ES8706155A1 - Chemical compounds - Google Patents
Chemical compoundsInfo
- Publication number
- ES8706155A1 ES8706155A1 ES551550A ES551550A ES8706155A1 ES 8706155 A1 ES8706155 A1 ES 8706155A1 ES 551550 A ES551550 A ES 551550A ES 551550 A ES551550 A ES 551550A ES 8706155 A1 ES8706155 A1 ES 8706155A1
- Authority
- ES
- Spain
- Prior art keywords
- chemical compounds
- processes
- image
- quaternaryammonio
- iminoacetamido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 125000000656 azaniumyl group Chemical group [H][N+]([H])([H])[*] 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
7-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(substituted)-iminoacetamido]-3 -[3-(quaternaryammonio)-1 - propen-1-yl]-3-cephem-4-carboxylates of the formula < IMAGE > in which R<1> and R<2> are as defined herein and < IMAGE > is a quaternary ammonio group as defined herein, and salts, solvates, hydrates and esters thereof, are potent antibacterial agents. Processes for their preparation and intermediates in such processes are described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59794184A | 1984-04-09 | 1984-04-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES551550A0 ES551550A0 (en) | 1987-06-01 |
| ES8706155A1 true ES8706155A1 (en) | 1987-06-01 |
Family
ID=24393575
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542013A Expired ES8607318A1 (en) | 1984-04-09 | 1985-04-08 | Chemical compounds |
| ES551550A Expired ES8706155A1 (en) | 1984-04-09 | 1986-01-31 | Chemical compounds |
| ES551551A Expired ES8706694A1 (en) | 1984-04-09 | 1986-01-31 | Chemical compounds |
| ES557060A Expired ES8800949A1 (en) | 1984-04-09 | 1986-09-10 | Chemical compounds |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542013A Expired ES8607318A1 (en) | 1984-04-09 | 1985-04-08 | Chemical compounds |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES551551A Expired ES8706694A1 (en) | 1984-04-09 | 1986-01-31 | Chemical compounds |
| ES557060A Expired ES8800949A1 (en) | 1984-04-09 | 1986-09-10 | Chemical compounds |
Country Status (31)
| Country | Link |
|---|---|
| JP (4) | JPS615084A (en) |
| KR (1) | KR870002166B1 (en) |
| AR (1) | AR244694A1 (en) |
| AT (1) | AT388735B (en) |
| AU (2) | AU580990B2 (en) |
| BE (1) | BE902148A (en) |
| CA (3) | CA1276929C (en) |
| CH (1) | CH669197A5 (en) |
| DD (3) | DD236735A5 (en) |
| DE (1) | DE3512225A1 (en) |
| DK (1) | DK155985A (en) |
| ES (4) | ES8607318A1 (en) |
| FI (1) | FI84830C (en) |
| FR (1) | FR2563832B1 (en) |
| GB (3) | GB2157293B (en) |
| GR (1) | GR850883B (en) |
| HU (2) | HU193750B (en) |
| IE (2) | IE58408B1 (en) |
| IL (1) | IL74826A (en) |
| IT (1) | IT1190353B (en) |
| LU (1) | LU85840A1 (en) |
| MY (1) | MY101940A (en) |
| NL (1) | NL192925C (en) |
| NZ (1) | NZ211659A (en) |
| OA (1) | OA07985A (en) |
| PT (1) | PT80246B (en) |
| RU (1) | RU2056425C1 (en) |
| SE (4) | SE466205B (en) |
| SU (4) | SU1436882A3 (en) |
| YU (2) | YU46151B (en) |
| ZA (1) | ZA852236B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61145186A (en) * | 1984-12-20 | 1986-07-02 | Meiji Seika Kaisha Ltd | Novel cephem compound and preparation thereof |
| US4708955A (en) * | 1985-06-24 | 1987-11-24 | Bristol-Myers Company | 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof |
| ATE114657T1 (en) * | 1985-12-26 | 1994-12-15 | Eisai Co Ltd | CEPHALOSPORIN COMPOUNDS. |
| AU614723B2 (en) * | 1986-10-13 | 1991-09-12 | Eisai Co. Ltd. | 3-propenylcephem derivative |
| IL84128A (en) * | 1986-10-13 | 1992-12-01 | Eisai Co Ltd | 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them |
| JPH085897B2 (en) * | 1986-11-06 | 1996-01-24 | エーザイ株式会社 | 3-propenyl cephem derivative |
