ES8602008A1 - Un procedimiento para preparar nuevas benzotiopiranpiridinonas - Google Patents
Un procedimiento para preparar nuevas benzotiopiranpiridinonasInfo
- Publication number
- ES8602008A1 ES8602008A1 ES539317A ES539317A ES8602008A1 ES 8602008 A1 ES8602008 A1 ES 8602008A1 ES 539317 A ES539317 A ES 539317A ES 539317 A ES539317 A ES 539317A ES 8602008 A1 ES8602008 A1 ES 8602008A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- branched
- opt
- radical
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 5
- FYPPYPNWPSFUMG-UHFFFAOYSA-N 10h-thiochromeno[3,2-b]pyridine 5-oxide Chemical class C1=CC=C2S(=O)C3=CC=CC=C3CC2=N1 FYPPYPNWPSFUMG-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 14
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 9
- 125000005843 halogen group Chemical group 0.000 abstract 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 5
- -1 nitro, amino Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004442 acylamino group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000000532 dioxanyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 208000019901 Anxiety disease Diseases 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N Dopamine Natural products NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
- 230000001430 anti-depressive effect Effects 0.000 abstract 2
- 230000001090 anti-dopaminergic effect Effects 0.000 abstract 2
- 230000000561 anti-psychotic effect Effects 0.000 abstract 2
- 239000000935 antidepressant agent Substances 0.000 abstract 2
- 229940005513 antidepressants Drugs 0.000 abstract 2
- 230000036506 anxiety Effects 0.000 abstract 2
- 230000003542 behavioural effect Effects 0.000 abstract 2
- 229960003638 dopamine Drugs 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000003551 muscarinic effect Effects 0.000 abstract 2
- 210000000653 nervous system Anatomy 0.000 abstract 2
- 239000002464 receptor antagonist Substances 0.000 abstract 2
- 229940044551 receptor antagonist Drugs 0.000 abstract 2
- 230000009291 secondary effect Effects 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 abstract 1
- 125000004755 (C2-C7) acylamino group Chemical group 0.000 abstract 1
- KKFDJZZADQONDE-UHFFFAOYSA-N (hydridonitrato)hydroxidocarbon(.) Chemical compound O[C]=N KKFDJZZADQONDE-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical compound N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical compound O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 abstract 1
- 229920000137 polyphosphoric acid Polymers 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Common Detailed Techniques For Electron Tubes Or Discharge Tubes (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR NUEVAS BENZOTIOPIRANPIRIDINONAS. CONSISTE EN HACER REACCIONAR UN PRODUCTO DE FORMULA (II) CON UN DERIVADO HALOGENADO DE FORMULA (III) EN CALIENTE, EN EL SENO DE UNA BASE AMINICA TAL COMO DIMETILFORMAMIDA, Y EN PRESENCIA DE YODURO DE POTASIO Y DE UN CARBONATO ALCALINO, TAL COMO CARBONATO DE POTASIO Y DURANTE VARIAS HORAS A VARIOS DIAS, PARA OBTENER UN PRODUCTO DE FORMULA (I) Y SUS SALES. SIENDO A, B, C Y D, IDENTICOS O DIFERENTES, H UN RADICAL ALQUILO LINEAL O RAMIFICADO DE C 1 A 5, UN RADICAL ALCOXILO LINEAL O RAMIFICADO DE C 1 A 6 Y OTROS; HAL, CL, BR, I; R1, H; R,, UN RADICAL ALQUILO, LINEAL O RAMIFICADO DE C 1 A 9, O ALQUENILO, LINEAL O RAMIFICADO DE C 2 A 9; N UN NUMERO ENTERO ENTRE 1 Y 4 Y Z UN RADICAL CICLOALQUILO O CICLOALQUENILO DE C 3 A 9, UN RADICAL DIOXANILO Y OTROS. SE UTILIZA COMO ANTIDOPAMINERGICAS, ANTIDEPRESIVOS Y ANTISICOTICAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8220433 | 1982-07-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8602008A1 true ES8602008A1 (es) | 1985-11-01 |
| ES539317A0 ES539317A0 (es) | 1985-11-01 |
Family
ID=10531672
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES524090A Expired ES8504811A1 (es) | 1982-07-14 | 1983-07-13 | Un procedimiento para preparar nuevas benzotiopiridinonas |
| ES539317A Granted ES539317A0 (es) | 1982-07-14 | 1985-01-02 | Un procedimiento para preparar nuevas benzotiopiranpiridinonas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES524090A Expired ES8504811A1 (es) | 1982-07-14 | 1983-07-13 | Un procedimiento para preparar nuevas benzotiopiridinonas |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4547507A (es) |
| EP (1) | EP0099303B1 (es) |
| JP (1) | JPS5946286A (es) |
| KR (1) | KR900006755B1 (es) |
| AT (1) | ATE29030T1 (es) |
| AU (1) | AU559672B2 (es) |
| CA (1) | CA1202974A (es) |
| DE (1) | DE3373097D1 (es) |
| DK (1) | DK322383A (es) |
| ES (2) | ES8504811A1 (es) |
| FI (1) | FI75162C (es) |
