ES8606244A1 - Procedimiento para la obtencion de nuevos derivados de pro- pilamina - Google Patents

Procedimiento para la obtencion de nuevos derivados de pro- pilamina

Info

Publication number
ES8606244A1
ES8606244A1 ES541258A ES541258A ES8606244A1 ES 8606244 A1 ES8606244 A1 ES 8606244A1 ES 541258 A ES541258 A ES 541258A ES 541258 A ES541258 A ES 541258A ES 8606244 A1 ES8606244 A1 ES 8606244A1
Authority
ES
Spain
Prior art keywords
compound
formula
lower alkyl
group
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541258A
Other languages
English (en)
Other versions
ES541258A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES541258A0 publication Critical patent/ES541258A0/es
Publication of ES8606244A1 publication Critical patent/ES8606244A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PROPILAMINA Y DE SUS SALES DE ADICION DE ACIDOS Y SALES CUATERNARIAS, DE FORMULA (I), EN LA QUE R1, R2, R3, AR Y X PUEDEN SER VARIOS TIPOS DE RADICALES, Y N VALE 1 A 3. CONSISTE EN LA REACCION DE CONDENSACION DE UNA AMINA, DE FORMULA R1NHR2, O UNA DE SUS SALES DE ADICION DE ACIDO, CON UN COMPUESTO DE FORMULA (II), EN LAS QUE Z REPRESENTA HIDROGENO JUNTO CON UN GRUPO HIDROXI ESTERIFICADO, O EL GRUPO OXO, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN LAS CONDICIONES CONVENCIONALES DE UNA ALQUILACION REDUCTIVA DE AMINAS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA DEPRESION Y OTRAS PERTURBACIONES DEL SISTEMA NERVIOSO CENTRAL.
ES541258A 1982-09-07 1985-03-14 Procedimiento para la obtencion de nuevos derivados de pro- pilamina Expired ES8606244A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41500082A 1982-09-07 1982-09-07

Publications (2)

Publication Number Publication Date
ES541258A0 ES541258A0 (es) 1986-04-01
ES8606244A1 true ES8606244A1 (es) 1986-04-01

Family

ID=23643932

Family Applications (4)

Application Number Title Priority Date Filing Date
ES525400A Granted ES525400A0 (es) 1982-09-07 1983-09-06 Procedimiento para la obtencion de nuevos derivados de propilamina
ES541258A Expired ES8606244A1 (es) 1982-09-07 1985-03-14 Procedimiento para la obtencion de nuevos derivados de pro- pilamina
ES541260A Expired ES8802010A1 (es) 1982-09-07 1985-03-14 Procedimiento para la obtencion de nuevos derivados de pro- pilamina
ES541259A Expired ES8702335A1 (es) 1982-09-07 1985-03-14 Procedimiento para la obtencion de nuevos derivados de pro- pilamina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES525400A Granted ES525400A0 (es) 1982-09-07 1983-09-06 Procedimiento para la obtencion de nuevos derivados de propilamina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES541260A Expired ES8802010A1 (es) 1982-09-07 1985-03-14 Procedimiento para la obtencion de nuevos derivados de pro- pilamina
ES541259A Expired ES8702335A1 (es) 1982-09-07 1985-03-14 Procedimiento para la obtencion de nuevos derivados de pro- pilamina

Country Status (18)

Country Link
EP (1) EP0102929B1 (es)
JP (1) JPS5973546A (es)
AT (1) ATE28069T1 (es)
AU (1) AU566564B2 (es)
CA (1) CA1242728A (es)
DD (1) DD213208A5 (es)
DE (1) DE3372283D1 (es)
DK (1) DK405183A (es)
ES (4) ES525400A0 (es)
FI (1) FI83632C (es)
GR (1) GR78936B (es)
HU (1) HU194157B (es)
IE (1) IE55906B1 (es)
IL (1) IL69632A (es)
NO (1) NO157975C (es)
NZ (1) NZ205509A (es)
PT (1) PT77291B (es)
ZA (1) ZA836597B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1417174A2 (en) * 2001-08-08 2004-05-12 Neurosearch A/S Substituted amine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1237352A (en) * 1969-01-03 1971-06-30 Ct Europ De Rech S Mauvernay Substituted propylamines
GB1343527A (en) * 1971-07-30 1974-01-10 Cerm Cent Europ Rech Mauvernay Amino-propanol derivatives
FR2460919A1 (fr) * 1979-07-11 1981-01-30 Prod Synthese Ste Indle Amino-ethers oxydes, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
PT77291A (en) 1983-10-01
IE55906B1 (en) 1991-02-14
AU1874683A (en) 1984-03-15
ES8506582A1 (es) 1985-08-01
NO157975B (no) 1988-03-14
DK405183D0 (da) 1983-09-06
ES541258A0 (es) 1986-04-01
NZ205509A (en) 1987-07-31
DE3372283D1 (en) 1987-08-06
ES541259A0 (es) 1986-12-16
ES8702335A1 (es) 1986-12-16
EP0102929B1 (de) 1987-07-01
CA1242728A (en) 1988-10-04
ES8802010A1 (es) 1988-03-16
DD213208A5 (de) 1984-09-05
EP0102929A3 (en) 1984-09-12
IE832093L (en) 1984-03-07
IL69632A0 (en) 1983-12-30
FI83632B (fi) 1991-04-30
NO833178L (no) 1984-03-08
ZA836597B (en) 1984-04-25
EP0102929A2 (de) 1984-03-14
PT77291B (en) 1986-07-14
IL69632A (en) 1987-08-31
NO157975C (no) 1988-06-28
FI833150A7 (fi) 1984-03-08
AU566564B2 (en) 1987-10-22
HU194157B (en) 1988-01-28
JPS5973546A (ja) 1984-04-25
FI833150A0 (fi) 1983-09-05
ATE28069T1 (de) 1987-07-15
FI83632C (fi) 1991-08-12
ES541260A0 (es) 1988-03-16
GR78936B (es) 1984-10-02
DK405183A (da) 1984-03-08
ES525400A0 (es) 1985-08-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203