ES8601975A1 - Un procedimiento para la preparacion de derivados de 1-normon-2-ilo - Google Patents
Un procedimiento para la preparacion de derivados de 1-normon-2-iloInfo
- Publication number
- ES8601975A1 ES8601975A1 ES538698A ES538698A ES8601975A1 ES 8601975 A1 ES8601975 A1 ES 8601975A1 ES 538698 A ES538698 A ES 538698A ES 538698 A ES538698 A ES 538698A ES 8601975 A1 ES8601975 A1 ES 8601975A1
- Authority
- ES
- Spain
- Prior art keywords
- normonyl
- derivatives
- processes
- substit
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 101100496169 Arabidopsis thaliana CLH1 gene Proteins 0.000 abstract 1
- 101100044057 Mesocricetus auratus SYCP3 gene Proteins 0.000 abstract 1
- 101100080600 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nse6 gene Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 101150111293 cor-1 gene Proteins 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 1-NORMON-2-ILO.UN COMPUESTO DE FORMULA (II), DONDE R1 ES ALQUILO C1-20, ALQUENILO C2-8, ARILO, ARALQUILO, HETEROCICLO (SUSTITUIDOS OPCIONALMENTE), HIDROGENO O CICLOALQUILO C3-7, Y LOS SUSTITUYENTES Z1, Z2 Y Z3 SON IGUALES O DIFERENTES, SIENDO CADA UNO DE ELLOS HIDROGENO O UN GRUPO PROTECTOR DE HIDROXILO, SE HACE REACCIONAR A BAJA TEMPERATURA (20 C A 20 C) CON FOSGENO Y UNA AMINA TERCIARIA (PREFERENTEMENTE TRIETILAMINA) Y POSTERIORMENTE CON LA ACIDA DE TETRAMETILGUANIDINIO, PARA OBTENER UN COMPUESTO DE FORMULA (I) QUE VARIA SEGUN LA NATURALEZA DEL SUSTITUYENTE R1 Y SEGUN LA CONFIGURACION Z O E DEL DOBLE ENLACE TRISUSTITUIDO. SE DESCRIBE TAMBIEN UN METODO DE OBTENCION DE OTROS COMPUESTOS DE FORMULA (I) POR MODIFICACIONES POSTERIORES DEL SUSTITUYENTE R1.SE UTILIZAN COMO FARMACOS ANTIBACTERIANOS Y ANTIMICOPLASMICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838305316A GB8305316D0 (en) | 1983-02-25 | 1983-02-25 | Compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8601975A1 true ES8601975A1 (es) | 1985-11-01 |
| ES538698A0 ES538698A0 (es) | 1985-11-01 |
Family
ID=10538629
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES530030A Expired ES8507545A1 (es) | 1983-02-25 | 1984-02-24 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo. |
| ES538698A Granted ES538698A0 (es) | 1983-02-25 | 1984-12-17 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo |
| ES538699A Expired ES8601981A1 (es) | 1983-02-25 | 1984-12-17 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo |
| ES538697A Granted ES538697A0 (es) | 1983-02-25 | 1984-12-17 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES530030A Expired ES8507545A1 (es) | 1983-02-25 | 1984-02-24 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES538699A Expired ES8601981A1 (es) | 1983-02-25 | 1984-12-17 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo |
| ES538697A Granted ES538697A0 (es) | 1983-02-25 | 1984-12-17 | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4861788A (es) |
| EP (1) | EP0123378B1 (es) |
| JP (1) | JPS59196889A (es) |
| AU (1) | AU579311B2 (es) |
| CA (1) | CA1240318A (es) |
| DE (1) | DE3479657D1 (es) |
| DK (1) | DK96184A (es) |
| ES (4) | ES8507545A1 (es) |
| GB (1) | GB8305316D0 (es) |
| GR (1) | GR79823B (es) |
| NZ (1) | NZ207261A (es) |
