ES8601962A1 - Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos - Google Patents
Procedimiento para la obtencion de 2-piridil-indoles n-sustituidosInfo
- Publication number
- ES8601962A1 ES8601962A1 ES530126A ES530126A ES8601962A1 ES 8601962 A1 ES8601962 A1 ES 8601962A1 ES 530126 A ES530126 A ES 530126A ES 530126 A ES530126 A ES 530126A ES 8601962 A1 ES8601962 A1 ES 8601962A1
- Authority
- ES
- Spain
- Prior art keywords
- phenylene
- alkylene
- thio
- oxy
- carboxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 N-substituted 2-pyridyl indoles Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 3
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 108010069102 Thromboxane-A synthase Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 2-PIRIDIL-INDOLES N-SUSTITUIDOS. CONSISTE EN CERRAR EL ANILLO DEL COMPUESTO DE FORMULA (II), EN PRESENCIA DE UN HIDROCARBURO HALOGENADO, COMO AGENTE DE CONDENSACION ACIDO, COMO CLORURO DE HIDROGENO ETANOLICO, O ACIDO POLIFOSFORICO, EN UN DISOLVENTE INERTE, COMO TOLUENO, O TETRAHIDROFURANO, A TEMPERATURAS ENTRE 50 Y 100C, O POR VIA TERMICA, PARA OBTENER ASI EL COMPUESTO DE FORMULA (I), SUS N-OXIDOS Y SUS SALES. SIENDO: A, ALQUILENO DE C 1 A 12, ALQUENILENO DE C 2 A 12, Y OTROS; B, CARBOXI, ALCOXI INFERIOR Y OTROS; R1, H, ALQUILO INFERIOR; R2 Y R3 JUNTOS, ATOMOS DE C ADYACENTES, Y SOLOS, ALQUILENDIOXI INFERIOR; Y AR, PIRIDILO INSISTITUIDO POR ALQUILO INFERIOR, CARBOXI, Y OTROS. SE UTILIZAN COMO INHIBIDORES DE SINTEASA DE TROMBOXANO, PARA EL TRATAMIENTO DE ENFERMEDADES CARBIOVASCULARES Y MIGRAÑA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32301881A | 1981-11-19 | 1981-11-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES530126A0 ES530126A0 (es) | 1985-11-16 |
| ES8601962A1 true ES8601962A1 (es) | 1985-11-16 |
Family
ID=23257445
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES517439A Expired ES8501755A1 (es) | 1981-11-19 | 1982-11-17 | Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos. |
| ES530127A Expired ES8608508A1 (es) | 1981-11-19 | 1984-02-28 | Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos |
| ES530128A Expired ES8602750A1 (es) | 1981-11-19 | 1984-02-28 | Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos |
| ES530126A Expired ES8601962A1 (es) | 1981-11-19 | 1984-02-28 | Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES517439A Expired ES8501755A1 (es) | 1981-11-19 | 1982-11-17 | Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos. |
| ES530127A Expired ES8608508A1 (es) | 1981-11-19 | 1984-02-28 | Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos |
| ES530128A Expired ES8602750A1 (es) | 1981-11-19 | 1984-02-28 | Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0080154B1 (es) |
| JP (1) | JPS5892677A (es) |
| KR (1) | KR880002010B1 (es) |
| AR (3) | AR241428A1 (es) |
| AT (1) | ATE15196T1 (es) |
| AU (1) | AU564233B2 (es) |
| CA (1) | CA1197249A (es) |
| DD (1) | DD204924A5 (es) |
| DE (1) | DE3265892D1 (es) |
| DK (1) | DK169104B1 (es) |
| ES (4) | ES8501755A1 (es) |
| FI (1) | FI75344C (es) |
| GB (1) | GB2111050B (es) |
| GR (1) | GR77035B (es) |
| HU (1) | HU190425B (es) |
| IE (1) | IE54156B1 (es) |
| IL (1) | IL67284A (es) |
| NO (1) | NO159929C (es) |
| NZ (1) | NZ202551A (es) |
| PH (1) | PH19212A (es) |
| PT (1) | PT75870B (es) |
