ES8604174A1 - Procedimiento para la obtencion de isoxazoles - Google Patents

Procedimiento para la obtencion de isoxazoles

Info

Publication number
ES8604174A1
ES8604174A1 ES544191A ES544191A ES8604174A1 ES 8604174 A1 ES8604174 A1 ES 8604174A1 ES 544191 A ES544191 A ES 544191A ES 544191 A ES544191 A ES 544191A ES 8604174 A1 ES8604174 A1 ES 8604174A1
Authority
ES
Spain
Prior art keywords
isoxazole
methyl
isoxazoles
procedure
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544191A
Other languages
English (en)
Other versions
ES544191A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT, Biogal Gyogyszergyar Rt filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES544191A0 publication Critical patent/ES544191A0/es
Publication of ES8604174A1 publication Critical patent/ES8604174A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ISOXAZOLES. COMPRENDE: A) HIDROLIZAR AL ISOXAZOL-DERIVADO DE FORMULA (II) PARA OBTENER EL ACIDO ISOXAZOLCARBOXILICO DE FORMULA (III); B) ACTIVAR A (III) CON HALOGENURO DE ALQUILO, PARA REALIZAR UN COMPUESTO DE FORMULA (IV); C) TRATAR A (IV) CON MAGNESIO, PARA CONSEGUIR UN COMPUESTO DE FORMULA (V); D) HACER REACCIONAR A (V) CON HIDROCLORURO DE HIDROXILAMINA PARA REALIZAR UN COMPUESTO DE FORMULA (VI); E) TRATAR A (VI) CON ACIDO ACETICO CON BASE FUERTE, PARA OBTENER UN COMPUESTO DE FORMULA (VII); Y F) TRATAR A (VII) CON UNA BASE FUERTE, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: X E Y NITRILO, CARBOXILO DE -COOZ, ALQUILO DE C 1 A 6; Y Q HAL O ALCOXI CARBONILO DE C 1 A 5
ES544191A 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles Expired ES8604174A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU83661A HU189236B (en) 1983-02-28 1983-02-28 Process for producing new type isoxazoles

Publications (2)

Publication Number Publication Date
ES544191A0 ES544191A0 (es) 1986-01-16
ES8604174A1 true ES8604174A1 (es) 1986-01-16

Family

ID=10950718

Family Applications (3)

Application Number Title Priority Date Filing Date
ES530121A Granted ES530121A0 (es) 1983-02-28 1984-02-28 Procedimiento para la obtencion de isoxazoles
ES544191A Expired ES8604174A1 (es) 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles
ES544192A Expired ES8604175A1 (es) 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES530121A Granted ES530121A0 (es) 1983-02-28 1984-02-28 Procedimiento para la obtencion de isoxazoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES544192A Expired ES8604175A1 (es) 1983-02-28 1985-06-14 Procedimiento para la obtencion de isoxazoles

Country Status (12)

Country Link
JP (1) JPS59164784A (es)
BE (1) BE899007A (es)
CH (1) CH658655A5 (es)
DE (1) DE3405422A1 (es)
ES (3) ES530121A0 (es)
FR (1) FR2541678A1 (es)
GB (1) GB2135996B (es)
HU (1) HU189236B (es)
IT (1) IT1174498B (es)
NL (1) NL8400575A (es)
PT (1) PT78157B (es)
SE (1) SE8401064L (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366987A (en) * 1991-08-22 1994-11-22 Warner-Lambert Company Isoxazolyl-substituted alkyl amide ACAT inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163057A (en) * 1977-12-27 1979-07-31 Sandoz, Inc. Isoxazole-4-carboxamides as tranquilizers, sleep-inducers and muscle relaxants

Also Published As

Publication number Publication date
ES544192A0 (es) 1986-01-16
ES544191A0 (es) 1986-01-16
GB2135996A (en) 1984-09-12
PT78157B (de) 1986-05-19
PT78157A (de) 1984-03-01
DE3405422A1 (de) 1984-08-30
GB8405001D0 (en) 1984-04-04
FR2541678A1 (fr) 1984-08-31
SE8401064D0 (sv) 1984-02-27
GB2135996B (en) 1986-09-10
SE8401064L (sv) 1984-08-29
IT1174498B (it) 1987-07-01
HU189236B (en) 1986-06-30
BE899007A (fr) 1984-08-27
ES8601935A1 (es) 1985-11-16
ES530121A0 (es) 1985-11-16
NL8400575A (nl) 1984-09-17
JPS59164784A (ja) 1984-09-17
CH658655A5 (de) 1986-11-28
IT8419806A0 (it) 1984-02-27
ES8604175A1 (es) 1986-01-16

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