ES8608530A1 - Procedimiento de obtencion de nuevos derivados de la oxaazo-fosforina - Google Patents

Procedimiento de obtencion de nuevos derivados de la oxaazo-fosforina

Info

Publication number
ES8608530A1
ES8608530A1 ES544927A ES544927A ES8608530A1 ES 8608530 A1 ES8608530 A1 ES 8608530A1 ES 544927 A ES544927 A ES 544927A ES 544927 A ES544927 A ES 544927A ES 8608530 A1 ES8608530 A1 ES 8608530A1
Authority
ES
Spain
Prior art keywords
oxaazo
phosphorine
procedure
obtaining new
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544927A
Other languages
English (en)
Other versions
ES544927A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Servier de Medecine Translationnelle SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES544927A0 publication Critical patent/ES544927A0/es
Publication of ES8608530A1 publication Critical patent/ES8608530A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA OBTENER NUEVOS DERIVADOS DE OXAAZOFOSFORINA. COMPRENDE: A) CONDENSAR A UN DICLORURO DE ACIDO FOSFORICO D.F. (II) CON EL 3-AMINO-1-PROPANOL EN TOLUENO, EN HIDROXIDO SODICO Y ENTRE C30 Y 0JC, PARA OBTENER UN C.D.F. (III); B) TRATAR A (III) CON EXCESO DE B-CLOROETILISOCIANATO D.F. (IV), PARA FORMAR UN C.D.F. (V); Y C) NITROSAR A (V) CON CLORURO DE NITROSILO, EN UN DISOLVENTE MEZCLA DE BUTIL-LITIO/TETRAHIDROFURANO Y A C80JC, PARA OBTENER UN C.D.F. (I) Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. SIENDO: C.D.F., COMPUESTO D.F.; D.F., DE FORMULA; Y R UN ALQUILO DE CADENA LINEAL O RAMIFICADA DE C 1 A 6, UN GRUPO CICLOALQUILO DE C 3 A 7 Y OTROS. SE UTILIZAN EN QUIMIOTERAPIA ANTICANCEROSA.
ES544927A 1984-07-06 1985-07-05 Procedimiento de obtencion de nuevos derivados de la oxaazo-fosforina Expired ES8608530A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8410731A FR2567129B1 (fr) 1984-07-06 1984-07-06 Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
ES544927A0 ES544927A0 (es) 1986-07-16
ES8608530A1 true ES8608530A1 (es) 1986-07-16

Family

ID=9305857

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544927A Expired ES8608530A1 (es) 1984-07-06 1985-07-05 Procedimiento de obtencion de nuevos derivados de la oxaazo-fosforina

Country Status (15)

Country Link
US (1) US4605647A (es)
EP (1) EP0172059B1 (es)
JP (1) JPS6144894A (es)
AT (1) ATE33658T1 (es)
AU (1) AU571414B2 (es)
CA (1) CA1249818A (es)
DE (1) DE3562252D1 (es)
ES (1) ES8608530A1 (es)
FR (1) FR2567129B1 (es)
GR (1) GR851667B (es)
IE (1) IE58137B1 (es)
NZ (1) NZ212663A (es)
OA (1) OA08056A (es)
PT (1) PT80781B (es)
ZA (1) ZA855082B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254587A (en) * 1990-09-04 1993-10-19 Burzynski Stanislaw R Methods for treating AIDS
CN1443190A (zh) * 2000-07-18 2003-09-17 里奥制药有限公司 基质金属蛋白酶抑制剂
RU2004125160A (ru) 2002-01-18 2005-06-10 Лео Фарма А/С (Dk) Ингибиторы ммр

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54157580A (en) * 1978-05-29 1979-12-12 Otsuka Pharmaceut Co Ltd Optically active oxazaphosphorine derivative
DE3111428A1 (de) * 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
JPS5929696A (ja) * 1982-08-13 1984-02-16 Otsuka Pharmaceut Co Ltd ２−〔（ｎ−ニトロソ）−２−ハロゲノエチルアミノ〕−１，３，２−オキサアザホスホリナン−２−オキシド誘導体
JPS5931787A (ja) * 1982-08-13 1984-02-20 Otsuka Pharmaceut Co Ltd １，３，２−オキサアザホスホリナン−２−オキシド誘導体
FR2536075B1 (fr) * 1982-11-17 1985-07-05 Adir Nouveaux derives de la nitrosouree, leur procede de preparation et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
JPS6144894A (ja) 1986-03-04
PT80781B (pt) 1987-10-20
DE3562252D1 (en) 1988-05-26
EP0172059A1 (fr) 1986-02-19
PT80781A (fr) 1985-08-01
IE851698L (en) 1986-01-06
GR851667B (es) 1985-11-26
ES544927A0 (es) 1986-07-16
CA1249818A (fr) 1989-02-07
AU4464185A (en) 1986-01-09
ATE33658T1 (de) 1988-05-15
FR2567129A1 (fr) 1986-01-10
IE58137B1 (en) 1994-07-14
NZ212663A (en) 1988-06-30
US4605647A (en) 1986-08-12
JPH0250120B2 (es) 1990-11-01
OA08056A (fr) 1987-03-31
ZA855082B (en) 1986-02-26
EP0172059B1 (fr) 1988-04-20
FR2567129B1 (fr) 1986-12-05
AU571414B2 (en) 1988-04-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401