SE8302379L - Ergolinderivat - Google Patents

Ergolinderivat

Info

Publication number: SE8302379L
Authority: SE; Sweden
Prior art keywords: group; carbon atoms; hydrogen atom; atom; phenyl
Prior art date: 1982-04-30

Application number

SE8302379A

Other languages

English (en)

Other versions

SE460967B (sv

SE8302379D0 (sv

Inventor

L Bernardi

A Temperilli

S Mantegani

G Traquandi

P Salvati

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-04-30

Filing date

1983-04-27

Publication date

1983-10-31

1983-04-27 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1983-04-27 Publication of SE8302379D0 publication Critical patent/SE8302379D0/sv

1983-10-31 Publication of SE8302379L publication Critical patent/SE8302379L/sv

1989-12-11 Publication of SE460967B publication Critical patent/SE460967B/sv

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
-1 amino, substituted amino, methyl Chemical group 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
230000001263 anti-prolactin effect Effects 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
125000004055 thiomethyl group Chemical group [H]SC([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SE8302379A 1982-04-30 1983-04-27 Ergolinderivat, saett att framstaella dessa och en farmaceutisk komposition med antihypertensiv och antiprolaktinisk verkan SE460967B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8212653		1982-04-30

Publications (3)

Publication Number	Publication Date
SE8302379D0 SE8302379D0 (sv)	1983-04-27
SE8302379L true SE8302379L (sv)	1983-10-31
SE460967B SE460967B (sv)	1989-12-11

Family

ID=10530108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8302379A SE460967B (sv)	1982-04-30	1983-04-27	Ergolinderivat, saett att framstaella dessa och en farmaceutisk komposition med antihypertensiv och antiprolaktinisk verkan

Country Status (21)

Country	Link
US (1)	US4657914A (sv)
JP (1)	JPS58194884A (sv)
AT (1)	AT385035B (sv)
AU (1)	AU553851B2 (sv)
BE (1)	BE896609A (sv)
CA (1)	CA1210389A (sv)
CH (1)	CH654305A5 (sv)
CS (1)	CS236874B2 (sv)
DE (1)	DE3314878A1 (sv)
DK (1)	DK164058C (sv)
FI (1)	FI73996C (sv)
FR (1)	FR2526022B1 (sv)
GB (1)	GB2120242A (sv)
GR (1)	GR78842B (sv)
HU (1)	HU193527B (sv)
IE (1)	IE53950B1 (sv)
IL (1)	IL68496A (sv)
IT (1)	IT1215630B (sv)
NL (1)	NL191709C (sv)
SE (1)	SE460967B (sv)
ZA (1)	ZA833008B (sv)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8714767D0 (en) *	1987-06-24	1987-07-29	Erba Farmitalia	Egoline derivatives
HU190105B (en) *	1983-06-03	1986-08-28	Gyogyszerkutato Intezet	Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
GB2173189B (en) *	1985-02-21	1988-04-27	Maruko Pharmaceutical Co	Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
GB8702364D0 (en) *	1987-02-03	1987-03-11	Erba Farmitalia	Ergolinyl heterocycles
WO2011140333A1 (en)	2010-05-07	2011-11-10	The Board Of Trustees Of The Leland Stanford Junior University	Identification of stabilizers of multimeric proteins
US20160045609A1 (en)	2014-08-14	2016-02-18	Mamoun M. Alhamadsheh	Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life
KR102874295B1 (ko)	2017-02-17	2025-10-20	에이도스 테라퓨틱스, 인코포레이티드	Ag-10, 이의 중간체, 및 이의 염을 제조하는 방법
US11058668B2 (en)	2018-03-23	2021-07-13	Eidos Therapeutics, Inc.	Methods of treating TTR amyloidosis using AG10
IL325404A (en)	2018-08-17	2026-02-01	Eidos Therapeutics Inc	Spice formulations containing 3-(3-(5,3-dimethyl-1h-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3238211A (en) *		1966-03-01		Derhvatives of g-methyl and i,g-dimethyl ergolhne
US3296071A (en) *	1963-05-31	1967-01-03	Upjohn Co	Reducing blood sugar with 3-alkyl-5-alkoxymethylisoxazole
BE712054A (sv) *	1967-03-16	1968-07-15
US3957785A (en) *	1971-12-02	1976-05-18	Societa' Farmaceutici Italia S.P.A.	Bβ-Pyrimidino-aminomethyl-10α-ergoline and 10α-methoxyergoline derivatives
CH563376A5 (sv) *	1972-06-29	1975-06-30	Lonza Ag
US3996228A (en) *	1973-12-21	1976-12-07	Societa' Farmaceutici Italia S.P.A.	Pyrimidinoaminoethyl ergoline derivatives
NL7416120A (nl) *	1973-12-21	1975-06-24	Farmaceutici Italia	Werkwijze voor het bereiden van pyrimidinoami- nomethylergolinederivaten.
US4147789A (en) *	1974-03-14	1979-04-03	Sandoz Ltd.	6-Methyl-8-thiomethyl-ergolene derivatives
IE41533B1 (en) *	1974-03-14	1980-01-30	Sandoz Ltd	Thiomethyl ergolene derivatives
CS171480B1 (sv) *	1974-03-19	1976-10-29
CS177530B1 (en) *	1974-07-19	1977-07-29	Miroslav Semonsky	New nbeta-substituted derivatives of b-beta-aminoethyl-ergoline-i their salts and methods for the production thereof
CH617452A5 (sv) *	1974-10-25	1980-05-30	Hoffmann La Roche
CH615929A5 (en) *	1975-06-02	1980-02-29	Sandoz Ag	Process for the preparation of novel ergoline compounds
CH622518A5 (en) *	1976-12-14	1981-04-15	Sandoz Ag	Process for the preparation of novel ergoline compounds
AU526764B2 (en) *	1978-09-08	1983-01-27	Farmitalia Carlo Erba S.P.A.	Ergoline derivatives
GB2056437A (en) *	1979-08-07	1981-03-18	Erba Farmitalia	Secoergoline derivatives
US4382940A (en) *	1979-12-06	1983-05-10	Farmitalia Carlo Erba S.P.A.	Ercoline derivatives and therapeutic compositions having CNS affecting activity

