ES8601123A1 - Procedimiento para la produccion de derivados de 1-sulfo-2-oxoacetidina - Google Patents

Procedimiento para la produccion de derivados de 1-sulfo-2-oxoacetidina

Info

Publication number
ES8601123A1
ES8601123A1 ES529774A ES529774A ES8601123A1 ES 8601123 A1 ES8601123 A1 ES 8601123A1 ES 529774 A ES529774 A ES 529774A ES 529774 A ES529774 A ES 529774A ES 8601123 A1 ES8601123 A1 ES 8601123A1
Authority
ES
Spain
Prior art keywords
compound
formula
oxoacetidine
sulfo
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529774A
Other languages
English (en)
Other versions
ES529774A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8601123A1 publication Critical patent/ES8601123A1/es
Publication of ES529774A0 publication Critical patent/ES529774A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PRODUCCION DE DERIVADOS DE 1-SULFO-2-OXOACETIDINA. CONSISTE EN HACER REACCIONAR EL COMPUESTO DE FORMULA (II) CON EL COMPUESTO DE FORMULA (III) EN UN DISOLVENTE ORGANICO INERTE COMO CLORURO DE METILENO CLOROFORMO TETRAHIDROFURANO DIOXANO ACETATO DE ETILO ACETONA O EN UN DISOLVENTE APROTICO COMO ACETONITRILO DIMETILFORMAMIDA O DIMETILACETAMIDA A UNA TEMPERATURA DE 0 A 20JC Y EN PRESENCIA DE UNA AMINA ORGANICA COMO TRIETILAMINA O UN BICARBONATO ALCALINO COMO CO3HNA PARA OBTENER UN COMPUESTO DE FORMULA (I) O UNA SAL DE ADICION FARMACEUTICAMENTE ACEPTABLE. SIENDO: NOR1 EN FORMA SIN SI R4F2-AMINO-4-OXAZOLILO Y OTROS O R21FHIDROXIIMINOMETILO Y OTROS; NOR10 EN FORMA SIN; R1 H ALQUILO INFERIOR Y OTROS; R4 HETEROCICLO AROMATICO DE C 5 A 6 Y OTROS; R21 HIDROXIIMINOMETILO Y OTROS. SE UTILIZAN COMO ANTIBACTERIANOS CONTRA GERMENES GRAM-NEGATIVOS.
ES529774A 1982-06-03 1984-02-16 Procedimiento para la produccion de derivados de 1-sulfo-2-oxoacetidina Granted ES529774A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH341782 1982-06-03
CH341682 1982-06-03
CH220183 1983-04-25

Publications (2)

Publication Number Publication Date
ES8601123A1 true ES8601123A1 (es) 1985-11-01
ES529774A0 ES529774A0 (es) 1985-11-01

Family

ID=27173519

Family Applications (2)

Application Number Title Priority Date Filing Date
ES522886A Granted ES522886A0 (es) 1982-06-03 1983-06-01 "procedimiento para la preparacion de derivados de 1-sulfo-2-oxoacetidina"
ES529774A Granted ES529774A0 (es) 1982-06-03 1984-02-16 Procedimiento para la produccion de derivados de 1-sulfo-2-oxoacetidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES522886A Granted ES522886A0 (es) 1982-06-03 1983-06-01 "procedimiento para la preparacion de derivados de 1-sulfo-2-oxoacetidina"

Country Status (14)

