ES8706703A1 - Procedimiento de hemisintesis de vincristina - Google Patents

Procedimiento de hemisintesis de vincristina

Info

Publication number
ES8706703A1
ES8706703A1 ES555499A ES555499A ES8706703A1 ES 8706703 A1 ES8706703 A1 ES 8706703A1 ES 555499 A ES555499 A ES 555499A ES 555499 A ES555499 A ES 555499A ES 8706703 A1 ES8706703 A1 ES 8706703A1
Authority
ES
Spain
Prior art keywords
vincristine
preparation
salts
present
semisynthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555499A
Other languages
English (en)
Other versions
ES555499A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of ES555499A0 publication Critical patent/ES555499A0/es
Publication of ES8706703A1 publication Critical patent/ES8706703A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

PROCEDIMIENTO PARA LA HEMISINTESIS DE VINCRISTINA. CONSISTE EN OXIDAR LA VINBLASTINA O SUS SALES, CON ACIDO CROMICO O CON SUS SALES, A BAJA TEMPERATURA Y EN PRESENCIA DE ACETATO DE ETILO. EL MEDIO DE REACCION UTILIZADO HA DE CONTENER ACIDO ACETICO. LA VINCRISTINA BASE LIBERADA DESPUES DE LA NEUTRALIZACION DEL MEDIO DE REACCION, SE OBTIENEN DIRECTAMENTE POR DECANTACION DEL ACETATO DE ETILO, Y POSTERIORMENTE LA VINCRISTINA OBTENIDA EN ESTADO BRUTO SE PURIFICA POR CRISTALIZACION EN METANOL. DE APLICACION EN EL TRATAMIENTO DEL CANCER.
ES555499A 1985-06-03 1986-05-30 Procedimiento de hemisintesis de vincristina Expired ES8706703A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8508333A FR2582651B1 (fr) 1985-06-03 1985-06-03 Procede de preparation de vincristine

Publications (2)

Publication Number Publication Date
ES555499A0 ES555499A0 (es) 1987-07-01
ES8706703A1 true ES8706703A1 (es) 1987-07-01

Family

ID=9319808

Family Applications (1)

Application Number Title Priority Date Filing Date
ES555499A Expired ES8706703A1 (es) 1985-06-03 1986-05-30 Procedimiento de hemisintesis de vincristina

Country Status (8)

Country Link
US (1) US4767855A (es)
EP (1) EP0207831B1 (es)
JP (1) JPH07110866B2 (es)
AT (1) ATE61059T1 (es)
CA (1) CA1260932A (es)
DE (1) DE3677646D1 (es)
ES (1) ES8706703A1 (es)
FR (1) FR2582651B1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003513756A (ja) * 1999-11-12 2003-04-15 アンジオテック ファーマシューティカルズ，インコーポレイテッド 放射性治療と細胞周期インヒビターとの組合せの組成物
EP2181704B1 (en) 2002-12-30 2015-05-06 Angiotech International Ag Drug delivery from rapid gelling polymer composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899493A (en) * 1972-12-29 1975-08-12 Richter Gedeon Vegyeszet Chromic acid oxidation of vinblastine sulfate to form vincristine
GB1551054A (en) * 1976-03-04 1979-08-22 Atta Ur Rahman Syntheses of vinblastine vincristine and vinrosidine
US4375432A (en) * 1981-05-12 1983-03-01 Eli Lilly And Company Method of preparing vincristine
LU84640A1 (fr) * 1983-02-10 1984-11-08 Onmichem S A Nouveau procede d'obtention de la vincristine et du sulfate de vincristine
HU190219B (en) * 1984-01-06 1986-08-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing in 3",7'-position cyclized dimer-cinca-alkaloid-derivatives

Also Published As

Publication number Publication date
EP0207831A1 (fr) 1987-01-07
EP0207831B1 (fr) 1991-02-27
DE3677646D1 (de) 1991-04-04
ES555499A0 (es) 1987-07-01
FR2582651A1 (fr) 1986-12-05
ATE61059T1 (de) 1991-03-15
CA1260932A (fr) 1989-09-26
FR2582651B1 (fr) 1987-08-28
US4767855A (en) 1988-08-30
JPS61293989A (ja) 1986-12-24
JPH07110866B2 (ja) 1995-11-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070122