ES8604143A1 - Un procedimiento para preparar 4-aminoalquil-2(3h)-indolonas - Google Patents

Un procedimiento para preparar 4-aminoalquil-2(3h)-indolonas

Info

Publication number
ES8604143A1
ES8604143A1 ES543593A ES543593A ES8604143A1 ES 8604143 A1 ES8604143 A1 ES 8604143A1 ES 543593 A ES543593 A ES 543593A ES 543593 A ES543593 A ES 543593A ES 8604143 A1 ES8604143 A1 ES 8604143A1
Authority
ES
Spain
Prior art keywords
mono
alkyl
hydroxyphenethyl
allylamino
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543593A
Other languages
English (en)
Other versions
ES543593A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23776840&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8604143(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of ES8604143A1 publication Critical patent/ES8604143A1/es
Publication of ES543593A0 publication Critical patent/ES543593A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 4-AMINOALQUIL-2-(3H)-INDOLONAS Y DE SUS SALES DE ADICION DE ACIDOS DE FORMULA (I), EN LA QUE R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES; R1, R2 Y R3 REPRESENTAN HIDROGENO O ALQUILO C1-4; Y N VALE 1-3. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN 5-HALO-1-FENIL-1H-TETRAZOL REACTIVO, EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UN AGENTE DE FIJACION DE ACIDO, COMO UN CARBONATO DE METAL ALCALINO, A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y 75JC; SEGUIDA DE LA REDUCCION DE LA INDOLONA FORMADA MEDIANTE HIDROGENACION EN PRESENCIA DE PALADIO SOBRE CARBON A 50JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIANGINOSA.
ES543593A 1982-12-07 1985-05-29 Un procedimiento para preparar 4-aminoalquil-2(3h)-indolonas Expired ES8604143A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/447,564 US4452808A (en) 1982-12-07 1982-12-07 4-Aminoalkyl-2(3H)-indolones

Publications (2)

Publication Number Publication Date
ES8604143A1 true ES8604143A1 (es) 1986-01-16
ES543593A0 ES543593A0 (es) 1986-01-16

Family

ID=23776840

Family Applications (2)

Application Number Title Priority Date Filing Date
ES527827A Granted ES527827A0 (es) 1982-12-07 1983-12-06 Un procedimiento para preparar 4-aminoalquil-2(3h)-indolonas
ES543593A Expired ES8604143A1 (es) 1982-12-07 1985-05-29 Un procedimiento para preparar 4-aminoalquil-2(3h)-indolonas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES527827A Granted ES527827A0 (es) 1982-12-07 1983-12-06 Un procedimiento para preparar 4-aminoalquil-2(3h)-indolonas

Country Status (27)

Country Link
US (1) US4452808A (es)
EP (1) EP0113964B1 (es)
JP (1) JPS59112964A (es)
KR (1) KR910001042B1 (es)
AU (1) AU560170B2 (es)
BR (1) BR1100036A (es)
CA (1) CA1208650A (es)
CY (1) CY1497A (es)
CZ (1) CZ398191A3 (es)
DE (1) DE3367090D1 (es)
DK (1) DK156514C (es)
DZ (1) DZ587A1 (es)
EG (1) EG16556A (es)
ES (2) ES527827A0 (es)
FI (1) FI77849C (es)
GR (1) GR79121B (es)
HK (1) HK82089A (es)
IE (1) IE56347B1 (es)
IL (1) IL70311A (es)
LU (1) LU90097I2 (es)
NL (1) NL970005I2 (es)
NO (2) NO160135C (es)
NZ (1) NZ206344A (es)
PH (1) PH22067A (es)
PT (1) PT77739B (es)
ZA (1) ZA839094B (es)
ZW (1) ZW25883A1 (es)

Families Citing this family (62)

