ES8602017A1 - Procedimiento para la preparacion de acidos 7-substituidos amino-desacetoxicefalosporanicos y sus esteres - Google Patents
Procedimiento para la preparacion de acidos 7-substituidos amino-desacetoxicefalosporanicos y sus esteresInfo
- Publication number
- ES8602017A1 ES8602017A1 ES534646A ES534646A ES8602017A1 ES 8602017 A1 ES8602017 A1 ES 8602017A1 ES 534646 A ES534646 A ES 534646A ES 534646 A ES534646 A ES 534646A ES 8602017 A1 ES8602017 A1 ES 8602017A1
- Authority
- ES
- Spain
- Prior art keywords
- substd
- cpd
- opt
- prodn
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- RCCPEORTSYDPMB-UHFFFAOYSA-N hydroxy benzenecarboximidothioate Chemical compound OSC(=N)C1=CC=CC=C1 RCCPEORTSYDPMB-UHFFFAOYSA-N 0.000 title 1
- 229940049954 penicillin Drugs 0.000 title 1
- -1 silylsulphamoyl Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- NLZHNYNXJJFHRW-ZCFIWIBFSA-N (6r)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)C[C@H]21 NLZHNYNXJJFHRW-ZCFIWIBFSA-N 0.000 abstract 1
- FZEVMBJWXHDLDB-ZCFIWIBFSA-N (6r)-5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one Chemical group S1CC=CN2C(=O)C[C@H]21 FZEVMBJWXHDLDB-ZCFIWIBFSA-N 0.000 abstract 1
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 1
- GJTUPTFBMJUOAW-UHFFFAOYSA-N [SiH3]NS(=O)(=O)N Chemical compound [SiH3]NS(=O)(=O)N GJTUPTFBMJUOAW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005103 alkyl silyl group Chemical group 0.000 abstract 1
- 125000003460 beta-lactamyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000002632 imidazolidinyl group Chemical group 0.000 abstract 1
- 125000001261 isocyanato group Chemical group *N=C=O 0.000 abstract 1
- 125000000160 oxazolidinyl group Chemical group 0.000 abstract 1
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 abstract 1
- 125000005544 phthalimido group Chemical group 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE ACIDOS 7-SUSTITUIDOS AMINODESACETOXICEFALOSPERANICOS Y SUS ESTERES. CONSISTENTE EN LA CICLACION DE UN COMPUESTO DERIVADO DE AZETIDINA DE FORMULA (I) EN PRESENCIA DE UN HIDROBROMURO DE UN ACIDO PIRIDIN O DIACINCARBOXILICO PARA OBTENER UNA CEFALOSPORINA CON HETEROBICICLO 3-CEFEM DE FORMULA (II). EL COMPUESTO DE FORMULA (I) SE OBTIENE CALENTANDO UNA PENICILINA -(5)- OXIDO DE FORMULA (III) A TEMPERATURAS COMPRENDIDAS ENTRE 70 Y 130C CON UN AGENTE SILILANTE, PREFERENTEMENTE LA N, N-BIS TRIMETILSILILSUFAMIDA, O N,N-BIS-TRINDILSILILUREA.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES534646A ES8602017A1 (es) | 1984-07-27 | 1984-07-27 | Procedimiento para la preparacion de acidos 7-substituidos amino-desacetoxicefalosporanicos y sus esteres |
| US06/752,897 US4767851A (en) | 1984-07-16 | 1985-07-08 | Process for the preparation of 7-amino and 7-substituted amino-desacetoxycephalosporins |
| DE8585401458T DE3578070D1 (de) | 1984-07-16 | 1985-07-16 | Verfahren zur herstellung von 7-amino- oder 7-substituierten aminodesacetoxycephalosporinen aus den uebereinstimmenden 6-substituierten aminopenicillinsulphoxyden. |
| EP85401458A EP0169144B1 (en) | 1984-07-16 | 1985-07-16 | Process for the preparation of 7-amino and 7-substituted amino-desacetoxycephalosporins from the corresponding 6-substituted amino penicillin sulphoxides |