| ZA (1) | ZA828505B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4511573A (en) * | 1983-05-17 | 1985-04-16 | Ciba-Geigy Corporation | 3-Substituted-2-(heteroaryl) indoles |
| GB8524157D0 (en) * | 1984-10-19 | 1985-11-06 | Ici America Inc | Heterocyclic amides |
| US4675332A (en) * | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
| US4609733A (en) * | 1984-12-27 | 1986-09-02 | Ciba-Geigy Corporation | 3-keto-substituted-N-pyridylindoles |
| GB8626296D0 (en) * | 1986-11-04 | 1986-12-03 | Ici Plc | Therapeutic agents |
| GB8626297D0 (en) * | 1986-11-04 | 1986-12-03 | Ici Plc | Pharmaceutical compositions |
| GB9319100D0 (en) * | 1993-09-15 | 1993-11-03 | Pfizer Ltd | 3-(3-pyridinyl)h-indoles |
| CA2140722A1 (en) * | 1994-01-24 | 1995-07-25 | Joseph A. Jakubowski | Beta-carboline thromboxane synthase inhibitors |
| US6828344B1 (en) * | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| GB0307891D0 (en) * | 2003-04-04 | 2003-05-14 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
| AR072297A1 (es) * | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| AU2018386201A1 (en) * | 2017-12-15 | 2020-07-30 | Bristol-Myers Squibb Company | Substituted indole ether compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3468894A (en) * | 1966-11-29 | 1969-09-23 | Geigy Chem Corp | Certain 2-pyridyl-substituted indole derivatives |
| DE2909779A1 (de) * | 1979-03-13 | 1980-09-18 | Thomae Gmbh Dr K | Neue indolderivate, deren herstellung und deren verwendung als arzneimittel |
-
1982
- 1982-11-12 GB GB08232457A patent/GB2111050B/en not_active Expired
- 1982-11-16 DE DE8282110582T patent/DE3265892D1/de not_active Expired
- 1982-11-16 AT AT82110582T patent/ATE15196T1/de active
- 1982-11-16 EP EP82110582A patent/EP0080154B1/de not_active Expired
- 1982-11-17 IL IL67284A patent/IL67284A/xx not_active IP Right Cessation
- 1982-11-17 GR GR69837A patent/GR77035B/el unknown
- 1982-11-17 CA CA000415716A patent/CA1197249A/en not_active Expired
- 1982-11-17 PH PH28151A patent/PH19212A/en unknown
- 1982-11-17 DD DD82244959A patent/DD204924A5/de not_active IP Right Cessation
- 1982-11-17 FI FI823938A patent/FI75344C/fi not_active IP Right Cessation
- 1982-11-17 ES ES517439A patent/ES8501755A1/es not_active Expired
- 1982-11-18 AU AU90675/82A patent/AU564233B2/en not_active Ceased
- 1982-11-18 IE IE2749/82A patent/IE54156B1/en not_active IP Right Cessation
- 1982-11-18 NZ NZ202551A patent/NZ202551A/xx unknown
- 1982-11-18 NO NO823869A patent/NO159929C/no unknown
- 1982-11-18 HU HU823704A patent/HU190425B/hu not_active IP Right Cessation
- 1982-11-18 PT PT75870A patent/PT75870B/pt not_active IP Right Cessation
- 1982-11-18 ZA ZA828505A patent/ZA828505B/xx unknown
- 1982-11-18 DK DK514182A patent/DK169104B1/da not_active IP Right Cessation
- 1982-11-19 JP JP57203514A patent/JPS5892677A/ja active Granted
- 1982-11-19 AR AR82291366A patent/AR241428A1/es active
- 1982-11-19 KR KR8205232A patent/KR880002010B1/ko not_active Expired
-
1984
- 1984-02-28 ES ES530127A patent/ES8608508A1/es not_active Expired
- 1984-02-28 ES ES530128A patent/ES8602750A1/es not_active Expired
- 1984-02-28 ES ES530126A patent/ES8601962A1/es not_active Expired
- 1984-11-07 AR AR84298532A patent/AR243519A1/es active
- 1984-11-07 AR AR84298531A patent/AR243177A1/es active
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted | ||
| FD1A | Patent lapsed |
Effective date: 20001102 |