ES8800920A1 - Un procedimiento para preparar un derivado de 1,5-benzotiazepina - Google Patents
Un procedimiento para preparar un derivado de 1,5-benzotiazepinaInfo
- Publication number
- ES8800920A1 ES8800920A1 ES556552A ES556552A ES8800920A1 ES 8800920 A1 ES8800920 A1 ES 8800920A1 ES 556552 A ES556552 A ES 556552A ES 556552 A ES556552 A ES 556552A ES 8800920 A1 ES8800920 A1 ES 8800920A1
- Authority
- ES
- Spain
- Prior art keywords
- derivative
- procedure
- benzotiazepine
- preparing
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UN DERIVADO DE 1,5-BENZOTIAZEPINA. CONSISTE EN DESACILAR UN COMPUESTO DE FORMULA (II) CON ACIDO CLORHIDRICO EN TETRAHIDROFURANO Y ENTRE 0J Y 100JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE DEL MISMO. SIENDO: R1, ALQUILO INFERIOR O ALCOXI INFERIOR; R2, ALQUILO INFERIOR; R3, ALCOXI INFERIOR, FLUOR Y OTRAS; R4, ALQUILO INFERIOR O FENILO; Y Q, H. SE UTILIZAN EN EL TRATAMIENTO TERAPEUTICO DE LA TROMBOSIS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8409259 | 1984-04-10 | ||
| GB848410949A GB8410949D0 (en) | 1984-04-28 | 1984-04-28 | 1 5-benzothiazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES556552A0 ES556552A0 (es) | 1987-12-01 |
| ES8800920A1 true ES8800920A1 (es) | 1987-12-01 |
Family
ID=26287601
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542126A Expired ES8705410A1 (es) | 1984-04-10 | 1985-04-10 | Un procedimiento para preparar un derivado de 1,5 beurotiarepina. |
| ES556552A Expired ES8800920A1 (es) | 1984-04-10 | 1986-06-24 | Un procedimiento para preparar un derivado de 1,5-benzotiazepina |
| ES556551A Expired ES8707217A1 (es) | 1984-04-10 | 1986-06-24 | Un procedimiento para preparar un derivado de 1,5-benzotiazepina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542126A Expired ES8705410A1 (es) | 1984-04-10 | 1985-04-10 | Un procedimiento para preparar un derivado de 1,5 beurotiarepina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES556551A Expired ES8707217A1 (es) | 1984-04-10 | 1986-06-24 | Un procedimiento para preparar un derivado de 1,5-benzotiazepina |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4594342A (es) |
| EP (1) | EP0158340B1 (es) |
| KR (1) | KR900005680B1 (es) |
| AT (1) | ATE40127T1 (es) |
| CA (1) | CA1218992A (es) |
| DE (1) | DE3567651D1 (es) |
| ES (3) | ES8705410A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2624117B1 (fr) * | 1987-12-08 | 1991-02-22 | Synthelabo | Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique |
| FR2630107B1 (fr) * | 1988-04-19 | 1990-06-08 | Synthelabo | Procede de preparation du (+) - (2s,3s) (amino-2 phenyl)thio)-3 hydroxy-2 (methoxy-4 phenyl)-3 propionate de methyle |
| US5002942A (en) * | 1988-07-25 | 1991-03-26 | Sankyo Company, Limited | 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders |
| IT1230057B (it) * | 1989-04-13 | 1991-09-27 | Zambon Spa | Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine |
| IT1240651B (it) * | 1990-05-17 | 1993-12-17 | Zambon Spa | Processo per la risoluzione di derivati glicidici |
| CA2049655C (en) * | 1990-09-17 | 1996-11-12 | Akio Odawara | Pharmaceutical composition for inhibiting platelet aggregation |
| US5378698A (en) * | 1991-10-21 | 1995-01-03 | Shionogi & Co., Ltd. | Benzothiazepine derivatives |
| US5637582A (en) * | 1992-10-23 | 1997-06-10 | Tanabe Seiyaku Co., Ltd. | Peripheral circulation improving agent |
| DK0595526T3 (da) * | 1992-10-23 | 1997-10-13 | Tanabe Seiyaku Co | Middel til at forbedre perifær cirkulation |
| IT1302261B1 (it) | 1998-09-24 | 2000-09-05 | Zambon Spa | Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3075967A (en) * | 1961-06-12 | 1963-01-29 | Olin Mathieson | Benzothiazines |
| US3341519A (en) * | 1965-04-28 | 1967-09-12 | Squibb & Sons Inc | Novel benzoxazines, benzothiazines, benzoxazepins and benzothiazepins |
| GB1236467A (en) * | 1967-10-28 | 1971-06-23 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
| US3562257A (en) * | 1967-10-28 | 1971-02-09 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
| JPS56156217A (en) * | 1980-05-02 | 1981-12-02 | Tanabe Seiyaku Co Ltd | Inhibitor against blood platelet agglutination |
| JPS56156218A (en) * | 1980-05-02 | 1981-12-02 | Tanabe Seiyaku Co Ltd | Inhibitor against blood platelet agglutination |
| US5708066A (en) * | 1995-03-01 | 1998-01-13 | E. I. Du Pont De Nemours And Company | Reaction curable composition and solid surface material |
-
1985
- 1985-03-22 US US06/715,115 patent/US4594342A/en not_active Expired - Lifetime
- 1985-04-09 CA CA000478614A patent/CA1218992A/en not_active Expired
- 1985-04-09 KR KR1019850002385A patent/KR900005680B1/ko not_active Expired
- 1985-04-10 ES ES542126A patent/ES8705410A1/es not_active Expired
- 1985-04-10 DE DE8585104342T patent/DE3567651D1/de not_active Expired
- 1985-04-10 AT AT85104342T patent/ATE40127T1/de not_active IP Right Cessation
- 1985-04-10 EP EP85104342A patent/EP0158340B1/en not_active Expired
-
1986
- 1986-06-24 ES ES556552A patent/ES8800920A1/es not_active Expired
- 1986-06-24 ES ES556551A patent/ES8707217A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES556551A0 (es) | 1987-07-16 |
| ATE40127T1 (de) | 1989-02-15 |
| EP0158340A3 (en) | 1986-05-28 |
| EP0158340B1 (en) | 1989-01-18 |
| EP0158340A2 (en) | 1985-10-16 |
| US4594342A (en) | 1986-06-10 |
| ES556552A0 (es) | 1987-12-01 |
| DE3567651D1 (en) | 1989-02-23 |
| ES8707217A1 (es) | 1987-07-16 |
| CA1218992A (en) | 1987-03-10 |
| ES8705410A1 (es) | 1987-05-01 |
| ES542126A0 (es) | 1987-05-01 |
| KR850007249A (ko) | 1985-12-02 |
| KR900005680B1 (ko) | 1990-08-06 |
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