| AT85401458T ATE53392T1 (de) | 1984-07-16 | 1985-07-16 | Verfahren zur herstellung von 7-amino- oder 7substituierten aminodesacetoxycephalosporinen aus den uebereinstimmenden 6-substituierten aminopenicillinsulphoxyden. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES534646A ES8602017A1 (es) | 1984-07-27 | 1984-07-27 | Procedimiento para la preparacion de acidos 7-substituidos amino-desacetoxicefalosporanicos y sus esteres |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES534646A0 ES534646A0 (es) | 1985-12-01 |
| ES8602017A1 true ES8602017A1 (es) | 1985-12-01 |
Family
ID=8487692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES534646A Expired ES8602017A1 (es) | 1984-07-16 | 1984-07-27 | Procedimiento para la preparacion de acidos 7-substituidos amino-desacetoxicefalosporanicos y sus esteres |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES8602017A1 (es) |
-
1984
- 1984-07-27 ES ES534646A patent/ES8602017A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES534646A0 (es) | 1985-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1163924A (en) | DERIVATIVES OF 6.beta.-HYDROXYALKYLPENICILLANIC ACIDS AS .beta.-LACTAMASE INHIBITORS | |
| MY104861A (en) | Bis-aza-bicyclic anxiolytic agents. | |
| GB1147760A (en) | Heterocyclic nitrogen compounds | |
| ATE34985T1 (de) | 1,7-diamino-1,4-dihydro-4-oxo-3-(aza) chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung bakterieller erkrankungen. | |
| MY117265A (en) | 6-(substituted methylene) penems and intermediates | |
| ES8602015A1 (es) | Procedimiento de preparacion de acidos 7-substituido amino-desacetoxicefalosporanicos | |
| SE7713901L (sv) | Tiooximcefalosporin- och penicillin-derivat | |
| ES449141A1 (es) | Procedimiento para la obtencion de penicilinas. | |
| US3635953A (en) | 2-amidopenicillins and methods for their preparation | |
| KR880000490B1 (en) | 1-oxa-l-dethia-cephalosporin compounds and antibacterial agent comprising the same | |
| FR2248277A1 (en) | Desacetoxy cephalosporins prepn. - by redn. with titanous salt and treatment with tert. nitrogen base | |
| PT81446A (en) | Cephalosporin antibiotics | |
| ES459655A1 (es) | Procedimiento para la obtencion de compuestos cefem. | |
| IT1198288B (it) | Procedimento per la preparazione di composti ad attivita' anti ulcera | |
| IT1204495B (it) | Procedimento di sintesi per l'ottenimento di molecole aventi attivita' farmacologica via uree mono e bisostiuite | |
| FR2191887A1 (en) | 7-Substd 5-hydroxy-imidazo pyrimidines - antiinflammatories, and immuno-suppressives, from 2-aminoimidazoline and substd ethyl acetates | |
| GB1449398A (en) | Substituted acetamidocephalosporins | |
| FR2449086A1 (fr) | Nouveaux 2-(2,2-dihalovinyl) thiophenes | |
| FI872797A7 (fi) | Substituerade kinoxalindioner och kinolindioner. | |
| ES2002912A6 (es) | Procedimiento para la produccion de antibioticos de cefalosporina | |
| ATE24513T1 (de) | Verfahren zur herstellung von 6-(aminomethyl)penicillans|ure-1,1-dioxyd und derivaten davon. | |
| NL7412848A (en) | Alpha-aminopenicillin and cephalosporin prepn - by acylating 7-amino (desacetoxy)cephalosporanic or 6-aminopenicillanic acid | |
| ES427389A1 (es) | Un procedimiento para escindir la funcion del acido amico. | |
| ES8607316A1 (es) | Un procedimiento para la preparacion de un compuesto de b- lactama | |
| ES2009145A6 (es) | Procedimiento para la obtencion e 2-amino derivados de 3,4-dihidor-4oxo-pirido (2,3d) pirimidinas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19711001 |