ES8601948A1 - Un metodo para preparar compuestos de fenilpiperazina sustituida. - Google Patents

Un metodo para preparar compuestos de fenilpiperazina sustituida.

Info

Publication number
ES8601948A1
ES8601948A1 ES537961A ES537961A ES8601948A1 ES 8601948 A1 ES8601948 A1 ES 8601948A1 ES 537961 A ES537961 A ES 537961A ES 537961 A ES537961 A ES 537961A ES 8601948 A1 ES8601948 A1 ES 8601948A1
Authority
ES
Spain
Prior art keywords
processes
production
compounds
compounds suitable
antihypertensive agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537961A
Other languages
English (en)
Other versions
ES537961A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES8601948A1 publication Critical patent/ES8601948A1/es
Publication of ES537961A0 publication Critical patent/ES537961A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO PARA PREPARAR COMPUESTOS DE FENILPIPERAZINA SUSTITUIDA. CONSISTENTE EN HACER REACCIONAR COMPUESTOS DE FORMULA ESTRUCTURAL (III) CON 5,5-DIMETIL-1,3-CICLOHEXANODIONA PARA FORMAR UN COMPUESTO DE FORMULA (I). DONDE A REPRESENTA LAS FORMULAS (II), N - 2 3 O 4, Y R1 ES HIDROGENO, ALQUILO O ALCOXI CON UN NUMERO DE ATOMOS DE CARBONO COMPRENDIDO ENTRE 1 Y 6. ESTOS COMPUESTOS FORMAN SALES FARMACEUTICAMENTE ACEPTABLES CON ACIDOS ORGANICOS E INORGANICOS. ACIDOS ADECUADOS PARA LA FORMACION DE SALES SON CLORHIDRICO, SULFURICO, FOSFORICO, ACETICO, CITRICO, ETC. DE APLICACION EN EL TRATAMIENTO DE LA HIPERTENSION.
ES537961A 1982-06-22 1984-11-26 Un metodo para preparar compuestos de fenilpiperazina sustituida. Granted ES537961A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/391,198 US4452798A (en) 1982-06-22 1982-06-22 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents

Publications (2)

Publication Number Publication Date
ES8601948A1 true ES8601948A1 (es) 1985-11-01
ES537961A0 ES537961A0 (es) 1985-11-01

Family

ID=23545665

Family Applications (2)

Application Number Title Priority Date Filing Date
ES523462A Granted ES523462A0 (es) 1982-06-22 1983-06-21 Un metodo para preparar compuestos de fenilpiperazina sustituidos
ES537961A Granted ES537961A0 (es) 1982-06-22 1984-11-26 Un metodo para preparar compuestos de fenilpiperazina sustituida.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES523462A Granted ES523462A0 (es) 1982-06-22 1983-06-21 Un metodo para preparar compuestos de fenilpiperazina sustituidos

Country Status (17)

Country Link
US (1) US4452798A (es)
EP (1) EP0103357A3 (es)
JP (1) JPS5925376A (es)
KR (1) KR840005726A (es)
AU (1) AU537383B2 (es)
CA (1) CA1204754A (es)
DK (1) DK285683A (es)
ES (2) ES523462A0 (es)
FI (1) FI832241L (es)
GR (1) GR78313B (es)
HU (1) HU187941B (es)
IL (1) IL68942A (es)
NO (1) NO832254L (es)
NZ (1) NZ204658A (es)
PH (1) PH18302A (es)
PT (1) PT76899B (es)
ZA (1) ZA834500B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL114027A (en) 1994-06-08 1999-11-30 Lundbeck & Co As H 4-Phenyl piperazine (piperidine or tetrahydropyridine) derivatives serotinin 5-HT1A and dopamin D2 receptor ligand pharmaceutical compositions containing them
US6083950A (en) * 1997-11-13 2000-07-04 Ranbaxy Laboratories Limited 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers
PL345562A1 (en) * 1998-07-21 2001-12-17 Ranbaxy Lab Ltd Arylpiperazine derivatives useful as uroselective alpha1-adrenoceptor blockers
WO2000005206A1 (en) * 1998-07-21 2000-02-03 Ranbaxy Laboratories Limited Arylpiperazine derivatives useful as uro-selective alpha-1-adrenoceptor blockers

