS EN POSICION 2, QUE CORRESPONDEN A LA FORMULA ESTRUCTURAL (I), EN LA QUE X ES AMINO SUSTITUIDO CON ALCOHILO INFERIOR O NITRO; M ES 1, 2 O 3; N ES 0, 1 O 2; P ES 0, 1 O 2; Y R1 Y R2 SON CADA UNO DE ELLOS HIDROGENO O ALCOHILO INFERIOR, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES.COMPRNDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE NITRA UN COMPUESTO DE FORMULA (I), EN LA QUE X ES HIDROGENO, PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE X ES -NO2; SEGUNDA, SE REDUCE EL COMPUESTO DE FORMULA (I) OBTENIDO ANTERIORMENTE PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE X ES -NH2; Y POR ULTIMO, OPCIONALMENTE SE HIDROGENA UN COMPUESTO DE FORMULA (I), EN LA QUE X ES -NO2, JUNTO CON FORMALDEHIDO Y EN PRESENCIA DE UN CATALIZADOR DE PALADIO, PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE X ES -N(CH3)2.DE APLICACION EN EL TRATAMIENTO DE LA DEPRESION EN LOS MAMIFEROS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/313,097 US4404221A (en) | 1981-10-19 | 1981-10-19 | 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use |
| US06/416,446 US4517311A (en) | 1981-10-19 | 1982-09-13 | 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES529361A0 ES529361A0 (es) | 1985-09-01 |
| ES8507531A1 true ES8507531A1 (es) | 1985-09-01 |
Family
ID=26978681
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES516610A Granted ES516610A0 (es) | 1981-10-19 | 1982-10-18 | "un procedimiento para preparar espiro benzofuran-2(3h), 1- cicloalcanos sustituidos en posicion 2". |
| ES529362A Granted ES529362A0 (es) | 1981-10-19 | 1984-02-01 | Un procedimiento para preparar espiro (benzofuran-2(3h), 1'-cicloalcanos) sustituidos en posicion 2' |
| ES529361A Expired ES8507531A1 (es) | 1981-10-19 | 1984-02-01 | Un procedimiento para preparar espiro (benzofuran-2(3h), 1'cicloalcanos) sustituidos en posicion 2' |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES516610A Granted ES516610A0 (es) | 1981-10-19 | 1982-10-18 | "un procedimiento para preparar espiro benzofuran-2(3h), 1- cicloalcanos sustituidos en posicion 2". |
| ES529362A Granted ES529362A0 (es) | 1981-10-19 | 1984-02-01 | Un procedimiento para preparar espiro (benzofuran-2(3h), 1'-cicloalcanos) sustituidos en posicion 2' |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4517311A (es) |
| EP (1) | EP0077536B1 (es) |
| KR (1) | KR880001814B1 (es) |
| AU (1) | AU564232B2 (es) |
| DE (1) | DE3272035D1 (es) |
| ES (3) | ES516610A0 (es) |
| IL (1) | IL67011A (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4910323A (en) * | 1981-10-19 | 1990-03-20 | Hoechst Roussel Pharmaceuticals, Inc. | 2'-substituted-spiro(benzofuran-2(3H),1'-cyclohexanes) and intermediates thereof |
| US4623657A (en) | 1985-09-05 | 1986-11-18 | Hoechst-Roussel Pharmaceuticals Inc. | Spiro [benzofuran-2(3H),1'-cycloheptane]s and their therapeutic use |
| US5506247A (en) * | 1988-04-15 | 1996-04-09 | T Cell Sciences, Inc. | Compounds that inhibit complement and/or suppress immune activity |
| US5173499A (en) * | 1988-04-15 | 1992-12-22 | T Cell Sciences, Inc. | Compounds which inhibit complement and/or suppress immune activity |
| US5366986A (en) * | 1988-04-15 | 1994-11-22 | T Cell Sciences, Inc. | Compounds which inhibit complement and/or suppress immune activity |
| US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB913535A (en) * | 1960-05-16 | 1962-12-19 | Ici Ltd | Coumaran derivatives |
| SE7308238L (es) * | 1973-06-15 | 1974-12-13 | Sandoz Ag | |
| US3959475A (en) * | 1973-12-12 | 1976-05-25 | American Hoechst Corporation | Substituted 1,3-dihydrospiro(isobenzofuran)s |
| US4166120A (en) * | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines |
| US4166119A (en) * | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines |
| US4263317A (en) * | 1979-09-06 | 1981-04-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s |
| US4404221A (en) * | 1981-10-19 | 1983-09-13 | Hoechst-Roussel Pharmaceuticals Inc. | 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use |
-
1982
- 1982-09-13 US US06/416,446 patent/US4517311A/en not_active Expired - Fee Related
- 1982-10-15 EP EP82109537A patent/EP0077536B1/en not_active Expired
- 1982-10-15 DE DE8282109537T patent/DE3272035D1/de not_active Expired
- 1982-10-16 KR KR8204672A patent/KR880001814B1/ko not_active Expired
- 1982-10-18 ES ES516610A patent/ES516610A0/es active Granted
- 1982-10-18 AU AU89440/82A patent/AU564232B2/en not_active Ceased
- 1982-10-18 IL IL67011A patent/IL67011A/xx unknown
-
1984
- 1984-02-01 ES ES529362A patent/ES529362A0/es active Granted
- 1984-02-01 ES ES529361A patent/ES8507531A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US4517311A (en) | 1985-05-14 |
| ES529361A0 (es) | 1985-09-01 |
| KR880001814B1 (ko) | 1988-09-19 |
| IL67011A0 (en) | 1983-02-23 |
| EP0077536A3 (en) | 1983-08-03 |
| ES8404341A1 (es) | 1984-04-16 |
| ES8506688A1 (es) | 1985-07-16 |
| ES516610A0 (es) | 1984-04-16 |
| ES529362A0 (es) | 1985-07-16 |
| KR840001967A (ko) | 1984-06-07 |
| EP0077536B1 (en) | 1986-07-16 |
| DE3272035D1 (en) | 1986-08-21 |
| AU8944082A (en) | 1983-04-28 |
| AU564232B2 (en) | 1987-08-06 |
| IL67011A (en) | 1988-07-31 |
| EP0077536A2 (en) | 1983-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960506 |