ES8600390A1 - Un procedimiento para la preparacion de sustratos de d-amino acido oxidasa - Google Patents

Un procedimiento para la preparacion de sustratos de d-amino acido oxidasa

Info

Publication number
ES8600390A1
ES8600390A1 ES538309A ES538309A ES8600390A1 ES 8600390 A1 ES8600390 A1 ES 8600390A1 ES 538309 A ES538309 A ES 538309A ES 538309 A ES538309 A ES 538309A ES 8600390 A1 ES8600390 A1 ES 8600390A1
Authority
ES
Spain
Prior art keywords
amino acid
formula
acid oxidase
amino
novel substrates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538309A
Other languages
English (en)
Other versions
ES538309A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of ES8600390A1 publication Critical patent/ES8600390A1/es
Publication of ES538309A0 publication Critical patent/ES538309A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE SUSTRATOS DE D-AMINO ACIDO OXIDASA.COMPRENDE: N-ALQUILAR UN DERIVADO DEL AGENTE TERAPEUTICO DE FORMULA (II) EN DONDE R7 ES H, C6H5C-, U OTROS, R6 ES ALQUILO INFERIOR QUE TIENE DE C 1 A 4 Y R8 ES ARILO, TENIENDO DICHO DERIVADO D-ACIDO LA FORMULA (III) EN DONDE X ES HALOGENO, TOSILATO O MOSILATO, Y R4 ES H O UN GRUPO ALQUILO INFERIOR DE CADENA LINEAL O RAMIFICADA DE C 1 A 6, EN PRESENCIA DE UN BASE,DURANTE UN PERIODO DE 1 A 24 HORAS, A UNA TEMPERATURA DE 0JC A 100JC; SEPARAR LOS GRUPOS PROTECTORES DE ESTER Y AMINA, PARA FORMAR EL SUSTRATO DE D-AMINO ACIDO OXIDASA DE FORMULA (I) EN DONDE R ES H, -CH3, CH3CH2-, U OTROS, Y R, ES EL RESTO DES-AMINO DE UN AGENTE TERAPEUTICO QUE LLEVA EL AMINO.SE UTILIZAN PARA EL TRATAMIENTO DE LA HIPERTENSION.
ES538309A 1983-12-06 1984-12-05 Un procedimiento para la preparacion de sustratos de d-amino acido oxidasa Granted ES538309A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55864383A 1983-12-06 1983-12-06
US66934284A 1984-11-09 1984-11-09

Publications (2)

Publication Number Publication Date
ES8600390A1 true ES8600390A1 (es) 1985-09-16
ES538309A0 ES538309A0 (es) 1985-09-16

Family

ID=27071801

Family Applications (1)

Application Number Title Priority Date Filing Date
ES538309A Granted ES538309A0 (es) 1983-12-06 1984-12-05 Un procedimiento para la preparacion de sustratos de d-amino acido oxidasa

Country Status (12)

Country Link
EP (1) EP0146067A3 (es)
KR (1) KR900004397B1 (es)
AU (1) AU575602B2 (es)
DK (1) DK580884A (es)
ES (1) ES538309A0 (es)
FI (1) FI844793L (es)
GR (1) GR81170B (es)
HU (1) HU192086B (es)
IL (1) IL73795A0 (es)
NO (1) NO844858L (es)
NZ (1) NZ210420A (es)
PT (1) PT79623A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4694082A (en) * 1985-09-23 1987-09-15 Monsanto Company Compound 1,4-diisopropyl-2,5-diketopiperazine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1074480A (en) * 1964-07-29 1967-07-05 Pfizer & Co C Amino acid derivatives and method of preparation
US3856857A (en) * 1970-02-13 1974-12-24 En Nom Collectif Science Union Amino acids and their derivatives
DE2021620C3 (de) * 1970-05-02 1980-02-07 Boehringer Sohn Ingelheim Neue Phenylaminoalkane und Verfahren zu deren Herstellung
GB1406993A (en) * 1971-10-09 1975-09-24 Beecham Group Ltd Amino acid derivatives
GB1360457A (en) * 1972-10-02 1974-07-17 Beecham Group Ltd Amino acid derivatives
EP0035868A1 (en) * 1980-03-07 1981-09-16 Takeda Chemical Industries, Ltd. Bicyclic compounds, their production and use
US4425280A (en) * 1981-03-30 1984-01-10 Ferro Corporation Metal amino acids
US4399121A (en) * 1981-11-04 1983-08-16 Miles Laboratories, Inc. Iodothyronine immunogens and antibodies
US4555503A (en) * 1982-05-05 1985-11-26 Merck & Co., Inc. N2 -(Substituted)carboxymethyl-N6 -(substituted)-lysyl-and αε-aminoalkyl)glycyl amino acid antihypertensive agents

Also Published As

Publication number Publication date
AU575602B2 (en) 1988-08-04
AU3628484A (en) 1985-06-13
NO844858L (no) 1985-06-07
DK580884D0 (da) 1984-12-05
IL73795A0 (en) 1985-03-31
EP0146067A2 (en) 1985-06-26
DK580884A (da) 1985-06-07
NZ210420A (en) 1988-04-29
FI844793A0 (fi) 1984-12-05
GR81170B (en) 1985-04-03
ES538309A0 (es) 1985-09-16
KR900004397B1 (ko) 1990-06-25
HUT36082A (en) 1985-08-28
KR850004579A (ko) 1985-07-25
HU192086B (en) 1987-05-28
PT79623A (en) 1985-01-01
FI844793A7 (fi) 1985-06-07
FI844793L (fi) 1985-06-07
EP0146067A3 (en) 1987-03-04

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