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US4588740A (en) * 1982-12-07 1986-05-13 Smithkline Beckman Corporation Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones
US4657929A (en) * 1983-10-25 1987-04-14 Fisons Plc Compounds
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
GB8621040D0 (en) * 1986-08-30 1986-10-08 Smith Kline French Lab Process
GB8712073D0 (en) * 1987-05-21 1987-06-24 Smith Kline French Lab Medicament
GB8714371D0 (en) * 1987-06-19 1987-07-22 Smith Kline French Lab Process
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
GB9015095D0 (en) * 1990-07-09 1990-08-29 Smith Kline French Lab Therapeutic method
IE914003A1 (en) * 1990-11-20 1992-05-20 Astra Pharma Prod Biologically Active Amines
WO1993023035A2 (en) * 1992-05-18 1993-11-25 Smithkline Beecham Plc Use of indolone derivatives for the treatment of memory disorders, sexual dysfunction and parkinson's disease
GB9300309D0 (en) * 1993-01-08 1993-03-03 Smithkline Beecham Plc Process
TW356468B (en) * 1995-09-15 1999-04-21 Astra Pharma Prod Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same
US5807570A (en) * 1995-09-29 1998-09-15 Cygnus, Inc. Transdermal administration of ropinirole and analogs thereof
GB9526511D0 (en) * 1995-12-23 1996-02-28 Astra Pharma Prod Pharmaceutically active compounds
AU4088897A (en) * 1996-08-27 1998-03-19 American Home Products Corporation 4-aminoethoxy indolone derivatives
WO1999052870A1 (en) * 1998-04-13 1999-10-21 American Home Products Corporation 4-amino-(ethylamino)-oxindole dopamine autoreceptor agonists
US6218421B1 (en) * 1999-07-01 2001-04-17 Smithkline Beecham P.L.C. Method of promoting smoking cessation
AR030557A1 (es) 2000-04-14 2003-08-27 Jagotec Ag Una tableta en multicapa de liberacion controlada y metodo de tratamiento
US6277875B1 (en) * 2000-07-17 2001-08-21 Andrew J. Holman Use of dopamine D2/D3 receptor agonists to treat fibromyalgia
DE10041478A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
US20020165246A1 (en) * 2001-03-05 2002-11-07 Andrew Holman Administration of sleep restorative agents
FR2821843B1 (fr) * 2001-03-12 2003-05-09 Servier Lab Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20030068356A1 (en) * 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
WO2004024163A1 (en) * 2002-09-13 2004-03-25 Motac Neuroscience Limited Treatment of basal ganglia-related movement disorders with 2,3-benzodiazepines
ATE360415T1 (de) * 2002-09-17 2007-05-15 Motac Neuroscience Ltd Behandlung von dyskinesie
ES2237307B1 (es) * 2003-10-14 2006-11-01 Urquima, S.A. Procedimiento para la preparacion de ropinirol.
WO2005074387A2 (en) * 2003-12-30 2005-08-18 Sun Pharmaceutical Industries Limited Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride
US7378439B2 (en) * 2004-01-20 2008-05-27 Usv, Ltd. Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride
WO2005105741A1 (en) * 2004-02-11 2005-11-10 Sun Pharmaceutical Industries Limited Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride
WO2005080333A1 (en) * 2004-02-19 2005-09-01 Torrent Pharmaceuticals Ltd Process for purification of ropinirole
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use
RS20060620A (sr) * 2004-05-11 2008-09-29 Egis Gyogyszergyar Nyrt., Piperazinski derivati alkil oksindola
US20050267096A1 (en) * 2004-05-26 2005-12-01 Pfizer Inc New indazole and indolone derivatives and their use pharmaceuticals
US20050288270A1 (en) * 2004-05-27 2005-12-29 Pfizer Inc New aminopyridine derivatives and their use as pharmaceuticals
JP2008533193A (ja) * 2005-03-21 2008-08-21 ファイザー・リミテッド オキシトシン拮抗薬としての置換トリアゾール誘導体
CN100457711C (zh) * 2005-06-27 2009-02-04 上海奥博生物医药技术有限公司 2-甲基-3-硝基苯基烷基胺衍生物或其盐的制备方法
WO2007010557A2 (en) * 2005-07-22 2007-01-25 Ind-Swift Laboratorie Limted Process for the preparation of highly pure ropinirole
CA2645599A1 (en) 2006-03-29 2007-10-04 Alembic Limited A process for the purification of ropinirole hydrochloride
ES2402376T3 (es) * 2006-04-06 2013-05-03 Nupathe Inc. Implantes para el tratamiento de estados asociados con dopamina
US20070254941A1 (en) * 2006-04-21 2007-11-01 Glenmark Pharmaceuticals Limited Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation
CN100457732C (zh) * 2006-05-25 2009-02-04 药源药物化学（上海）有限公司 罗匹尼罗的制备方法
WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
TW200815045A (en) * 2006-06-29 2008-04-01 Jazz Pharmaceuticals Inc Pharmaceutical compositions of ropinirole and methods of use thereof
RU2470635C2 (ru) * 2007-05-11 2012-12-27 Сантен Фармасьютикал Ко., Лтд. Профилактическое или терапевтическое средство, применяемое при заболеваниях заднего отдела глаза
US20090076124A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched ropinirole
US20090247537A1 (en) * 2008-03-25 2009-10-01 William Dale Overfield Methods for preventing or treating bruxism using dopaminergic agents
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TWI537274B (zh) 2011-03-14 2016-06-11 橘生藥品工業股份有限公司 新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途
KR101853082B1 (ko) 2011-03-24 2018-04-27 테이코쿠 팔마 유에스에이, 인코포레이티드 활성제층 및 활성제 변환층을 포함하는 경피 조성물
JP5913614B2 (ja) 2011-11-09 2016-04-27 テイコク ファーマ ユーエスエー インコーポレーテッド 皮膚新生物の処置方法
JP6050896B2 (ja) 2012-11-02 2016-12-21 テイコク ファーマ ユーエスエー インコーポレーテッド プロピニルアミノインダン経皮組成物
US9585885B2 (en) 2012-12-10 2017-03-07 Kissei Pharmaceutical Co., Ltd. Substituted pyrido[2,3-g]quinazolines as dopamine D2 receptor agonists
US9155695B2 (en) 2013-03-14 2015-10-13 Medtronic, Inc. Injectable ropinirole compositions and methods for making and using same
CN110621660B (zh) 2017-06-16 2022-06-28 浙江华海立诚药业有限公司 盐酸罗匹尼罗的纯化方法
CN115466209A (zh) * 2022-09-29 2022-12-13 南通大学 一种罗匹尼罗环戊烷并吲哚酮杂质的合成方法

