ES8601236A1 - Un procedimiento para la preparacion de derivados peptidicos - Google Patents

Un procedimiento para la preparacion de derivados peptidicos

Info

Publication number
ES8601236A1
ES8601236A1 ES534186A ES534186A ES8601236A1 ES 8601236 A1 ES8601236 A1 ES 8601236A1 ES 534186 A ES534186 A ES 534186A ES 534186 A ES534186 A ES 534186A ES 8601236 A1 ES8601236 A1 ES 8601236A1
Authority
ES
Spain
Prior art keywords
peptide derivatives
general formula
salts
intermediates
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534186A
Other languages
English (en)
Other versions
ES534186A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838318855A external-priority patent/GB8318855D0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES534186A0 publication Critical patent/ES534186A0/es
Publication of ES8601236A1 publication Critical patent/ES8601236A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS PEPTIDICOS DE FORMULA GENERAL (I) EN LA QUE R REPRESENTA UN GRUPO DE HIDROCARBONO CICLICO; M REPRESENTA UN NUMERO ENTERO COMPRENDIDO ENTRE 2 Y 6; Y REPRESENTA UN GRUPO CARBONILO SULFONILO O METILENO; Y N ES CERO UNO O DOS Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) EN LA QUE R M Y Y N TIENEN LOS SIGNIFICADOS YA MENCIONADOS CON UN DERIVADO REACTIVO DE UN ACIDO DE FORMULA GENERAL (III). DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES DEGENERATIVAS TALES COMO EL ANFISEMA Y LA ARTRITIS Y DE APLICACION TAMBIEN EN EL TRATAMIENTO DE LOS ESTADOS INFLAMATORIOS.
ES534186A 1983-07-12 1984-07-11 Un procedimiento para la preparacion de derivados peptidicos Expired ES8601236A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838318855A GB8318855D0 (en) 1983-07-12 1983-07-12 Peptide derivatives
GB848411635A GB8411635D0 (en) 1983-07-12 1984-05-08 Peptide derivatives

Publications (2)

Publication Number Publication Date
ES534186A0 ES534186A0 (es) 1985-11-01
ES8601236A1 true ES8601236A1 (es) 1985-11-01

Family

ID=26286589

Family Applications (1)

Application Number Title Priority Date Filing Date
ES534186A Expired ES8601236A1 (es) 1983-07-12 1984-07-11 Un procedimiento para la preparacion de derivados peptidicos

Country Status (11)

Country Link
US (1) US4623639A (es)
EP (1) EP0133225B1 (es)
AU (1) AU578898B2 (es)
CA (1) CA1267499A (es)
DE (1) DE3474670D1 (es)
DK (1) DK304684A (es)
ES (1) ES8601236A1 (es)
IE (1) IE57747B1 (es)
IL (1) IL72345A (es)
NZ (1) NZ208796A (es)
PH (1) PH23381A (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124317B1 (en) * 1983-04-27 1990-04-11 Ici Americas Inc. Proline derivatives
DD248961A1 (de) * 1984-05-22 1987-08-26 Akad Wissenschaften Ddr Verfahren zur herstellung wundheilungsfoerdernder praeparationen
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
GB8613704D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro keto compounds
ZA897515B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
US5736520A (en) * 1988-10-07 1998-04-07 Merrell Pharmaceuticals Inc. Peptidase inhibitors
US5162500A (en) * 1989-04-15 1992-11-10 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Poststatin and related compounds or salts thereof
DK53291D0 (da) * 1991-03-25 1991-03-25 Carlbiotech Ltd As Smaa peptider og peptidrelaterede stoffer samt farmaceutiske praeparater indeholdende saadanne forbindelser
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
DE69522940T2 (de) * 1994-06-02 2002-04-04 Merrell Pharmaceuticals Inc., Cincinnati Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren
NZ284766A (en) * 1994-06-02 1998-06-26 Merrell Pharma Inc Perfluoro amino ketones; medicaments as elastase inhibitors
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
CN114008068A (zh) * 2019-07-01 2022-02-01 巴斯夫欧洲公司 稳定酶的肽缩醛

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124317B1 (en) * 1983-04-27 1990-04-11 Ici Americas Inc. Proline derivatives

Also Published As

Publication number Publication date
CA1267499A (en) 1990-04-03
EP0133225A2 (de) 1985-02-20
AU578898B2 (en) 1988-11-10
IL72345A (en) 1988-05-31
DE3474670D1 (en) 1988-11-24
AU3039384A (en) 1985-01-17
IE841782L (en) 1985-01-12
NZ208796A (en) 1989-01-27
IE57747B1 (en) 1993-03-24
EP0133225A3 (en) 1985-10-02
PH23381A (en) 1989-07-26
US4623639A (en) 1986-11-18
ES534186A0 (es) 1985-11-01
DK304684A (da) 1985-01-13
IL72345A0 (en) 1984-11-30
DK304684D0 (da) 1984-06-21
EP0133225B1 (de) 1988-10-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303