ES8703894A1 - Procedimiento para preparar peptidos liberadores de la hormona del crecimiento - Google Patents

Procedimiento para preparar peptidos liberadores de la hormona del crecimiento

Info

Publication number
ES8703894A1
ES8703894A1 ES550989A ES550989A ES8703894A1 ES 8703894 A1 ES8703894 A1 ES 8703894A1 ES 550989 A ES550989 A ES 550989A ES 550989 A ES550989 A ES 550989A ES 8703894 A1 ES8703894 A1 ES 8703894A1
Authority
ES
Spain
Prior art keywords
growth hormone
tyrosyl
procedure
hormone releasing
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550989A
Other languages
English (en)
Other versions
ES550989A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tulane University
Original Assignee
Tulane University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tulane University filed Critical Tulane University
Publication of ES550989A0 publication Critical patent/ES550989A0/es
Publication of ES8703894A1 publication Critical patent/ES8703894A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR PEPTIDOS LIBERADORES DE LA HORMONA DEL CRECIMIENTO. CONSISTE EN: UNIR UN AMINOACIDO C-TERMINAL PROTEGIDO A UNA RESINA EN PRESENCIA DE UN AGENTE DE ACOPLAMIENTO, LAVAR CON UN DISOLVENTE INERTE, DESPROTEGER EN PRESENCIA DE UN ACIDO, REPETIR ESTA SECUENCIA, Y DESUNIR EL PEPTIDO DE LA RESINA EN PRESENCIA DE UN ACIDO PARA PROPORCIONAR EL PEPTIDO DE FORMULA (I), (II) Y (III), DONDE R ES H O ALCANOILO DE C 1 A 6; R2 ES NR3R4 O OR3; A ES UN MIEMBRO ELEGIDO ENTRE TIROSILO, D-TIROSILO, HISTIDILO Y OTROS; C ES UN MIEMBRO ELEGIDO ENTRE ASPARTILO GLUTAMILO Y OTROS; Q ES SERILO O D-SERILO; X ES ASPARGINILO O D-ASPARGINILO; Y ES NORLEUCILO O METIONILO; Z ES TIROSILO O D-TIROSILI; U ES LISILO O ARGINILO; Y W ES LISILO O ARGINILO. SON UTILES COMO LIBERADORES DE LA HORMONA DEL CRECIMIENTO.
ES550989A 1985-01-17 1986-01-17 Procedimiento para preparar peptidos liberadores de la hormona del crecimiento Expired ES8703894A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69208285A 1985-01-17 1985-01-17

Publications (2)

Publication Number Publication Date
ES550989A0 ES550989A0 (es) 1987-03-16
ES8703894A1 true ES8703894A1 (es) 1987-03-16

Family

ID=24779183

Family Applications (1)

Application Number Title Priority Date Filing Date
ES550989A Expired ES8703894A1 (es) 1985-01-17 1986-01-17 Procedimiento para preparar peptidos liberadores de la hormona del crecimiento

Country Status (13)

Country Link
EP (1) EP0188214A3 (es)
JP (1) JPS61210099A (es)
AU (1) AU590738B2 (es)
CA (1) CA1271600A (es)
DK (1) DK171682B1 (es)
ES (1) ES8703894A1 (es)
FI (1) FI860200A7 (es)
IE (1) IE860131L (es)
IL (1) IL77534A (es)
NO (1) NO169173C (es)
NZ (1) NZ214792A (es)
PT (1) PT81845B (es)
ZA (1) ZA86338B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3742633A1 (de) * 1987-12-16 1989-06-29 Hoechst Ag Peptide mit beeinflussender wirkung auf die hypophyse von saeugern
US5565606A (en) * 1986-10-21 1996-10-15 Hoechst Aktiengesellschaft Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
IL86102A (en) * 1987-05-11 1994-04-12 Univ Tulane Alkylated growth hormone-releasing peptides and use thereof
US5002931A (en) * 1987-05-22 1991-03-26 The Salk Institute For Biological Studies GRF analogs VII
US4959352A (en) * 1987-09-18 1990-09-25 Hoffmann-La Roche Inc. Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
EP0307860B1 (en) * 1987-09-18 1994-06-08 F. Hoffmann-La Roche Ag Cyclic GRF-analogs
US5084442A (en) * 1988-09-06 1992-01-28 Hoffmann-La Roche Inc. Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
US5756458A (en) * 1989-06-16 1998-05-26 Pharmacia & Upjohn Company Stabilized potent GRF analogs
EP0544706A4 (en) * 1990-06-29 1993-10-13 Hoffmann-La Roche Inc. Histidine substituted growth hormone releasing factor analogs
ZA922746B (en) * 1991-04-26 1992-12-30 Lilly Co Eli Superactive grf analogs
US5550212A (en) * 1993-12-17 1996-08-27 The Administrators Of The Tulane Educational Fund Analogues of hGH-RH(1-29)NH2 having antagonistic activity
EP0820296A4 (en) * 1995-04-14 1999-06-30 Univ Tulane ANALOGS OF THE GROWTH HORMONE-RELEASING FACTOR
BRPI9608799B8 (pt) * 1995-05-26 2019-11-05 Theratechnologies Inc análogo pró-grf -corpo graxo quimérico com aumentada potência biológica, e, formulação farmacêutica.
BR0206919A (pt) 2001-02-02 2004-07-06 Conjuchem Inc Derivados de fator de liberação de hormÈnio de crescimento de longa duração

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517181A (en) * 1982-09-15 1985-05-14 The Salk Institute For Biological Studies Mammalian PGRF
NZ204456A (en) * 1982-06-16 1987-05-29 Salk Inst For Biological Studi Synthetic pancreatic growth-hormone releasing factor
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
US4518586A (en) * 1983-01-13 1985-05-21 The Salk Institute For Biological Studies GRF Analogs III
AU575843B2 (en) * 1983-08-10 1988-08-11 The Administrators Of The Tulane Eductional Fund Growth hormone releasing peptides
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
US4649131A (en) * 1984-09-24 1987-03-10 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs

Also Published As

Publication number Publication date
NZ214792A (en) 1989-01-27
AU5229986A (en) 1986-07-24
DK18086D0 (da) 1986-01-15
CA1271600A (en) 1990-07-10
DK171682B1 (da) 1997-03-10
FI860200A0 (fi) 1986-01-16
ZA86338B (en) 1987-08-26
ES550989A0 (es) 1987-03-16
IE860131L (en) 1986-07-17
EP0188214A2 (en) 1986-07-23
JPS61210099A (ja) 1986-09-18
NO169173B (no) 1992-02-10
DK18086A (da) 1986-07-18
PT81845A (en) 1986-02-01
FI860200A7 (fi) 1986-07-18
NO169173C (no) 1992-05-20
AU590738B2 (en) 1989-11-16
EP0188214A3 (en) 1989-05-24
PT81845B (pt) 1987-11-30
NO860149L (no) 1986-07-18
IL77534A (en) 1991-01-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040916