ES8802010A1 - Procedimiento para la obtencion de nuevos derivados de pro- pilamina - Google Patents
Procedimiento para la obtencion de nuevos derivados de pro- pilaminaInfo
- Publication number
- ES8802010A1 ES8802010A1 ES541260A ES541260A ES8802010A1 ES 8802010 A1 ES8802010 A1 ES 8802010A1 ES 541260 A ES541260 A ES 541260A ES 541260 A ES541260 A ES 541260A ES 8802010 A1 ES8802010 A1 ES 8802010A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- formula
- lower alkyl
- group
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 22
- 238000000034 method Methods 0.000 title abstract 4
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical class CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 150000003839 salts Chemical class 0.000 abstract 12
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 229910052760 oxygen Inorganic materials 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004043 oxo group Chemical group O=* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 2
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- -1 azidomethyl Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 150000002541 isothioureas Chemical class 0.000 abstract 1
- 150000002542 isoureas Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000002829 reductive effect Effects 0.000 abstract 1
- 238000009738 saturating Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LOS DERIVADOS DE PROPILAMINA (I), DONDE NO EXCLUSIVAMENTE, R1 Y R2 SON ALQUILO INFERIOR O JUNTO CON EL N, SON PIPERIDINO O PIRROLIDINO, R3 ALQUILO INFERIOR O HALOGENO, AR ES FENILO, X OXIGENO O AZUFRE Y N ES 1, 2 O 3; SE OBTIENEN SATURANDO CON HIDROGENO UN COMPUESTO (II), MEDIANTE UNA HIDROGENACION EXHAUSTIVA DE SU SOLUCION EN ETANOL, MEDIANTE UN CATALIZADOR CONSTITUIDO POR UN 5% DE PALADIO SOBRE CARBON, QUE POSTERIORMENTE SE SEPARA POR FILTRACION, QUEDANDO EL PRODUCTO EN FORMA DE ACEITE DESPUES DE SEPARAR EL ETANOL, Y FINALMENTE SE FORMA EL OXALATO CORRESPONDIENTE. TIENEN ENTRE OTRAS LA PROPIEDAD DE INHIBIRSELECTIVAMENTE LA RECEPCION DE SEROTONINA DE LAS CELULAS NERVIOSAS CEREBRALES Y DE LA RECEPCION NEURONAL DE LA NOREPINETRINA (NE), POR LO QUE SE PUEDEN EMPLEAR PARA EL TRATAMIENTO DE LA DEPRESION Y OTRAS PERTURBACIONES DEL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41500082A | 1982-09-07 | 1982-09-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8802010A1 true ES8802010A1 (es) | 1988-03-16 |
| ES541260A0 ES541260A0 (es) | 1988-03-16 |
Family
ID=23643932
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525400A Granted ES525400A0 (es) | 1982-09-07 | 1983-09-06 | Procedimiento para la obtencion de nuevos derivados de propilamina |
| ES541258A Expired ES8606244A1 (es) | 1982-09-07 | 1985-03-14 | Procedimiento para la obtencion de nuevos derivados de pro- pilamina |
| ES541260A Expired ES8802010A1 (es) | 1982-09-07 | 1985-03-14 | Procedimiento para la obtencion de nuevos derivados de pro- pilamina |
| ES541259A Expired ES8702335A1 (es) | 1982-09-07 | 1985-03-14 | Procedimiento para la obtencion de nuevos derivados de pro- pilamina |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525400A Granted ES525400A0 (es) | 1982-09-07 | 1983-09-06 | Procedimiento para la obtencion de nuevos derivados de propilamina |
| ES541258A Expired ES8606244A1 (es) | 1982-09-07 | 1985-03-14 | Procedimiento para la obtencion de nuevos derivados de pro- pilamina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES541259A Expired ES8702335A1 (es) | 1982-09-07 | 1985-03-14 | Procedimiento para la obtencion de nuevos derivados de pro- pilamina |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0102929B1 (es) |
| JP (1) | JPS5973546A (es) |