Country Link
EP (1) EP0096297B1 (es)
AU (1) AU558593B2 (es)
DE (1) DE3377061D1 (es)
DK (1) DK241883A (es)
ES (2) ES522886A0 (es)
FI (1) FI832004L (es)
GR (1) GR78269B (es)
IE (1) IE55402B1 (es)
IL (1) IL68817A (es)
MC (1) MC1527A1 (es)
NO (1) NO832001L (es)
NZ (1) NZ204386A (es)
PH (2) PH18877A (es)
PT (1) PT76809A (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA19602A1 (fr) * 1981-09-30 1983-04-01 Ciba Geigy Ag Composes d'amino-oxazolyle, procede pour leur preparation, preparations pharmaceutiques qui contiennent ces composes, et leur application
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
CA1263399A (en) * 1984-12-19 1989-11-28 Hoffmann-La Roche Limited Process for the manufacture of aminothiazole acetic acid derivatives
US4883869A (en) * 1984-12-20 1989-11-28 The Upjohn Company Novel beta-lactams containing amino acid substituents
US4837318A (en) * 1985-05-09 1989-06-06 The Upjohn Company Carbonate substituted monobactams as antibiotics
JPS62502825A (ja) * 1985-05-09 1987-11-12 ジ・アップジョン・カンパニ− 抗生物質としてのカ−ボネ−ト置換モノバクタム
US4675398A (en) * 1985-08-16 1987-06-23 E. R. Squibb & Sons, Inc. Copper-mediated oximation reaction
US4684722A (en) * 1986-01-06 1987-08-04 E. R. Squibb & Sons, Inc. Monosulfactams
YU44630B (en) * 1987-06-11 1990-10-31 Krka Process for preparing 6-/d(-)-alpha(4-ethyl-2,3-dioxo-1-piperazincarboxamido)-phenylacetamido/phenicilanic acid
US5015737A (en) * 1987-07-22 1991-05-14 The Upjohn Company Therapeutically useful beta-lactams
WO1992007840A1 (fr) * 1990-11-02 1992-05-14 Taisho Pharmaceutical Co., Ltd. Derive de thioester de thiazole
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
AT406773B (de) * 1998-04-02 2000-08-25 Biochemie Gmbh Neues salz von 7-(2-(aminothiazol-4yl)-2-
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
AU2009273324A1 (en) * 2008-07-24 2010-01-28 F. Hoffmann-La Roche Ag 4,5-dihydro-oxazol-2-yl derivatives
CN106164072B (zh) 2014-03-24 2019-10-01 诺华股份有限公司 用于治疗细菌感染的单环内酰胺有机化合物
ES2817537T3 (es) 2015-09-23 2021-04-07 Novartis Ag Sales y formas sólidas de un antibiótico monobactámico
ES2912656T3 (es) 2017-08-02 2022-05-26 Novartis Ag Proceso para preparar ácido 1-(((Z)-(1-(2-aminotiazol-4-il)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-il)metil)-1-sulfoacetidin-3-il)amino)etiliden)amino)oxi)ciclopropano carboxílico

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009008A3 (de) * 1978-09-08 1980-05-14 Ciba-Geigy Ag Cephalosporinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE3069587D1 (en) * 1979-06-08 1984-12-13 Takeda Chemical Industries Ltd 1-sulpho-2-oxoazetidine derivatives, their production and pharmaceutical compositions thereof
NZ196202A (en) * 1980-02-07 1984-07-31 Squibb & Sons Inc Beta-lactam antibiotics (of azetidine-sulphonic acid type)
DE3165922D1 (en) * 1980-03-28 1984-10-18 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
EP0059683A3 (de) * 1981-02-27 1982-12-01 Ciba-Geigy Ag 7-Acylamido-3-cephem-4-carbonsäureverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
EP0075104A3 (de) * 1981-09-23 1984-11-28 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cephalosporinderivate, Verfahren zu deren Herstellung und Zwischenprodukte dafür sowie entsprechende pharmazeutische Präparate
MA19602A1 (fr) * 1981-09-30 1983-04-01 Ciba Geigy Ag Composes d'amino-oxazolyle, procede pour leur preparation, preparations pharmaceutiques qui contiennent ces composes, et leur application
US4379787A (en) * 1981-10-02 1983-04-12 Eli Lilly And Company Oximino-substituted cephalosporin compounds
FR2515182B1 (fr) * 1981-10-23 1986-05-09 Roussel Uclaf Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine 1-sulfamique, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation

Also Published As

Publication number Publication date
ES8504120A1 (es) 1985-04-16
PH21897A (en) 1988-04-07
FI832004A0 (fi) 1983-06-03
IE55402B1 (en) 1990-09-12
ES522886A0 (es) 1985-04-16
PH18877A (en) 1985-10-22
GR78269B (es) 1984-09-26
MC1527A1 (fr) 1984-04-13
PT76809A (en) 1983-07-01
DK241883D0 (da) 1983-05-27
NO832001L (no) 1983-12-05
DE3377061D1 (en) 1988-07-21
DK241883A (da) 1983-12-04
EP0096297A2 (de) 1983-12-21
FI832004A7 (fi) 1983-12-04
NZ204386A (en) 1986-12-05
EP0096297A3 (en) 1984-04-11
AU1506883A (en) 1983-12-15
IL68817A0 (en) 1983-09-30
FI832004L (fi) 1983-12-04
EP0096297B1 (de) 1988-06-15
IL68817A (en) 1989-08-15
IE831305L (en) 1983-12-05
ES529774A0 (es) 1985-11-01
AU558593B2 (en) 1987-02-05

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