ES8602010A1 - Un procedimiento para preparar 1, 2, 3-triazino-(4', 5' : 4 ; 5) tieno (2, 3-b)-quinolin-4 (3h)-onas. - Google Patents

Un procedimiento para preparar 1, 2, 3-triazino-(4', 5' : 4 ; 5) tieno (2, 3-b)-quinolin-4 (3h)-onas.

Info

Publication number
ES8602010A1
ES8602010A1 ES532698A ES532698A ES8602010A1 ES 8602010 A1 ES8602010 A1 ES 8602010A1 ES 532698 A ES532698 A ES 532698A ES 532698 A ES532698 A ES 532698A ES 8602010 A1 ES8602010 A1 ES 8602010A1
Authority
ES
Spain
Prior art keywords
triazino
thieno
quinoline
ones
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532698A
Other languages
English (en)
Other versions
ES532698A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of ES8602010A1 publication Critical patent/ES8602010A1/es
Publication of ES532698A0 publication Critical patent/ES532698A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 1,2,3-TRIAZINO-(4,5,4,5)TIENO(2,3-B)-QUINOLIN-4 (3H)-ONAS. COMPRENDE: A) HACER REACCIONAR A (A) CON HIDROCLORURO DE HIDROXILAMINA, PARA DAR LA OXIMA DE (A); B) DESHIDRATAR LA OXIMA DE (A) CON ANHIDRIDO ACETICO PARA CONSEGUIR (B); C) HACER REACCIONAR A (B) CON 2-MERCAPTOACETAMIDA EN CONDICIONES ALCALINAS, PARA PRODUCIR LA AMINOCARBOXAMIDA DE FORMULA (II); D) HACER REACCIONAR A (II) CON NITRITO SODICO EN ACIDO ACETICO, PARA REALIZAR EL COMPUESTO DE FORMULA (I) SIENDO (R-H); Y E) TRATAR A (I) CON UNA BASE Y UN BROMURO O YODURO DE ALQUILO, PARA OBTENER A (I) (R ALQUILO DE C 1 A 4). SIENDO (A) 2-CLORO-3-QUINOLINCARBOXALDEHIDO; (B) 2-CLORO-3-QUINOLINCARBONITRILO Y R, Y R,, O METOXI. SE UTILIZAN COMO ANTIALERGICOS.
ES532698A 1983-05-23 1984-05-22 Un procedimiento para preparar 1, 2, 3-triazino-(4', 5' : 4 ; 5) tieno (2, 3-b)-quinolin-4 (3h)-onas. Granted ES532698A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/496,800 US4496725A (en) 1983-05-23 1983-05-23 Substituted 1,2,3-triazino[4',5':4,5]-thieno[2,3-B]quinolin-4(3H)-ones

Publications (2)

Publication Number Publication Date
ES8602010A1 true ES8602010A1 (es) 1985-11-01
ES532698A0 ES532698A0 (es) 1985-11-01

Family

ID=23974193

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532698A Granted ES532698A0 (es) 1983-05-23 1984-05-22 Un procedimiento para preparar 1, 2, 3-triazino-(4', 5' : 4 ; 5) tieno (2, 3-b)-quinolin-4 (3h)-onas.

Country Status (19)

Country Link
US (1) US4496725A (es)
EP (1) EP0126487B1 (es)
JP (1) JPS59222493A (es)
KR (1) KR900002248B1 (es)
AT (1) ATE36713T1 (es)
AU (1) AU558765B2 (es)
CA (1) CA1227484A (es)
DE (1) DE3473601D1 (es)
DK (1) DK251284A (es)
ES (1) ES532698A0 (es)
GR (1) GR82028B (es)
HU (1) HU189898B (es)
IE (1) IE57490B1 (es)
IL (1) IL71881A (es)
NO (1) NO842026L (es)
NZ (1) NZ208205A (es)
PH (1) PH19387A (es)
PT (1) PT78624B (es)
ZA (1) ZA843794B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581448A (en) * 1984-10-10 1986-04-08 Merrell Dow Pharmaceuticals Inc. Thienotriazines
DE4014171A1 (de) * 1990-05-03 1991-11-07 Basf Ag Cyanochinolinverbindungen
US6332287B1 (en) 1997-03-06 2001-12-25 Carroll M. Geraldson Plant cultivation apparatus and method
CN102757447B (zh) * 2011-07-05 2014-12-31 北京大学 一种尿素通道蛋白抑制剂及其制备方法与应用
US9493481B2 (en) 2012-02-23 2016-11-15 Vanderbilt University Substituted 5-aminothieno[2,3—C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
US9637498B2 (en) 2013-08-23 2017-05-02 Vanderbilt University Substituted thieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239887A (en) * 1979-10-31 1980-12-16 Usv Pharmaceutical Corporation Pyridothienotriazines

Also Published As

Publication number Publication date
EP0126487B1 (en) 1988-08-24
PT78624A (en) 1984-06-01
CA1227484A (en) 1987-09-29
DK251284D0 (da) 1984-05-22
NZ208205A (en) 1986-08-08
NO842026L (no) 1984-11-26
US4496725A (en) 1985-01-29
PH19387A (en) 1986-04-07
KR900002248B1 (ko) 1990-04-07
JPS59222493A (ja) 1984-12-14
AU2844784A (en) 1984-11-29
ZA843794B (en) 1984-12-24
KR840009311A (ko) 1984-12-26
EP0126487A3 (en) 1985-07-31
AU558765B2 (en) 1987-02-05
PT78624B (en) 1986-06-18
IE841254L (en) 1984-11-23
DE3473601D1 (en) 1988-09-29
HU189898B (en) 1986-08-28
GR82028B (es) 1984-12-12
IL71881A0 (en) 1984-09-30
IE57490B1 (en) 1992-10-07
ATE36713T1 (de) 1988-09-15
IL71881A (en) 1987-07-31
HUT34199A (en) 1985-02-28
ES532698A0 (es) 1985-11-01
DK251284A (da) 1984-11-24
EP0126487A2 (en) 1984-11-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519