ES8606884A1 - Un procedimiento para preparar una composicion citotoxica - Google Patents

Un procedimiento para preparar una composicion citotoxica

Info

Publication number
ES8606884A1
ES8606884A1 ES544846A ES544846A ES8606884A1 ES 8606884 A1 ES8606884 A1 ES 8606884A1 ES 544846 A ES544846 A ES 544846A ES 544846 A ES544846 A ES 544846A ES 8606884 A1 ES8606884 A1 ES 8606884A1
Authority
ES
Spain
Prior art keywords
selective
binding agent
preparing
procedure
copulated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544846A
Other languages
English (en)
Other versions
ES544846A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of ES8606884A1 publication Critical patent/ES8606884A1/es
Publication of ES544846A0 publication Critical patent/ES544846A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/54—Polycondensates of aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6819—Plant toxins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y10S436/813—Cancer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/819—Multifunctional antigen or antibody
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

METODO DE PREPARACION DE COMPOSICIONES CITOTOXICAS. COMPRENDE LA COMBINACION DE UN PRIMER CONJUGADO QUE CONTIENE UN AGENTE ENLAZANTE DE AFINIDAS SELECTIVA, COPULADO DE FORMA COVALENTE CON UN RESTO DE LA CADENA B DE UNA TOXINA, CON UN SEGUNDO CONJUGADO QUE CONTIENE UN AGENTE ENLAZANTE DE AFINIDAS SELECTIVA, TAL COMO UN ANTICUERPO MONOCLONAL O UN FRAGMENTO DEL MISMO, DIRIGIDO CONTRA UN DETERMINADO ANTIGENO DE LA SUPERFICIE DE LA CELULA, COPULADO CON UN AGENTE COPULANTE, A UN RESTO DE LA CADENA A DE LA TOXINA, A UNA TEMPERATURA COMPRENDIDAS ENTRE 0JC Y 37JC. ESTAS COMPOSICIONES TIENEN APLICACIONES FARMACOLOGICAS PARA LA ELIMINACION DE CELULAS INDESEABLES EN PARTICULAR PARA LA TERAPIA DE TUMORES.
ES544846A 1983-06-21 1985-07-03 Un procedimiento para preparar una composicion citotoxica Expired ES8606884A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/506,540 US4664911A (en) 1983-06-21 1983-06-21 Immunotoxin conjugates employing toxin B chain moieties

Publications (2)

Publication Number Publication Date
ES8606884A1 true ES8606884A1 (es) 1986-04-16
ES544846A0 ES544846A0 (es) 1986-04-16

Family

ID=24015007

Family Applications (2)

Application Number Title Priority Date Filing Date
ES533510A Expired ES8604425A1 (es) 1983-06-21 1984-06-18 Un procedimiento para preparar un conjugado de la cadena b de una toxina
ES544846A Expired ES8606884A1 (es) 1983-06-21 1985-07-03 Un procedimiento para preparar una composicion citotoxica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES533510A Expired ES8604425A1 (es) 1983-06-21 1984-06-18 Un procedimiento para preparar un conjugado de la cadena b de una toxina

Country Status (18)

Country Link
US (1) US4664911A (es)
EP (1) EP0129434B1 (es)
JP (1) JPH0639387B2 (es)
KR (1) KR860001803B1 (es)
AT (1) ATE46084T1 (es)
AU (1) AU570049B2 (es)
CA (1) CA1232838A (es)
DE (1) DE3479633D1 (es)
DK (1) DK297184A (es)
ES (2) ES8604425A1 (es)
FI (1) FI842420A7 (es)
GB (1) GB2142032B (es)
GR (1) GR82368B (es)
HU (1) HUT34348A (es)
IL (1) IL72117A0 (es)
PL (1) PL248202A1 (es)
PT (1) PT78752A (es)
ZA (1) ZA844512B (es)

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FR2504010B1 (fr) * 1981-04-15 1985-10-25 Sanofi Sa Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
JPS5874614A (ja) * 1981-10-30 1983-05-06 Teijin Ltd 蛋白複合体及びその製造法
FR2516794B1 (fr) * 1981-11-20 1985-10-25 Sanofi Sa Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique
FR2536997B1 (fr) * 1982-03-11 1987-08-07 Sanofi Sa Medicaments cytotoxiques comportant au moins une immunotoxine et de la methylamine
FR2523445A1 (fr) * 1982-03-17 1983-09-23 Sanofi Sa Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues
US4500637A (en) * 1982-07-19 1985-02-19 The United States Of America As Represented By The Department Of Health And Human Services Prevention of graft versus host disease following bone marrow transplantation

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KR860001803B1 (ko) 1986-10-23
DE3479633D1 (en) 1989-10-12
EP0129434A2 (en) 1984-12-27
AU570049B2 (en) 1988-03-03
CA1232838A (en) 1988-02-16
GR82368B (es) 1984-12-13
ES544846A0 (es) 1986-04-16
JPH0639387B2 (ja) 1994-05-25
ES533510A0 (es) 1986-02-01
EP0129434B1 (en) 1989-09-06
GB2142032B (en) 1987-05-13
AU2948084A (en) 1985-01-03
IL72117A0 (en) 1984-10-31
ZA844512B (en) 1986-02-26
KR850000248A (ko) 1985-02-26
FI842420A0 (fi) 1984-06-14
ATE46084T1 (de) 1989-09-15
GB2142032A (en) 1985-01-09
PT78752A (en) 1984-07-01
EP0129434A3 (en) 1985-09-18
HUT34348A (en) 1985-03-28
DK297184D0 (da) 1984-06-18
PL248202A1 (en) 1985-03-26
JPS6069033A (ja) 1985-04-19
FI842420L (fi) 1984-12-22
GB8415507D0 (en) 1984-07-25
US4664911A (en) 1987-05-12
FI842420A7 (fi) 1984-12-22
ES8604425A1 (es) 1986-02-01
DK297184A (da) 1984-12-22

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