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037024A (en) * 1962-05-29 Chjchj
US2836595A (en) * 1958-05-27 Piperazine derivatives and process for
FR1012751A (fr) * 1949-01-24 1952-07-17 Rhone Poulenc Sa Nouveau dérivé de la pipérazine et de la quinoléïne et son procédé de préparation
ES291187A1 (es) * 1963-04-04 1964-01-16 American Cyanamid Co Un procedimiento para preparar piperazinas sustituidas
DE1445547C3 (de) * 1964-10-13 1975-04-30 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 3-Amino-2,1-benzoisothiazolen
US3494932A (en) * 1967-06-26 1970-02-10 American Cyanamid Co Aminoalkyl substituted aryl hydantoins
US3576808A (en) * 1967-09-15 1971-04-27 Miles Lab N-4-phenyl-1-piperazinylalkyl-5-phenyl-oxazolidinones
BE788280A (fr) * 1971-09-04 1973-02-28 Pfizer Nouvelles 1-(3-trifluoro-methyl-phenyl)-4-((amido cyclique)- alkyl) piperazines et composition pharmaceutique les contenant
US3806510A (en) * 1972-09-18 1974-04-23 Parke Davis & Co 4(orthoalkylthio phenyl)piperazin-1-yl hydantoins
US4038279A (en) * 1972-12-23 1977-07-26 Boehringer Ingelheim Gmbh N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
DE2263211A1 (de) * 1972-12-23 1974-07-04 Boehringer Sohn Ingelheim Neue arylpiperazine und verfahren zu ihrer herstellung
GB1443598A (en) * 1973-07-06 1976-07-21 Acraf 1- 3-acetylaminopropyl-4-2,5-dichlorophenyl-piperazine
US3892748A (en) * 1973-07-20 1975-07-01 Miles Lab 5,5-Diphenyl-3-(piperidino, tetrahydropyridyl-1-and piperazino)-hydantoins
US3879395A (en) * 1973-10-23 1975-04-22 Parke Davis & Co 3-(1-Piperazinylalkylamino)-2-cycloalken-1-one compounds and methods for their production
FR2306694A1 (fr) * 1975-04-07 1976-11-05 Parcor Derives de la piperazine
BE503170A (es) * 1975-09-02

Also Published As

Publication number Publication date
ES8504776A1 (es) 1985-04-16
KR840005726A (ko) 1984-11-16
NO832254L (no) 1983-12-23
ES537961A0 (es) 1985-11-01
US4452798A (en) 1984-06-05
DK285683D0 (da) 1983-06-21
IL68942A (en) 1987-02-27
FI832241A7 (fi) 1983-12-23
CA1204754A (en) 1986-05-20
AU1565883A (en) 1984-01-05
HU187941B (en) 1986-03-28
AU537383B2 (en) 1984-06-21
PT76899B (en) 1986-01-24
GR78313B (es) 1984-09-26
NZ204658A (en) 1985-12-13
EP0103357A3 (en) 1986-01-08
JPS5925376A (ja) 1984-02-09
IL68942A0 (en) 1983-10-31
EP0103357A2 (en) 1984-03-21
PH18302A (en) 1985-05-29
FI832241A0 (fi) 1983-06-20
FI832241L (fi) 1983-12-23
ES523462A0 (es) 1985-04-16
PT76899A (en) 1983-07-01
DK285683A (da) 1983-12-23
ZA834500B (en) 1984-03-28

Similar Documents

Publication Publication Date Title
ATE40994T1 (de) L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung.
ATE253581T1 (de) Verfahren zur herstellung von 3,4- alkylendioxythiophen-2,5-dicarbonsäurederivaten
ES8601924A1 (es) Un procedimiento para la preparacion de nuevas 2-amino-5-hidroxi-4-metilpirimidinas.
BG60270B1 (bg) Метод за получаване на 5н-2,3-бензодиазепинови производни
ES8800896A1 (es) Un procedimiento para preparar derivados de diamidas sustituidas con 7-oxabicicloheptano y sus analogos de prostaglandina
ES8506612A1 (es) Un metodo para producir un derivado de amina
ES8506677A1 (es) Un procedimiento para la preparacion de nuevos derivados de 8-cloro71,5-benzotiazepina.
ES8104275A1 (es) Un metodo para la preparacion de derivados de ftalimidina
ES476535A1 (es) Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos.
ES8801241A1 (es) Un procedimiento para preparar laudanos
ES8705871A1 (es) Un procedimiento para preparar un derivado de benzofurano
FR2367758A1 (fr) Procede pour la production de derives du furanne
ES8705384A1 (es) Procedimiento para preparar isomeros de derivados de prostaglandina
ES327312A1 (es) Procedimiento para la produccion de nuevos derivados de benzotiofeno.
ES8203376A1 (es) Procedimiento para obtener acidos 6-cloro- o 6-bromo-1,2-di-hidro-3h-pirrolo(1,2-a)pirrol-1-carboxilicos y sus derivados
KR920014781A (ko) N-플루오로피리디늄 염의 제조방법
ATE82569T1 (de) Herstellung von chinolincarbonsaeuren.
ES8800920A1 (es) Un procedimiento para preparar un derivado de 1,5-benzotiazepina
ES8703424A1 (es) Procedimiento para la obtencion de compuestos de amida
SE7704615L (sv) Sett att framstella nya 1,4-bensodioxanderivat
KR880009010A (ko) 신규한 테트라히드로 푸란의 5-옥시 유도체의 제조방법
AR241015A2 (es) "procedimiento para preparar acidos 16-fenoxiprostatrienoicos"
ES8706122A1 (es) Un procedimiento para la preparacion de agentes inotropicos de quinolona
ES8505962A1 (es) Un procedimiento para preparar nuevos derivados amidinicos de 4-fenilimidazol sustituido en la posicion 2
ATE61329T1 (de) Verfahren zur herstellung von rooperol, hypoxosid und deren derivaten.