ES8603902A1 - Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos - Google Patents

Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos

Info

Publication number
ES8603902A1
ES8603902A1 ES537717A ES537717A ES8603902A1 ES 8603902 A1 ES8603902 A1 ES 8603902A1 ES 537717 A ES537717 A ES 537717A ES 537717 A ES537717 A ES 537717A ES 8603902 A1 ES8603902 A1 ES 8603902A1
Authority
ES
Spain
Prior art keywords
substd
opt
alkyl
dihydropyridine
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537717A
Other languages
English (en)
Other versions
ES537717A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of ES537717A0 publication Critical patent/ES537717A0/es
Publication of ES8603902A1 publication Critical patent/ES8603902A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

METODO DE FABRICAR 1,4-DIHIDROPIRIDINA-3-CARBOXILATOS. COMPRENDE: A) SOMETER A CONDENSACION DESHIDRATANTE UN DERIVADO DE BENZALDEHIDICO DE FORMULA (II) EN UN DISOLVENTE ORGANICO, CON UN COMPUESTO DE FORMULA (III) PARA DAR UN COMPUESTO DE FORMULA (IV); Y B) HACER REACCIONAR EL COMPUESTO (IV), DISUELTO EN UN COMPUESTO ORGANICO, CON UN ENAMINOESTER DE UN COMPUESTO DE FORMULA (V) PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO; R1 Y R2 HIDROGENO, RESTO HIDROGENADO CON C 1 A 10, COMPUESTO POR UNA O VARIAS CADENAS, UNO O VARIOS ANILLOS Y CON 0 A 4 ENLACES INSATURADOS; R3 Y R5 UN GRUPO ALQUILO INFERIOR; R4 HIDROGENO, TETRAHIDROFURFURILO OPCIONALMENTE SUSTITUIDO CON ALQUILO Y OTROS; Y R6 Y R7 HIDROGENO, GRUPOS NITRO Y OTROS. SON UTILES POR SU ACCION VASODILATADORA Y REDUCTORA DE LA PRESION SANGUINEA.
ES537717A 1983-03-04 1984-11-16 Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos Expired ES8603902A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58036211A JPS59161392A (ja) 1983-03-04 1983-03-04 ジヒドロピリジン誘導体及びその製法

Publications (2)

Publication Number Publication Date
ES537717A0 ES537717A0 (es) 1986-01-01
ES8603902A1 true ES8603902A1 (es) 1986-01-01

Family

ID=12463415

Family Applications (2)

Application Number Title Priority Date Filing Date
ES530248A Expired ES8505379A1 (es) 1983-03-04 1984-03-02 Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos
ES537717A Expired ES8603902A1 (es) 1983-03-04 1984-11-16 Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES530248A Expired ES8505379A1 (es) 1983-03-04 1984-03-02 Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos

Country Status (8)

Country Link
US (1) US4535073A (es)
EP (1) EP0121117B1 (es)
JP (1) JPS59161392A (es)
KR (1) KR840007882A (es)
CA (1) CA1254206A (es)
DE (1) DE3479582D1 (es)
ES (2) ES8505379A1 (es)
GB (1) GB2140015B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0141221A1 (en) * 1983-09-26 1985-05-15 Nissan Chemical Industries Ltd. 1,4-Dihydropyridine-5-phosphonic acid ester
JPS6130591A (ja) * 1984-07-20 1986-02-12 Nissan Chem Ind Ltd ジヒドロピリジン−５−ホスホネ−ト誘導体
EP0141222B1 (en) * 1983-09-26 1989-04-12 Nissan Chemical Industries Ltd. Dihydropyridine-5-phosphonic acid cyclic ester
JPS6069089A (ja) * 1983-09-26 1985-04-19 Nissan Chem Ind Ltd ジヒドロピリジン−５−ホスホネ−ト誘導体およびその製造法
JPS60248693A (ja) * 1984-04-19 1985-12-09 Nippon Shinyaku Co Ltd ピリジン誘導体及び製法
JPS6127995A (ja) * 1984-07-18 1986-02-07 Nissan Chem Ind Ltd ジヒドロピリジン−５−ホスホン酸モノエステル誘導体およびその製造法
IT1201444B (it) * 1985-08-01 1989-02-02 Boehringer Biochemia Srl Fosfonopiridine a loro 1,4-diidroderivati
IT1215298B (it) * 1985-08-06 1990-01-31 Boehringer Biochemia Srl 2-(eteroalchil)-1,4-diidropiridine ed un processo per la loro produzione.
US4885284A (en) * 1986-01-22 1989-12-05 Nissan Chemical Industries Ltd. Dihydropyridine-5-phosphonic acid cyclic propylene ester
CN1016063B (zh) 1986-01-22 1992-04-01 日产化学工业株式会社 二氢吡啶-5-膦酸环亚丙基酯的制备
JPH0699458B2 (ja) * 1986-01-23 1994-12-07 日産化学工業株式会社 ジヒドロピリジン−５−ホスホン酸環状エステル類
JPS63115890A (ja) * 1986-10-31 1988-05-20 Nippon Shinyaku Co Ltd ２位置換１，４−ジヒドロピリジン誘導体
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
JP2850376B2 (ja) * 1988-08-02 1999-01-27 日産化学工業株式会社 抗癌剤薬効増強剤
ATE128623T1 (de) * 1988-08-02 1995-10-15 Nissan Chemical Ind Ltd Mittel zur verbesserung von arzneimitteleffekten für antitumormittel.
NZ542681A (en) * 2003-03-28 2009-01-31 Nissan Chemical Ind Ltd T-type calcium channel blockers comprising optically active 1,4-dihydropyridines
CA2787673A1 (en) 2010-03-01 2011-09-09 Tau Therapeutics Llc Cancer diagnosis and imaging

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin

Also Published As

Publication number Publication date
ES530248A0 (es) 1985-05-16
ES537717A0 (es) 1986-01-01
GB2140015B (en) 1987-07-29
GB2140015A (en) 1984-11-21
CA1254206A (en) 1989-05-16
DE3479582D1 (en) 1989-10-05
US4535073A (en) 1985-08-13
ES8505379A1 (es) 1985-05-16
EP0121117B1 (en) 1989-08-30
JPH0365351B2 (es) 1991-10-11
KR840007882A (ko) 1984-12-11
GB8404386D0 (en) 1984-03-28
JPS59161392A (ja) 1984-09-12
EP0121117A1 (en) 1984-10-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303