1983
- 1983-04-21 GB GB08310843A patent/GB2120242A/en not_active Withdrawn
- 1983-04-25 FI FI831406A patent/FI73996C/sv not_active IP Right Cessation
- 1983-04-25 GR GR71190A patent/GR78842B/el unknown
- 1983-04-25 IE IE932/83A patent/IE53950B1/en not_active IP Right Cessation
- 1983-04-25 US US06/488,168 patent/US4657914A/en not_active Expired - Fee Related
- 1983-04-25 CS CS832921A patent/CS236874B2/cs unknown
- 1983-04-25 DE DE19833314878 patent/DE3314878A1/de active Granted
- 1983-04-26 JP JP58072295A patent/JPS58194884A/ja active Granted
- 1983-04-26 CH CH2256/83A patent/CH654305A5/it not_active IP Right Cessation
- 1983-04-26 IL IL68496A patent/IL68496A/xx not_active IP Right Cessation
- 1983-04-27 CA CA000426874A patent/CA1210389A/en not_active Expired
- 1983-04-27 SE SE8302379A patent/SE460967B/sv not_active IP Right Cessation
- 1983-04-27 HU HU851631A patent/HU193527B/hu not_active IP Right Cessation
- 1983-04-27 FR FR8306926A patent/FR2526022B1/fr not_active Expired
- 1983-04-27 IT IT8320807A patent/IT1215630B/it active
- 1983-04-28 DK DK189983A patent/DK164058C/da not_active IP Right Cessation
- 1983-04-28 AU AU14029/83A patent/AU553851B2/en not_active Ceased
- 1983-04-28 ZA ZA833008A patent/ZA833008B/xx unknown
- 1983-04-29 NL NL8301529A patent/NL191709C/xx not_active IP Right Cessation
- 1983-04-29 BE BE0/210660A patent/BE896609A/fr not_active IP Right Cessation
- 1983-04-29 AT AT0156783A patent/AT385035B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE3314878A1 (de)	1983-11-03
GB2120242A (en)	1983-11-30
DK164058B (da)	1992-05-04
DK164058C (da)	1992-10-12
IT8320807A0 (it)	1983-04-27
JPH0354668B2 (sv)	1991-08-20
GB8310843D0 (en)	1983-05-25
CA1210389A (en)	1986-08-26
HU193527B (en)	1987-10-28
ZA833008B (en)	1984-01-25
FI831406L (fi)	1983-10-31
NL8301529A (nl)	1983-11-16
NL191709C (nl)	1996-04-02
CH654305A5 (it)	1986-02-14
ATA156783A (de)	1987-07-15
IE830932L (en)	1983-10-30
FI73996C (sv)	1987-12-10
NL191709B (nl)	1995-12-01
DK189983A (da)	1983-10-31
GR78842B (sv)	1984-10-02
FR2526022B1 (fr)	1985-06-14
CS236874B2 (en)	1985-05-15
IL68496A0 (en)	1983-07-31
BE896609A (fr)	1983-08-16
FR2526022A1 (fr)	1983-11-04
IT1215630B (it)	1990-02-22
DK189983D0 (da)	1983-04-28
IL68496A (en)	1985-06-30
AT385035B (de)	1988-02-10
AU553851B2 (en)	1986-07-31
FI73996B (fi)	1987-08-31
SE460967B (sv)	1989-12-11
DE3314878C2 (sv)	1993-09-23
US4657914A (en)	1987-04-14
JPS58194884A (ja)	1983-11-12
AU1402983A (en)	1983-11-03
IE53950B1 (en)	1989-04-26
SE8302379D0 (sv)	1983-04-27
FI831406A0 (fi)	1983-04-25

Legal Events

Date

Code

Title

Description

1995-01-31

NAL

Patent in force

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1999-01-18

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