ES8601187A1 - Un procedimiento para preparar un derivado de carbostirilo - Google Patents

Un procedimiento para preparar un derivado de carbostirilo

Info

Publication number
ES8601187A1
ES8601187A1 ES532537A ES532537A ES8601187A1 ES 8601187 A1 ES8601187 A1 ES 8601187A1 ES 532537 A ES532537 A ES 532537A ES 532537 A ES532537 A ES 532537A ES 8601187 A1 ES8601187 A1 ES 8601187A1
Authority
ES
Spain
Prior art keywords
agents
carbostyril
carbostyril derivatives
useful
hypotensive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532537A
Other languages
English (en)
Other versions
ES532537A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP15409082A external-priority patent/JPS5962585A/ja
Priority claimed from JP57213167A external-priority patent/JPS59104378A/ja
Priority claimed from JP58114679A external-priority patent/JPS606685A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES532537A0 publication Critical patent/ES532537A0/es
Publication of ES8601187A1 publication Critical patent/ES8601187A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CARBOSTIRILO Y DE SUS SALES DE FORMULA (I) EN LA QUE RF R1F Y R2F PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN LAS QUE RE R1E R2E R4 Y R5 PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE A UNA TEMPERATURA COMPRENDIDA ENTRE C20JC Y 200JC DURANTE UN PERIODO DE TIEMPO DE 10 MINUTOS A 20 HORAS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA TROMBOSIS COMO VASODILATADORES CORONARIOS Y AGENTES HIPOTENSORES.
ES532537A 1982-09-03 1984-05-16 Un procedimiento para preparar un derivado de carbostirilo Expired ES8601187A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP15409082A JPS5962585A (ja) 1982-09-03 1982-09-03 カルボスチリル誘導体
JP57213167A JPS59104378A (ja) 1982-12-03 1982-12-03 カルボスチリル誘導体
JP58114679A JPS606685A (ja) 1983-06-24 1983-06-24 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
ES532537A0 ES532537A0 (es) 1985-10-16
ES8601187A1 true ES8601187A1 (es) 1985-10-16

Family

ID=27312797

Family Applications (4)

Application Number Title Priority Date Filing Date
ES525346A Granted ES525346A0 (es) 1982-09-03 1983-09-02 Un derivado de carbostirilo.
ES532536A Expired ES8505998A1 (es) 1982-09-03 1984-05-16 Un procedimiento para preparar un derivado de carbostirilo
ES532537A Expired ES8601187A1 (es) 1982-09-03 1984-05-16 Un procedimiento para preparar un derivado de carbostirilo
ES532538A Expired ES8506697A1 (es) 1982-09-03 1984-05-16 Un procedimiento para preparar un derivado de carbostirilo

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES525346A Granted ES525346A0 (es) 1982-09-03 1983-09-02 Un derivado de carbostirilo.
ES532536A Expired ES8505998A1 (es) 1982-09-03 1984-05-16 Un procedimiento para preparar un derivado de carbostirilo

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES532538A Expired ES8506697A1 (es) 1982-09-03 1984-05-16 Un procedimiento para preparar un derivado de carbostirilo

Country Status (11)

Country Link
US (1) US4564619A (es)
KR (1) KR910000181B1 (es)
CA (1) CA1252469A (es)
CH (1) CH655110A5 (es)
DE (1) DE3331808A1 (es)
ES (4) ES525346A0 (es)
FR (1) FR2532648B1 (es)
GB (1) GB2127402B (es)
IT (1) IT1193145B (es)
NL (1) NL8303066A (es)
SE (1) SE455503B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1292234C (en) * 1984-05-29 1991-11-19 Simon Fraser Campbell Heterocyclic-substituted quinolone inotropic agents
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
DK167187A (da) * 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
KR100305515B1 (ko) * 1999-02-04 2001-09-24 이순금 메주의 제조방법
NL1012886C1 (nl) * 1999-08-23 2001-02-26 Rephartox 1,4-Dihydropyridine-5-carbonzuuresterderivaten en werkwijze voor de bereiding ervan.
KR100422242B1 (ko) * 2001-07-20 2004-03-12 농업회사법인(주)맛가마식품 중공봉형상 메주와 이를 이용한 간장 및 된장 제조방법과제조용 장독
CN1720243A (zh) * 2002-10-07 2006-01-11 瓦卡尔治疗公司 具有同时阻滞l－型钙通道和抑制3型磷酸二酯酶活性能力的二氢吡啶化合物
US20070066619A1 (en) * 2002-10-07 2007-03-22 Artesian Therapeutics, Inc. Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
NL1028564C2 (nl) * 2005-03-17 2006-09-20 Rademaker Holding B V Toepassing van een coumarine-groep omvattende derivaten voor de bereiding van een antiviraal middel, coumarine-group omvattende derivaten, een werkwijze voor de bereiding daarvan, en farmaceutische preparaten die deze bevatten.
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20070244143A1 (en) * 2006-03-08 2007-10-18 Braincells, Inc Modulation of neurogenesis by nootropic agents
JP2009536667A (ja) * 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
AU2007292848A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
AU2007299920A1 (en) * 2006-09-19 2008-03-27 Braincells, Inc. PPAR Mediated Modulation of Neurogenesis
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971797A (en) * 1973-06-15 1976-07-27 Merck & Co., Inc. S,S'-bis(pyridylmethyl)-carbonodithioates
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
DE2659665A1 (de) * 1976-12-30 1978-07-13 Nattermann A & Cie Neue 1,4-dihydropyridin-derivate
JPS5387368A (en) * 1977-01-12 1978-08-01 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5390270A (en) * 1977-01-14 1978-08-08 Otsuka Pharmaceut Co Ltd Carbostryl derivs.
NZ187452A (en) * 1977-06-10 1980-05-27 Otsuka Pharma Co Ltd N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation
DE2805404A1 (de) * 1978-02-09 1979-08-16 Merck Patent Gmbh 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung
IT1097538B (it) * 1978-07-17 1985-08-31 Medea Res Srl Processo per la preparazione del 2,6-dimetil-4-3(3-nitrofenil)-3-metossicarbonil-1,4-didropiridin-5-carbossilati di 2(n-benzil-n-metilammino)
CA1117117A (en) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same
DE3034237A1 (de) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
JPS5777676A (en) * 1980-10-31 1982-05-15 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS57200386A (en) * 1981-06-04 1982-12-08 Yoshitomi Pharmaceut Ind Ltd Novel 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salts

Also Published As

Publication number Publication date
FR2532648A1 (fr) 1984-03-09
US4564619A (en) 1986-01-14
DE3331808A1 (de) 1984-03-08
IT1193145B (it) 1988-06-02
ES8502686A1 (es) 1985-01-16
SE8304737L (sv) 1984-03-04
ES532538A0 (es) 1985-07-16
SE8304737D0 (sv) 1983-09-02
ES532536A0 (es) 1985-06-16
GB2127402B (en) 1987-01-14
SE455503B (sv) 1988-07-18
ES532537A0 (es) 1985-10-16
ES8505998A1 (es) 1985-06-16
NL8303066A (nl) 1984-04-02
GB8323542D0 (en) 1983-10-05
CA1252469A (en) 1989-04-11
GB2127402A (en) 1984-04-11
ES8506697A1 (es) 1985-07-16
ES525346A0 (es) 1985-01-16
KR910000181B1 (ko) 1991-01-21
FR2532648B1 (fr) 1989-07-21
CH655110A5 (de) 1986-03-27
IT8367922A0 (it) 1983-09-05
KR850000402A (ko) 1985-02-27

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303