ATE61059T1 - Verfahren zur herstellung von vincristin. - Google Patents

Verfahren zur herstellung von vincristin.

Info

Publication number: ATE61059T1
Authority: AT; Austria
Prior art keywords: vincristin; production; salts; present; vincristine
Prior art date: 1985-06-03

Application number

AT86401179T

Other languages

English (en)

Inventor

Roger Tarroux

Jacques Fahy

Philippe Hatinguais

Original Assignee

Pf Medicament

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-03

Filing date

1986-06-03

Publication date

1991-03-15

1986-06-03 Application filed by Pf Medicament filed Critical Pf Medicament

1991-03-15 Application granted granted Critical

1991-03-15 Publication of ATE61059T1 publication Critical patent/ATE61059T1/de

Links

229960004528 vincristine Drugs 0.000 title abstract 3
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title abstract 3
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title abstract 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 2
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 1
KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 abstract 1
AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
229960003048 vinblastine Drugs 0.000 abstract 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Compounds Of Unknown Constitution (AREA)

AT86401179T 1985-06-03 1986-06-03 Verfahren zur herstellung von vincristin. ATE61059T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8508333A FR2582651B1 (fr)	1985-06-03	1985-06-03	Procede de preparation de vincristine
EP86401179A EP0207831B1 (de)	1985-06-03	1986-06-03	Verfahren zur Herstellung von Vincristin

Publications (1)

Publication Number	Publication Date
ATE61059T1 true ATE61059T1 (de)	1991-03-15

Family

ID=9319808

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86401179T ATE61059T1 (de)	1985-06-03	1986-06-03	Verfahren zur herstellung von vincristin.

Country Status (8)

Country	Link
US (1)	US4767855A (de)
EP (1)	EP0207831B1 (de)
JP (1)	JPH07110866B2 (de)
AT (1)	ATE61059T1 (de)
CA (1)	CA1260932A (de)
DE (1)	DE3677646D1 (de)
ES (1)	ES8706703A1 (de)
FR (1)	FR2582651B1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2388844A1 (en) *	1999-11-12	2001-05-25	Angiotech Pharmaceuticals, Inc.	Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
AU2003300076C1 (en)	2002-12-30	2010-03-04	Angiotech International Ag	Drug delivery from rapid gelling polymer composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3899493A (en) *	1972-12-29	1975-08-12	Richter Gedeon Vegyeszet	Chromic acid oxidation of vinblastine sulfate to form vincristine
GB1551054A (en) *	1976-03-04	1979-08-22	Atta Ur Rahman	Syntheses of vinblastine vincristine and vinrosidine
US4375432A (en) *	1981-05-12	1983-03-01	Eli Lilly And Company	Method of preparing vincristine
LU84640A1 (fr) *	1983-02-10	1984-11-08	Onmichem S A	Nouveau procede d'obtention de la vincristine et du sulfate de vincristine
HU190219B (en) *	1984-01-06	1986-08-28	Richter Gedeon Vegyeszeti Gyar Rt,Hu	Process for preparing in 3",7'-position cyclized dimer-cinca-alkaloid-derivatives

1985
- 1985-06-03 FR FR8508333A patent/FR2582651B1/fr not_active Expired
1986
- 1986-05-30 ES ES555499A patent/ES8706703A1/es not_active Expired
- 1986-06-02 US US06/869,433 patent/US4767855A/en not_active Expired - Lifetime
- 1986-06-02 CA CA000510611A patent/CA1260932A/fr not_active Expired
- 1986-06-03 JP JP61129016A patent/JPH07110866B2/ja not_active Expired - Lifetime
- 1986-06-03 EP EP86401179A patent/EP0207831B1/de not_active Expired - Lifetime
- 1986-06-03 AT AT86401179T patent/ATE61059T1/de not_active IP Right Cessation
- 1986-06-03 DE DE8686401179T patent/DE3677646D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FR2582651B1 (fr)	1987-08-28
DE3677646D1 (de)	1991-04-04
ES8706703A1 (es)	1987-07-01
EP0207831B1 (de)	1991-02-27
US4767855A (en)	1988-08-30
CA1260932A (fr)	1989-09-26
JPH07110866B2 (ja)	1995-11-29
ES555499A0 (es)	1987-07-01
EP0207831A1 (de)	1987-01-07
JPS61293989A (ja)	1986-12-24
FR2582651A1 (fr)	1986-12-05

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Legal Events

Date	Code	Title	Description
1991-08-15	UEP	Publication of translation of european patent specification
2006-09-15	EELA	Cancelled due to lapse of time