ES8604594A1 - Un procedimiento para la preparacion de compuestos de espi- ro-imidazolona - Google Patents

Un procedimiento para la preparacion de compuestos de espi- ro-imidazolona

Info

Publication number
ES8604594A1
ES8604594A1 ES545353A ES545353A ES8604594A1 ES 8604594 A1 ES8604594 A1 ES 8604594A1 ES 545353 A ES545353 A ES 545353A ES 545353 A ES545353 A ES 545353A ES 8604594 A1 ES8604594 A1 ES 8604594A1
Authority
ES
Spain
Prior art keywords
procedure
preparation
spiral
imidazolone compounds
imidazolone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545353A
Other languages
English (en)
Other versions
ES545353A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES545353A0 publication Critical patent/ES545353A0/es
Publication of ES8604594A1 publication Critical patent/ES8604594A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE ESPIRO-IMIDAZOLONA. CONSISTE EN CICLIZAR A UN COMPUESTO DE FORMULA (II) CON ACIDO DE LEWIS COMO ACIDO SULFURICO O POLIFOSFORICO CONCENTRADO CALIENTE, EN UN DISOLVENTE COMO BENCENO O TOLUENO Y A UNA TEMPERATURA ENTRE 50JC Y 60JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES BASICAS CON CATIONES Y FARMACEUTICAMENTE ACEPTABLES. SIENDO: X, O O S; Y, H, HAL O ALQUILO DE C 1 A 4; Y R, H, METILO O ETILO. SE UTILIZA PARA EL TRATAMIENTO DE CATARATAS DIABETICAS, RETINOPATIA Y NEUROPATIA.
ES545353A 1984-07-20 1985-07-18 Un procedimiento para la preparacion de compuestos de espi- ro-imidazolona Expired ES8604594A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1984/001155 WO1986000807A1 (en) 1984-07-20 1984-07-20 Spiro-imidazolones for treatment of diabetes complications

Publications (2)

Publication Number Publication Date
ES545353A0 ES545353A0 (es) 1986-02-01
ES8604594A1 true ES8604594A1 (es) 1986-02-01

Family

ID=22182207

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545353A Expired ES8604594A1 (es) 1984-07-20 1985-07-18 Un procedimiento para la preparacion de compuestos de espi- ro-imidazolona

Country Status (19)

Country Link
US (1) US4680306A (es)
EP (1) EP0171213B1 (es)
KR (1) KR870000626B1 (es)
AT (1) ATE37372T1 (es)
AU (1) AU553719B2 (es)
CA (1) CA1246085A (es)
DE (1) DE3565106D1 (es)
DK (1) DK329485A (es)
EG (1) EG17281A (es)
ES (1) ES8604594A1 (es)
FI (1) FI80037C (es)
GR (1) GR851763B (es)
HU (1) HU198212B (es)
IL (1) IL75801A (es)
PH (1) PH21886A (es)
PL (1) PL145598B1 (es)
PT (1) PT80829B (es)
WO (1) WO1986000807A1 (es)
ZA (1) ZA855460B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3501B1 (ar) * 2014-12-22 2020-07-05 Servier Lab مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985888A (en) * 1969-07-24 1976-10-12 Richardson-Merrell Inc. Methods of inducing sedation using certain spiroalkanone-imides
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4127665A (en) * 1978-01-18 1978-11-28 Pfizer Inc. Thienohydantoin derivatives
US4147797A (en) * 1978-08-11 1979-04-03 Pfizer Inc. Spiro-furanohydantoin derivatives
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
IE52879B1 (en) * 1981-05-12 1988-03-30 Ici Plc Pharmaceutical spiro-hydantoin derivatives
ATE11781T1 (de) * 1981-05-13 1985-02-15 Imperial Chemical Industries Plc Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten.
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use

Also Published As

Publication number Publication date
US4680306A (en) 1987-07-14
FI80037C (fi) 1990-04-10
EG17281A (en) 1989-06-30
PL254593A1 (en) 1986-06-17
PT80829B (pt) 1987-11-30
ATE37372T1 (de) 1988-10-15
IL75801A (en) 1988-09-30
PT80829A (en) 1985-08-01
GR851763B (es) 1985-11-26
DK329485D0 (da) 1985-07-19
PL145598B1 (en) 1988-10-31
KR870000626B1 (ko) 1987-03-26
FI861125A0 (fi) 1986-03-18
AU4518985A (en) 1986-01-23
AU553719B2 (en) 1986-07-24
DE3565106D1 (en) 1988-10-27
FI80037B (fi) 1989-12-29
HU198212B (en) 1989-08-28
ZA855460B (en) 1987-02-25
FI861125L (fi) 1986-03-18
ES545353A0 (es) 1986-02-01
DK329485A (da) 1986-01-21
EP0171213B1 (en) 1988-09-21
IL75801A0 (en) 1985-11-29
HUT39087A (en) 1986-08-28
CA1246085A (en) 1988-12-06
PH21886A (en) 1988-03-25
KR860001114A (ko) 1986-02-22
EP0171213A1 (en) 1986-02-12
WO1986000807A1 (en) 1986-02-13

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