| FR2622585B1 (en) * | 1987-11-03 | 1991-04-19 | Roussel Uclaf | NOVEL CEPHALOSPORINS COMPRISING IN POSITION 3 A SUBSTITUTED VINYL RADICAL, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED |
| CA1339738C (en) * | 1988-03-16 | 1998-03-17 | Takashi Kamiya | Process for the preparation of cephem derivatives and entermediates therefor |
| JPH0699449B2 (en) * | 1988-03-16 | 1994-12-07 | エーザイ株式会社 | Synthetic intermediate of cephem derivative |
| FR2655042B1 (en) * | 1989-11-29 | 1994-01-21 | Adir Cie | NOVEL SUBSTITUTED BENZOTHIAZOLINONES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| FR2663332B1 (en) * | 1990-06-15 | 1997-11-07 | Roussel Uclaf | NOVEL CEPHALOSPORINS COMPRISING IN POSITION 3 A RADICAL PROPENYL SUBSTITUTED BY A QUATERNARY AMMONIUM, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED. |
| US5126336A (en) * | 1990-08-23 | 1992-06-30 | Bristol-Myers Squibb Company | Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof |
| AT396108B (en) * | 1991-08-21 | 1993-06-25 | Biochemie Gmbh | NEW PROCESS AND NEW INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF 7-AMINOCEPHALOSPORANIC ACID DERIVATIVES |
| JPH0741484A (en) * | 1993-07-29 | 1995-02-10 | Katayama Seiyakushiyo:Kk | Cephem compound and antimicrobial agent |
| EP0723966A4 (en) * | 1994-08-16 | 1997-01-29 | Meiji Seika Co | Novel cephem derivative |
| KR100414336B1 (en) | 1998-06-22 | 2004-01-07 | 바실리어 파마슈티카 아게 | Propenyl cephalosporin derivatives |
| EP1666483B1 (en) | 2003-09-09 | 2011-08-17 | Nippon Chemical Industrial Company Limited | Process for producing 3-chloromethyl-3-cephem derivative |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1342241A (en) * | 1970-01-23 | 1974-01-03 | Glaxo Lab Ltd | Cephalosporin compounds |
| US4390534A (en) * | 1978-12-29 | 1983-06-28 | Fujisawa Pharmaceutical Co., Ltd. | Cephem and cepham compounds |
| EP0025017A1 (en) * | 1979-08-28 | 1981-03-11 | Ciba-Geigy Ag | Polyazathia compounds, process for their preparation, pharmaceutical preparations containing such compounds and use of the latter |
| US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
| GR75644B (en) * | 1980-06-18 | 1984-08-02 | Fujisawa Pharmaceutical Co | |
| GR78245B (en) * | 1980-09-12 | 1984-09-26 | Ciba Geigy Ag | |
| US4521413A (en) * | 1981-09-14 | 1985-06-04 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| US4486586A (en) * | 1983-02-10 | 1984-12-04 | Bristol-Myers Company | Cephalosporin derivatives |
-
1985
- 1985-02-14 CA CA000474260A patent/CA1276929C/en not_active Expired - Lifetime
- 1985-03-25 ZA ZA852236A patent/ZA852236B/en unknown
- 1985-04-02 NZ NZ211659A patent/NZ211659A/en unknown
- 1985-04-02 AR AR85299945A patent/AR244694A1/en active
- 1985-04-03 DD DD85274832A patent/DD236735A5/en unknown
- 1985-04-03 DD DD85287524A patent/DD249024A5/en unknown
- 1985-04-03 DK DK155985A patent/DK155985A/en not_active Application Discontinuation
- 1985-04-03 SE SE8501680A patent/SE466205B/en not_active IP Right Cessation
- 1985-04-03 DE DE19853512225 patent/DE3512225A1/en active Granted
- 1985-04-04 PT PT80246A patent/PT80246B/en unknown
- 1985-04-04 AU AU40862/85A patent/AU580990B2/en not_active Expired
- 1985-04-04 CH CH1498/85A patent/CH669197A5/en not_active IP Right Cessation
- 1985-04-04 FI FI851379A patent/FI84830C/en not_active IP Right Cessation
- 1985-04-04 GB GB08508846A patent/GB2157293B/en not_active Expired
- 1985-04-04 OA OA58561A patent/OA07985A/en unknown
- 1985-04-04 IE IE86685A patent/IE58408B1/en not_active IP Right Cessation
- 1985-04-04 NL NL8501002A patent/NL192925C/en not_active IP Right Cessation
- 1985-04-05 FR FR8505281A patent/FR2563832B1/en not_active Expired