| ZA (1) | ZA841366B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8815626D0 (en) * | 1988-06-30 | 1988-08-03 | Beecham Group Plc | Novel compounds |
| IL94051A0 (en) * | 1989-04-12 | 1991-01-31 | Beecham Group Plc | 1-normon-2-yl-heterocycles,process for their preparation and pharmaceutical compositions containing them |
| GB8928839D0 (en) * | 1989-12-21 | 1990-02-28 | Beecham Group Plc | Novel compounds |
| GB9325832D0 (en) * | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Novel compounds |
| US6951946B2 (en) * | 2002-03-19 | 2005-10-04 | Lexicon Pharmaceuticals, Inc. | Large scale synthesis of 1,2,4- and 1,3,4-oxadiazole carboxylates |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0001914B1 (en) * | 1977-11-05 | 1981-05-20 | Beecham Group Plc | Antibacterially active amides, process for their preparation and pharmaceutical compositions containing said amides |
| EP0045150A1 (en) * | 1980-07-24 | 1982-02-03 | Beecham Group Plc | Antibacterial compounds, processes for their preparation and composititions containing them |
| PT73431B (en) * | 1980-08-02 | 1982-10-08 | Beecham Group Plc | Antibacterial compounds processes for their preparation and compositions containing them |
| US4436751A (en) * | 1980-12-31 | 1984-03-13 | Beecham Group Limited | Nitrobenzyl monates antibacterial compounds |
| IE55221B1 (en) * | 1982-02-27 | 1990-07-04 | Beecham Group Plc | Antibacterial 1-normon-2-yl-heterocyclic compounds |
-
1983
- 1983-02-25 GB GB838305316A patent/GB8305316D0/en active Pending
-
1984
- 1984-02-16 EP EP84300991A patent/EP0123378B1/en not_active Expired
- 1984-02-16 DE DE8484300991T patent/DE3479657D1/de not_active Expired
- 1984-02-23 CA CA000448133A patent/CA1240318A/en not_active Expired
- 1984-02-23 GR GR73908A patent/GR79823B/el unknown
- 1984-02-23 AU AU24860/84A patent/AU579311B2/en not_active Ceased
- 1984-02-23 NZ NZ207261A patent/NZ207261A/en unknown
- 1984-02-23 DK DK96184A patent/DK96184A/da not_active Application Discontinuation
- 1984-02-24 ES ES530030A patent/ES8507545A1/es not_active Expired
- 1984-02-24 JP JP59034093A patent/JPS59196889A/ja active Granted
- 1984-02-24 ZA ZA841366A patent/ZA841366B/xx unknown
- 1984-12-17 ES ES538698A patent/ES538698A0/es active Granted
- 1984-12-17 ES ES538699A patent/ES8601981A1/es not_active Expired
- 1984-12-17 ES ES538697A patent/ES538697A0/es active Granted
-
1987
- 1987-01-30 US US07/008,893 patent/US4861788A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4861788A (en) | 1989-08-29 |
| ES538699A0 (es) | 1985-11-01 |
| DE3479657D1 (en) | 1989-10-12 |
| ES8601980A1 (es) | 1985-11-01 |
| AU579311B2 (en) | 1988-11-24 |
| EP0123378B1 (en) | 1989-09-06 |
| EP0123378A3 (en) | 1985-09-18 |
| EP0123378A2 (en) | 1984-10-31 |
| ES538697A0 (es) | 1985-11-01 |
| JPH0534357B2 (es) | 1993-05-21 |
| ES530030A0 (es) | 1985-09-01 |
| ES8601981A1 (es) | 1985-11-01 |
| GB8305316D0 (en) | 1983-03-30 |
| DK96184A (da) | 1984-08-26 |
| ZA841366B (en) | 1985-01-30 |
| DK96184D0 (da) | 1984-02-23 |
| AU2486084A (en) | 1984-08-30 |
| NZ207261A (en) | 1987-10-30 |
| GR79823B (es) | 1984-10-31 |
| JPS59196889A (ja) | 1984-11-08 |
| CA1240318A (en) | 1988-08-09 |
| ES538698A0 (es) | 1985-11-01 |
| ES8507545A1 (es) | 1985-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19960603 |