ES8601206A1 - Procedimiento para preparar amidinas ciclicas sustituidas aromaticas. - Google Patents

Procedimiento para preparar amidinas ciclicas sustituidas aromaticas.

Info

Publication number
ES8601206A1
ES8601206A1 ES526418A ES526418A ES8601206A1 ES 8601206 A1 ES8601206 A1 ES 8601206A1 ES 526418 A ES526418 A ES 526418A ES 526418 A ES526418 A ES 526418A ES 8601206 A1 ES8601206 A1 ES 8601206A1
Authority
ES
Spain
Prior art keywords
inclusive
carbon atoms
halogen
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526418A
Other languages
English (en)
Other versions
ES526418A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES526418A0 publication Critical patent/ES526418A0/es
Publication of ES8601206A1 publication Critical patent/ES8601206A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR AMIDINAS CICLICAS SUSTITUIDAS AROMATICAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN DERIVADO DE ANILINA DE FORMULA (III) PARA OBTENER COMPUESTOS DE FORMULA (I) O SUS SALES FARMACOLOGICAMENTE ACEPTABLES. SIENDO: R1 R2 Y R3 QUE SON IGUALES O DIFERENTES H ALQUILO DE C 1 A 6 HAL CON LA CONDICION DE QUE R1 R2 NO SON H A LA VEZ; R4 Y R5 SON UNO H Y EL OTRO EL RADICAL -NR6 R7; R6 Y R7 IGUALES O DIFERENTES H ALQUILO DE C 1 A 6 ALCOXICARBONILO DE C 2 A 7 Y OTROS Y JUNTOS FORMAN -(CH2)P- O -(CH2)MCO-; X HALOGENO; M ES 3 O 4; N ES 1 2 O 3; Y P ES 4 O 5. SE UTILIZA EN FARMACOLOGIA PARA EL TRATAMIENTO DE DIARREAS DE DIVERSO ORIGEN.
ES526418A 1982-10-12 1983-10-11 Procedimiento para preparar amidinas ciclicas sustituidas aromaticas. Expired ES8601206A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/433,922 US4533739A (en) 1982-10-12 1982-10-12 2-[(Aminophenyl and amidophenyl)amino]-1-azacycloalkanes having antidiarrheal activity

Publications (2)

Publication Number Publication Date
ES526418A0 ES526418A0 (es) 1985-11-01
ES8601206A1 true ES8601206A1 (es) 1985-11-01

Family

ID=23722091

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526418A Expired ES8601206A1 (es) 1982-10-12 1983-10-11 Procedimiento para preparar amidinas ciclicas sustituidas aromaticas.

Country Status (7)

Country Link
US (1) US4533739A (es)
EP (1) EP0111095B1 (es)
JP (1) JPS5989625A (es)
AU (1) AU2005783A (es)
DE (1) DE3368413D1 (es)
ES (1) ES8601206A1 (es)
ZA (1) ZA837551B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8315495D0 (en) * 1983-06-06 1983-07-13 Sumitomo Chemical Co Fungicidal aniline derivatives
DE3343815A1 (de) * 1983-12-03 1985-06-13 Hoechst Ag, 6230 Frankfurt Neue bisamidindiphenylderivate, ein verfahren zu ihrer herstellung und ihre verwendung als chemotherapeutika
US4579951A (en) * 1984-03-19 1986-04-01 G. D. Searle & Co. Substituted (azacycloalk-2-yl)iminophenols and esters thereof
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
AU688811B2 (en) * 1993-10-21 1998-03-19 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
ES2206571T3 (es) * 1995-04-20 2004-05-16 G.D. SEARLE & CO. Agentes de amidino ciclico utiles como inhibidores de la oxido nitrico sintasa.
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5888494A (en) * 1996-03-12 1999-03-30 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic and pruritic conditions therewith
US5667773A (en) * 1996-03-12 1997-09-16 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
CA2333691A1 (en) 1998-06-10 1999-12-16 G.D. Searle & Co. Heterobicyclic and tricyclic nitric oxide synthase inhibitors
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
PL2368554T3 (pl) 2003-04-08 2015-05-29 Progenics Pharm Inc Preparaty farmaceutyczne zawierające metylonaltrekson
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
MX2009010550A (es) 2007-03-29 2009-12-14 Progenics Pharm Inc Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
JP5469593B2 (ja) 2007-03-29 2014-04-16 ワイス・エルエルシー 末梢性オピオイド受容体アンタゴニストおよびその使用
WO2008121348A2 (en) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
AU2008349873B2 (en) 2008-02-06 2014-02-13 Progenics Pharmaceuticals, Inc. Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
RS55061B1 (sr) * 2011-04-19 2016-12-30 Univ Strasbourg Novi derivati amino-pirolina i njihova upotreba u prevenciji i/ili lečenju metaboličkog sindroma

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670859A1 (de) * 1967-04-24 1971-03-11 Bayer Ag Verfahren zur Herstellung von 2-Phenyl-imino-1-azacycloalkanen
DE1937665A1 (de) * 1969-07-24 1971-01-28 Bayer Ag Verfahren zur Herstellung von 2-Aryl-imino-pyrrolidinen
BE757934A (fr) * 1969-10-23 1971-04-23 Bayer Ag Nouvelles 2-phenylamino-delta 1-pyrrolines et leur application comme acaricides
DE2029297A1 (de) * 1970-06-13 1971-12-30 Farbenfabriken Bayer Ag, 5090 Leverkusen Neue Aminophenyl-cycloamidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US3911010A (en) * 1970-06-13 1975-10-07 Bayer Ag Aminophenylamidines, their production and their pharmaceutical use
JPS5759103B2 (es) * 1974-03-18 1982-12-13 Tokyo Shibaura Electric Co

Also Published As

Publication number Publication date
EP0111095B1 (en) 1986-12-17
ZA837551B (en) 1984-11-28
US4533739A (en) 1985-08-06
ES526418A0 (es) 1985-11-01
EP0111095A1 (en) 1984-06-20
AU2005783A (en) 1984-04-19
JPS5989625A (ja) 1984-05-23
DE3368413D1 (en) 1987-01-29

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