- 1985-04-05 AT AT0103985A patent/AT388735B/en not_active IP Right Cessation
- 1985-04-05 IT IT20267/85A patent/IT1190353B/en active
- 1985-04-05 IL IL74826A patent/IL74826A/en not_active IP Right Cessation
- 1985-04-05 LU LU85840A patent/LU85840A1/en unknown
- 1985-04-08 ES ES542013A patent/ES8607318A1/en not_active Expired
- 1985-04-08 GR GR850883A patent/GR850883B/el not_active IP Right Cessation
- 1985-04-08 RU SU853878102A patent/RU2056425C1/en active
- 1985-04-09 BE BE0/214810A patent/BE902148A/en not_active IP Right Cessation
- 1985-04-09 JP JP60075233A patent/JPS615084A/en active Granted
- 1985-04-09 KR KR1019850002383A patent/KR870002166B1/en not_active Expired
- 1985-04-09 YU YU60085A patent/YU46151B/en unknown
- 1985-04-09 HU HU851299A patent/HU193750B/en unknown
- 1985-04-09 HU HU87151A patent/HU204277B/en unknown
- 1985-11-12 JP JP60252138A patent/JPS61143390A/en active Granted
- 1985-11-12 JP JP60252140A patent/JPS61143387A/en active Granted
- 1985-11-12 JP JP60252139A patent/JPS61143391A/en active Granted
-
1986
- 1986-01-31 ES ES551550A patent/ES8706155A1/en not_active Expired
- 1986-01-31 ES ES551551A patent/ES8706694A1/en not_active Expired
- 1986-02-06 SU SU864020682A patent/SU1436882A3/en active
- 1986-02-06 SU SU864018257A patent/SU1375140A3/en active
- 1986-02-06 SU SU864019975A patent/SU1487814A3/en active
- 1986-02-06 SU SU864023036A patent/SU1367858A3/en active
- 1986-03-03 DD DD86287525A patent/DD251752A5/en unknown
- 1986-09-10 ES ES557060A patent/ES8800949A1/en not_active Expired
-
1987
- 1987-06-25 YU YU118987A patent/YU46213B/en unknown
- 1987-09-10 GB GB08721346A patent/GB2194789B/en not_active Expired
- 1987-09-10 GB GB08721347A patent/GB2194790B/en not_active Expired
- 1987-10-01 MY MYPI87002761A patent/MY101940A/en unknown
-
1988
- 1988-11-11 AU AU25041/88A patent/AU610278B2/en not_active Expired
-
1989
- 1989-04-04 IE IE121089A patent/IE58403B1/en not_active IP Right Cessation
- 1989-04-06 SE SE8901224A patent/SE470259B/en not_active IP Right Cessation
- 1989-04-06 SE SE8901225A patent/SE505256C2/en not_active IP Right Cessation
- 1989-04-06 SE SE8901226A patent/SE470260B/en not_active IP Right Cessation
-
1991
- 1991-08-12 CA CA000616143A patent/CA1340638C/en not_active Expired - Fee Related
- 1991-08-21 CA CA000616144A patent/CA1340672C/en not_active Expired - Fee Related
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
| ES8706694A1 (en) | Chemical compounds | |
| LU90159I2 (en) | Difloxacin optionally in the form of a pharmaceutical salt or ester | |
| GB2022090A (en) | 7-[2-(2-amino-4-thiazolyl)-2- methoxyimino-acetamido]-3- heterocyclyl(thiomethyl)-cephems | |
| GR1000462B (en) | 7-[2-(s-amino1,2,4-thiadiazol-3yl)-2-(substituted-iminoacetamido]-3-[3-(quaternaryammonio)-1-propen-1-y]-3-cephem-4-carboxy-lates of the formula | |
| DE3167258D1 (en) | Synisomer cephalosporin compounds and processes for their preparation | |
| ES8706144A1 (en) | Novel 1,8-naphthyridine derivatives and processes for preparation thereof. | |
| ZA835411B (en) | Novel cephalosporin compounds and preparation thereof | |
| SE8601825L (en) | 7-AMINO-3-PROPENYLECEPHALOSPORANIC ACID AND ESTERS THEREOF | |
| GR3030506T3 (en) | 1-azaadamantane derivatives as 5-ht agonists or antagonists. | |
| JPS6485A (en) | Novel cephalosporin derivative | |
| GR82437B (en) | ||
| GR3015422T3 (en) | Thiadiazolylacetamide cephem derivatives. | |
| JPS56142283A (en) | Penem-3-carboxylic acid derivative and its preparation | |
| JPS6425783A (en) | Novel cephalosporin compound and antibacterial material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20070326 |