| AT (1) | ATE28069T1 (es) |
| AU (1) | AU566564B2 (es) |
| CA (1) | CA1242728A (es) |
| DD (1) | DD213208A5 (es) |
| DE (1) | DE3372283D1 (es) |
| DK (1) | DK405183A (es) |
| ES (4) | ES525400A0 (es) |
| FI (1) | FI83632C (es) |
| GR (1) | GR78936B (es) |
| HU (1) | HU194157B (es) |
| IE (1) | IE55906B1 (es) |
| IL (1) | IL69632A (es) |
| NO (1) | NO157975C (es) |
| NZ (1) | NZ205509A (es) |
| PT (1) | PT77291B (es) |
| ZA (1) | ZA836597B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1417174A2 (en) * | 2001-08-08 | 2004-05-12 | Neurosearch A/S | Substituted amine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1237352A (en) * | 1969-01-03 | 1971-06-30 | Ct Europ De Rech S Mauvernay | Substituted propylamines |
| GB1343527A (en) * | 1971-07-30 | 1974-01-10 | Cerm Cent Europ Rech Mauvernay | Amino-propanol derivatives |
| FR2460919A1 (fr) * | 1979-07-11 | 1981-01-30 | Prod Synthese Ste Indle | Amino-ethers oxydes, leur procede de preparation et leur application en therapeutique |
-
1983
- 1983-09-01 DE DE8383810398T patent/DE3372283D1/de not_active Expired
- 1983-09-01 EP EP83810398A patent/EP0102929B1/de not_active Expired
- 1983-09-01 AT AT83810398T patent/ATE28069T1/de not_active IP Right Cessation
- 1983-09-02 IL IL69632A patent/IL69632A/xx unknown
- 1983-09-02 CA CA000435963A patent/CA1242728A/en not_active Expired
- 1983-09-05 DD DD83254530A patent/DD213208A5/de not_active IP Right Cessation
- 1983-09-05 FI FI833150A patent/FI83632C/fi not_active IP Right Cessation
- 1983-09-06 PT PT77291A patent/PT77291B/pt not_active IP Right Cessation
- 1983-09-06 ES ES525400A patent/ES525400A0/es active Granted
- 1983-09-06 AU AU18746/83A patent/AU566564B2/en not_active Ceased
- 1983-09-06 IE IE2093/83A patent/IE55906B1/en not_active IP Right Cessation
- 1983-09-06 HU HU833100A patent/HU194157B/hu unknown
- 1983-09-06 NZ NZ205509A patent/NZ205509A/en unknown
- 1983-09-06 DK DK405183A patent/DK405183A/da not_active Application Discontinuation
- 1983-09-06 NO NO833178A patent/NO157975C/no unknown
- 1983-09-06 GR GR72391A patent/GR78936B/el unknown
- 1983-09-06 JP JP58162720A patent/JPS5973546A/ja active Pending
- 1983-09-06 ZA ZA836597A patent/ZA836597B/xx unknown
-
1985
- 1985-03-14 ES ES541258A patent/ES8606244A1/es not_active Expired
- 1985-03-14 ES ES541260A patent/ES8802010A1/es not_active Expired
- 1985-03-14 ES ES541259A patent/ES8702335A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| PT77291A (en) | 1983-10-01 |
| IE55906B1 (en) | 1991-02-14 |
| AU1874683A (en) | 1984-03-15 |
| ES8506582A1 (es) | 1985-08-01 |
| NO157975B (no) | 1988-03-14 |
| DK405183D0 (da) | 1983-09-06 |
| ES541258A0 (es) | 1986-04-01 |
| NZ205509A (en) | 1987-07-31 |
| DE3372283D1 (en) | 1987-08-06 |
| ES541259A0 (es) | 1986-12-16 |
| ES8702335A1 (es) | 1986-12-16 |
| EP0102929B1 (de) | 1987-07-01 |
| CA1242728A (en) | 1988-10-04 |
| DD213208A5 (de) | 1984-09-05 |
| EP0102929A3 (en) | 1984-09-12 |
| IE832093L (en) | 1984-03-07 |
| IL69632A0 (en) | 1983-12-30 |
| FI83632B (fi) | 1991-04-30 |
| NO833178L (no) | 1984-03-08 |
| ZA836597B (en) | 1984-04-25 |
| EP0102929A2 (de) | 1984-03-14 |
| PT77291B (en) | 1986-07-14 |
| IL69632A (en) | 1987-08-31 |
| NO157975C (no) | 1988-06-28 |
| ES8606244A1 (es) | 1986-04-01 |
| FI833150A7 (fi) | 1984-03-08 |
| AU566564B2 (en) | 1987-10-22 |
| HU194157B (en) | 1988-01-28 |
| JPS5973546A (ja) | 1984-04-25 |
| FI833150A0 (fi) | 1983-09-05 |
| ATE28069T1 (de) | 1987-07-15 |
| FI83632C (fi) | 1991-08-12 |
| ES541260A0 (es) | 1988-03-16 |
| GR78936B (es) | 1984-10-02 |
| DK405183A (da) | 1984-03-08 |
| ES525400A0 (es) | 1985-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |