ES8602003A1 - Procedimiento de preparacion de derivados de 1,3,4,9-tetra- hidropirano(3,4,b)indol - Google Patents

Procedimiento de preparacion de derivados de 1,3,4,9-tetra- hidropirano(3,4,b)indol

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Publication number
ES8602003A1
ES8602003A1 ES540920A ES540920A ES8602003A1 ES 8602003 A1 ES8602003 A1 ES 8602003A1 ES 540920 A ES540920 A ES 540920A ES 540920 A ES540920 A ES 540920A ES 8602003 A1 ES8602003 A1 ES 8602003A1
Authority
ES
Spain
Prior art keywords
solvent
pyrano
prepn
hydro
tetra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540920A
Other languages
English (en)
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ES540920A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fordonal SA
Original Assignee
Fordonal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fordonal SA filed Critical Fordonal SA
Priority to ES540920A priority Critical patent/ES8602003A1/es
Publication of ES540920A0 publication Critical patent/ES540920A0/es
Publication of ES8602003A1 publication Critical patent/ES8602003A1/es
Expired legal-status Critical Current

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Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE 1,3,4,9-TETRAHIDROPIRANO3,4,BINDOL. CONSISTE EN HACER REACCIONAR UN DERIVADO DE INDOL DE FORMULA (II) CON UN NITRILO DE FORMULA (III), EFECTUANDOSE ESTA REACCION EN EL SENO DE UN DISOLVENTE COMO TOLUENO, BENCENO O XILENO, EN PRESENCIA DE UN ACIDO COMO BENCENOSULFONICO O TOLUENOSULFONICO, PARA FORMAR EL COMPUESTO INTERMEDIO DE FORMULA (IV), QUE SE SOMETE A UNA HIDROLISIS POSTERIOR UTILIZANDO COMO DISOLVENTE UNA MEZCLA DE AGUA Y DIOXANO O TETRAHIDROFURANO, A LA TEMPERATURA DE EBULLICION Y EN PRESENCIA DE UN ACIDO COMO SULFURICO O FOSFORICO, PARA FORMAR EL DERIVADO DE 1,3,4,9-TETRAHIDROPIRANO3,4,BINDOL DE FORMULA (I) QUE SE AISLA POR DESTILACION DEL DISOLVENTE ORGANICO Y FILTRACION DE LA SUSPENSION ACUOSA RESULTANTE, PURIFICANDOSE POR CRISTALIZACION EN UN DISOLVENTE. TIENEN UTILIDAD TERAPEUTICA POR SU ACTIVIDAD ANTIINFLAMATORIA.
ES540920A 1985-03-05 1985-03-05 Procedimiento de preparacion de derivados de 1,3,4,9-tetra- hidropirano(3,4,b)indol Expired ES8602003A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES540920A ES8602003A1 (es) 1985-03-05 1985-03-05 Procedimiento de preparacion de derivados de 1,3,4,9-tetra- hidropirano(3,4,b)indol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES540920A ES8602003A1 (es) 1985-03-05 1985-03-05 Procedimiento de preparacion de derivados de 1,3,4,9-tetra- hidropirano(3,4,b)indol

Publications (2)

Publication Number Publication Date
ES540920A0 ES540920A0 (es) 1985-11-16
ES8602003A1 true ES8602003A1 (es) 1985-11-16

Family

ID=8488790

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540920A Expired ES8602003A1 (es) 1985-03-05 1985-03-05 Procedimiento de preparacion de derivados de 1,3,4,9-tetra- hidropirano(3,4,b)indol

Country Status (1)

Country Link
ES (1) ES8602003A1 (es)

Also Published As

Publication number Publication date
ES540920A0 (es) 1985-11-16

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PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20050718