ES8607986A1 - Derivados de androsteno nuevos - Google Patents

Derivados de androsteno nuevos

Info

Publication number
ES8607986A1
ES8607986A1 ES539508A ES539508A ES8607986A1 ES 8607986 A1 ES8607986 A1 ES 8607986A1 ES 539508 A ES539508 A ES 539508A ES 539508 A ES539508 A ES 539508A ES 8607986 A1 ES8607986 A1 ES 8607986A1
Authority
ES
Spain
Prior art keywords
derivatives
androstene
delta5
delta4
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539508A
Other languages
English (en)
Other versions
ES539508A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of ES8607986A1 publication Critical patent/ES8607986A1/es
Publication of ES539508A0 publication Critical patent/ES539508A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE Q4- Y Q5-ANDROSTENO, DE FORMULA (I), EN LA QUE X, R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DEL SULFONATO DEL CORRESPONDIENTE COMPUESTO 19-HIDROXI-METALICO CON UNA SAL METALICA DE UN COMPUESTO DE FORMULA R3SH, EN LA QUE R3 REPRESENTA HIDROGENO, ACILO C1-18 O ALQUILO C1-4, SEGUIDA DE LA HIDROLISIS DEL COMPUESTO 19-ACILTIOMETILICO ASI OBTENIDO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 5JC Y 125º C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO INHIBIDORES DE AROMATASA.
ES539508A 1984-01-14 1985-01-11 Derivados de androsteno nuevos Expired ES8607986A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8400126 1984-01-14

Publications (2)

Publication Number Publication Date
ES8607986A1 true ES8607986A1 (es) 1986-06-01
ES539508A0 ES539508A0 (es) 1986-06-01

Family

ID=19843328

Family Applications (2)

Application Number Title Priority Date Filing Date
ES539508A Expired ES8607986A1 (es) 1984-01-14 1985-01-11 Derivados de androsteno nuevos
ES551755A Expired ES8702429A1 (es) 1984-01-14 1986-02-07 Un procedimiento para la preparacion de derivados de d4-y-d5-androsteno nuevos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES551755A Expired ES8702429A1 (es) 1984-01-14 1986-02-07 Un procedimiento para la preparacion de derivados de d4-y-d5-androsteno nuevos

Country Status (11)

Country Link
US (1) US4634694A (es)
EP (1) EP0149499B1 (es)
JP (1) JPS60158198A (es)
KR (1) KR920002827B1 (es)
AU (1) AU564516B2 (es)
DE (1) DE3573428D1 (es)
DK (1) DK15685A (es)
ES (2) ES8607986A1 (es)
FI (1) FI83088C (es)
HU (1) HU192286B (es)
ZA (1) ZA85143B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3714964A1 (de) * 1987-04-30 1988-11-10 Schering Ag 15-alkyl-19-thio-4-androsten-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
EP0334425A1 (en) * 1988-03-24 1989-09-27 Akzo N.V. Novel delta4 - androstene derivatives
FR2656310B1 (fr) * 1989-12-22 1992-05-07 Roussel Uclaf Nouveaux produits sterouides comportant en position 10, un radical thioethyle substitue, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
FR2668945B1 (fr) * 1990-11-12 1993-02-19 Theramex Nouveau procede de cristallisation des substances organiques et les composes ainsi obtenus.
FR2677027B1 (fr) * 1991-05-27 1993-09-10 Roussel Uclaf Nouveaux produits sterouides substitues en position 6, et comportant, en position 10, un radical thioethyle, leur procede de preparation leurs intermediaires, leur application comme medicaments.
KR20060098399A (ko) * 1998-06-11 2006-09-18 앙도르쉐르슈 인코포레이티드 안드로스트-5-엔-3β,17β-디올을 포함하는 약학 조성물 및그 용도
US6868575B2 (en) 2000-01-31 2005-03-22 George Koregelos Cleaning device
US8084446B2 (en) 2005-04-26 2011-12-27 Eric Marchewitz Use of DHEA derivatives for enhancing physical performance
US20160362442A1 (en) * 2015-06-10 2016-12-15 IronMag Labs Method For DHEA Enanthate Processing
US20160362443A1 (en) * 2015-06-10 2016-12-15 IronMags Labs Method For DHEA Enanthate Processing

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
US4289762A (en) * 1980-06-27 1981-09-15 Merrell Dow Pharmaceuticals Inc. 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
EP0100566B1 (en) * 1982-07-14 1986-02-19 Akzo N.V. Novel 19-thio-androstane derivatives
DD209979A5 (de) * 1982-08-03 1984-05-30 Politechnika Swietokrzyska Magnetabscheider
US4473564A (en) * 1983-07-12 1984-09-25 Akzo N.V. 19-Thio-androstane derivatives

Also Published As

Publication number Publication date
AU3761985A (en) 1985-07-18
ES8702429A1 (es) 1986-12-16
HU192286B (en) 1987-05-28
FI83088B (fi) 1991-02-15
EP0149499A2 (en) 1985-07-24
ES551755A0 (es) 1986-12-16
JPS60158198A (ja) 1985-08-19
US4634694A (en) 1987-01-06
AU564516B2 (en) 1987-08-13
KR850005453A (ko) 1985-08-26
DK15685A (da) 1985-07-15
DK15685D0 (da) 1985-01-11
FI83088C (fi) 1991-05-27
ZA85143B (en) 1985-08-28
FI850064A0 (fi) 1985-01-07
HUT37632A (en) 1986-01-23
ES539508A0 (es) 1986-06-01
FI850064L (fi) 1985-07-15
DE3573428D1 (en) 1989-11-09
EP0149499A3 (en) 1985-08-14
KR920002827B1 (ko) 1992-04-04
EP0149499B1 (en) 1989-10-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203