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US3573310A (en) * 1967-09-28 1971-03-30 Miles Lab 1-substituted derivatives of 2-indolinone
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US4317944A (en) * 1980-08-15 1982-03-02 General Electric Company Preparation of 2,2-bis(4-hydroxyphenyl) propane
US4314944A (en) * 1980-08-22 1982-02-09 Smithkline Corporation 4-Aminoalkyl-7-hydroxy-2(3H)-indolones

Also Published As

Publication number Publication date
DZ587A1 (fr) 2004-09-13
EP0113964A1 (en) 1984-07-25
DK562183A (da) 1984-06-08
IL70311A0 (en) 1984-02-29
PH22067A (en) 1988-05-20
DK156514C (da) 1990-03-12
AU2158583A (en) 1984-06-14
KR840006963A (ko) 1984-12-04
KR910001042B1 (ko) 1991-02-21
CY1497A (en) 1990-02-16
NL970005I2 (nl) 1997-10-01
PT77739B (en) 1986-03-27
ZA839094B (en) 1985-02-27
DK156514B (da) 1989-09-04
PT77739A (en) 1983-12-01
AU560170B2 (en) 1987-04-02
HK82089A (en) 1989-10-20
US4452808A (en) 1984-06-05
ZW25883A1 (en) 1984-04-18
ES8600239A1 (es) 1985-10-01
DK562183D0 (da) 1983-12-06
NO160135B (no) 1988-12-05
EP0113964B1 (en) 1986-10-22
IE56347B1 (en) 1991-07-03
IL70311A (en) 1986-11-30
NL970005I1 (nl) 1997-04-01
GR79121B (es) 1984-10-02
FI77849B (fi) 1989-01-31
JPH0150703B2 (es) 1989-10-31
CZ398191A3 (en) 1993-02-17
IE832866L (en) 1984-06-07
ES527827A0 (es) 1985-10-01
LU90097I2 (fr) 1997-07-16
NO834485L (no) 1984-06-08
DE3367090D1 (de) 1986-11-27
BR1100036A (pt) 2000-01-11
CA1208650A (en) 1986-07-29
JPS59112964A (ja) 1984-06-29
NO1999011I1 (no) 1999-06-18
FI834421A0 (fi) 1983-12-02
ES543593A0 (es) 1986-01-16
NZ206344A (en) 1987-03-31
FI834421L (fi) 1984-06-08
FI77849C (fi) 1989-05-10
NO160135C (no) 1989-03-15
EG16556A (en) 1989-01-30

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Effective date: 20051013