| GB (1) | GB2123419B (es) |
| GR (1) | GR79605B (es) |
| HU (1) | HU188475B (es) |
| IE (1) | IE55315B1 (es) |
| IL (1) | IL69132A (es) |
| NZ (1) | NZ204893A (es) |
| PT (1) | PT77021B (es) |
| ZA (1) | ZA834868B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4689225A (en) * | 1984-11-02 | 1987-08-25 | Institut Merieux | Vaccine for cytomegalovirus |
| US5198598A (en) * | 1991-07-19 | 1993-03-30 | Henkel Kommanditgesellschaft Auf Aktien | Telomerization process of a conjugated alkadiene with a polyol |
| GB9418326D0 (en) * | 1994-09-12 | 1994-11-02 | Lilly Industries Ltd | Pharmaceutical compounds |
| ATE247114T1 (de) * | 1994-09-12 | 2003-08-15 | Lilly Co Eli | Serotonergische modulatoren |
| US5574028A (en) * | 1994-10-31 | 1996-11-12 | Eli Lilly And Company | Method for treating anxiety |
| GB2308362A (en) * | 1995-12-19 | 1997-06-25 | Lilly Industries Ltd | Pharmaceutical indole derivatives |
| RU2326870C2 (ru) * | 2003-08-04 | 2008-06-20 | Валерий Хажмуратович ЖИЛОВ | Применение циклических биоизостеров производных пуриновой системы для лечения расстройств, вызванных нарушениями нитрергической и дофаминергической систем |
| WO2005012309A1 (fr) * | 2003-08-04 | 2005-02-10 | Valery Khazhmuratovich Zhilov | Bioisosteres cycliques issus d'un systeme purine et composition pharmaceutique a base desdits bioisosteres |
| EP3375784A1 (en) * | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aza-dihydro-acridone derivatives |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3086972A (en) * | 1960-03-24 | 1963-04-23 | Sandoz Ag | Aza-thiaxanthene derivatives |
| US3236854A (en) * | 1961-09-08 | 1966-02-22 | Rhone Poulenc Sa | Azathioxanthene derivatives |
| CH500215A (de) * | 1967-12-01 | 1970-12-15 | Sandoz Ag | Verfahren zur Herstellung neuer Benzothiopyranopyridinderivate |
| EP0035924B1 (fr) * | 1980-03-06 | 1983-08-03 | Roussel-Uclaf | Nouvelles benzothiopyrano/2,3-c/pyridines et leurs sels avec les acides, leur préparation, leur application à titre de médicaments et les compositions les renfermant |
-
1983
- 1983-06-30 IL IL69132A patent/IL69132A/xx unknown
- 1983-07-04 ZA ZA834868A patent/ZA834868B/xx unknown
- 1983-07-11 DE DE8383401431T patent/DE3373097D1/de not_active Expired
- 1983-07-11 AT AT83401431T patent/ATE29030T1/de not_active IP Right Cessation
- 1983-07-11 EP EP83401431A patent/EP0099303B1/fr not_active Expired
- 1983-07-12 US US06/512,964 patent/US4547507A/en not_active Expired - Fee Related
- 1983-07-12 PT PT77021A patent/PT77021B/pt not_active IP Right Cessation
- 1983-07-12 GR GR71913A patent/GR79605B/el unknown
- 1983-07-13 CA CA000432346A patent/CA1202974A/fr not_active Expired
- 1983-07-13 DK DK322383A patent/DK322383A/da not_active Application Discontinuation
- 1983-07-13 FI FI832560A patent/FI75162C/fi not_active IP Right Cessation
- 1983-07-13 HU HU832497A patent/HU188475B/hu not_active IP Right Cessation
- 1983-07-13 ES ES524090A patent/ES8504811A1/es not_active Expired
- 1983-07-13 AU AU16781/83A patent/AU559672B2/en not_active Ceased
- 1983-07-13 NZ NZ204893A patent/NZ204893A/en unknown
- 1983-07-13 IE IE1623/83A patent/IE55315B1/en not_active IP Right Cessation
- 1983-07-13 GB GB08318911A patent/GB2123419B/en not_active Expired
- 1983-07-14 KR KR1019830003209A patent/KR900006755B1/ko not_active Expired
- 1983-07-14 JP JP58127064A patent/JPS5946286A/ja active Pending
-
1985
- 1985-01-02 ES ES539317A patent/ES539317A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FI75162B (fi) | 1988-01-29 |
| IL69132A (en) | 1986-02-28 |
| IE831623L (en) | 1984-01-14 |
| DK322383A (da) | 1984-01-15 |
| DK322383D0 (da) | 1983-07-13 |
| DE3373097D1 (en) | 1987-09-24 |
| IE55315B1 (en) | 1990-08-01 |
| PT77021B (fr) | 1986-04-11 |
| ES524090A0 (es) | 1985-04-16 |
| ZA834868B (en) | 1984-08-29 |
| EP0099303A2 (fr) | 1984-01-25 |
| GB8318911D0 (en) | 1983-08-17 |
| AU1678183A (en) | 1984-01-19 |
| FI832560L (fi) | 1984-01-15 |
| ES8504811A1 (es) | 1985-04-16 |
| GR79605B (es) | 1984-10-31 |
| EP0099303A3 (en) | 1984-09-12 |
| IL69132A0 (en) | 1983-10-31 |
| KR900006755B1 (ko) | 1990-09-20 |
| CA1202974A (fr) | 1986-04-08 |
| NZ204893A (en) | 1986-07-11 |
| AU559672B2 (en) | 1987-03-19 |
| ATE29030T1 (de) | 1987-09-15 |
| FI832560A0 (fi) | 1983-07-13 |
| FI75162C (fi) | 1988-05-09 |
| EP0099303B1 (fr) | 1987-08-19 |
| KR840005449A (ko) | 1984-11-12 |
| GB2123419B (en) | 1985-10-02 |
| HU188475B (en) | 1986-04-28 |
| ES539317A0 (es) | 1985-11-01 |
| GB2123419A (en) | 1984-02-01 |
| US4547507A (en) | 1985-10-15 |
| PT77021A (fr) | 1983-08-01 |
| JPS5946286A (ja) | 1984-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |