ES8708241A1 - Un procedimiento para la preparacion de nuevos compuestos poliprenilicos - Google Patents

Un procedimiento para la preparacion de nuevos compuestos poliprenilicos

Info

Publication number
ES8708241A1
ES8708241A1 ES557246A ES557246A ES8708241A1 ES 8708241 A1 ES8708241 A1 ES 8708241A1 ES 557246 A ES557246 A ES 557246A ES 557246 A ES557246 A ES 557246A ES 8708241 A1 ES8708241 A1 ES 8708241A1
Authority
ES
Spain
Prior art keywords
preparation
polyprenilic
compounds
procedure
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557246A
Other languages
English (en)
Other versions
ES557246A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ES557246A0 publication Critical patent/ES557246A0/es
Publication of ES8708241A1 publication Critical patent/ES8708241A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Steroid Compounds (AREA)
  • Polyethers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS COMPUESTOS POLIPRENILICOS. COMPRENDE: A) HACER REACCIONAR (POR REACCION DE GRIGNARD) EL COMPUESTO DE FORMULA (II) CON DIOXIDO DE CARBONO, A UNA TEMPERATURA ENTRE -70GC Y LA AMBIENTE, PARA FORMAR EL ACIDO DE FORMULA (I); B) FORMAR LA SAL POTASICA, SODICA O ALUMINICA, PARA SER FARMACEUTICAMENTE ACEPTABLE. SIENDO: A Y B E Y Y Z, H O ENLACE SENCILLO CUANDO ESTAN UNIDOS; Y N, 0, 1 O 2. SE UTILIZAN COMO ANTIHIPERCOLESTEROLEMICOS Y ANTIARTERIOESCLEROTICOS. *FORMULA*
ES557246A 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos Expired ES8708241A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60050544A JPH0629218B2 (ja) 1985-03-15 1985-03-15 ポリプレニル系化合物

Publications (2)

Publication Number Publication Date
ES557246A0 ES557246A0 (es) 1987-10-01
ES8708241A1 true ES8708241A1 (es) 1987-10-01

Family

ID=12861949

Family Applications (7)

Application Number Title Priority Date Filing Date
ES552948A Expired ES8800124A1 (es) 1985-03-15 1986-03-12 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos.
ES557246A Expired ES8708241A1 (es) 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos
ES557245A Expired ES8802064A1 (es) 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos
ES557244A Expired ES8802063A1 (es) 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos
ES557247A Expired ES8708239A1 (es) 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos
ES557243A Expired ES8708240A1 (es) 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos
ES557242A Expired ES8801682A1 (es) 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES552948A Expired ES8800124A1 (es) 1985-03-15 1986-03-12 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos.

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES557245A Expired ES8802064A1 (es) 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos
ES557244A Expired ES8802063A1 (es) 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos
ES557247A Expired ES8708239A1 (es) 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos
ES557243A Expired ES8708240A1 (es) 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos
ES557242A Expired ES8801682A1 (es) 1985-03-15 1986-12-04 Un procedimiento para la preparacion de nuevos compuestos poliprenilicos

Country Status (18)

Country Link
US (2) US4788330A (es)
EP (1) EP0194693B1 (es)
JP (1) JPH0629218B2 (es)
KR (1) KR920000877B1 (es)
AT (1) ATE44950T1 (es)
AU (1) AU596577B2 (es)
CA (1) CA1264331A (es)
DE (1) DE3664631D1 (es)
DK (1) DK168432B1 (es)
ES (7) ES8800124A1 (es)
FI (1) FI91392C (es)
GR (1) GR860568B (es)
HU (1) HU197294B (es)
IE (1) IE58413B1 (es)
NZ (1) NZ215480A (es)
PH (1) PH22339A (es)
PT (1) PT82202B (es)
ZA (1) ZA861645B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4714078A (en) * 1984-12-03 1987-12-22 Paluch Bernard R Insert for heated humidifier used in respiratory therapy
US4823787A (en) * 1987-07-09 1989-04-25 Carmeli Adahan Portable ventilator apparatus
US4883821A (en) * 1988-04-13 1989-11-28 Eisai Co., Ltd. Agent for treating hyperuricemia
CA2407421C (en) * 2000-04-24 2009-11-03 Nikken Chemicals Co., Ltd. Activators of peroxisome proliferator-activated receptors
EP1506778B1 (en) * 2002-05-17 2014-03-26 Kowa Company, Ltd. TGF-a EXPRESSION INHIBITORS
US7314643B2 (en) * 2002-08-20 2008-01-01 Nikken Chemicals Co., Ltd. Soft capsule preparation
JP4886506B2 (ja) * 2004-02-25 2012-02-29 国立大学法人 東京大学 転写因子ｋｌｆ５の活性化抑制作用を有する医薬
FR2882359A1 (fr) * 2005-02-24 2006-08-25 Negma Lerads Soc Par Actions S Derives activateurs de ppar, procede de preparation et application en therapeutique
AU2023437235A1 (en) * 2023-03-14 2025-10-30 Suzhou Haiyi Biomedical Technology Co., Ltd. 1,4-polyisoprene dispersion system, pharmaceutical active ingredient and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046305A (en) * 1959-09-24 1962-07-24 Pure Oil Co Process for the production of paralkyl-phenol and para-alkyl-benzoic acid
US3385887A (en) * 1961-02-02 1968-05-28 Boots Pure Drug Co Ltd 4-isobutylphenylacetic acid
US3764621A (en) 1967-04-20 1973-10-09 Du Pont Certain substituted methylbenzoic acids and substituted methycyclohexane carboxylic acids
FR2268791A1 (en) * 1974-04-25 1975-11-21 Nobel Hoechst Chimie Para-alkyl benzoic acid alkanolamine condensate - useful as water-soluble or dispersable corrosion inhibitors for ferrous metals
JPS58225039A (ja) * 1982-06-22 1983-12-27 Eisai Co Ltd ポリプレニル系化合物
JPS59101448A (ja) * 1982-11-30 1984-06-12 Eisai Co Ltd ポリプレニルカルボン酸アミドおよびその製造方法ならびにそれを含有する医薬

Also Published As

Publication number Publication date
ES8802064A1 (es) 1988-03-16
ATE44950T1 (de) 1989-08-15
ES8708240A1 (es) 1987-10-01
ES557243A0 (es) 1987-10-01
DK116386A (da) 1986-09-16
ES557242A0 (es) 1988-02-16
ES8800124A1 (es) 1987-11-01
DE3664631D1 (en) 1989-08-31
EP0194693A1 (en) 1986-09-17
DK116386D0 (da) 1986-03-13
AU596577B2 (en) 1990-05-10
PT82202B (pt) 1988-02-17
JPH0629218B2 (ja) 1994-04-20
GR860568B (en) 1986-07-10
NZ215480A (en) 1989-07-27
DK168432B1 (da) 1994-03-28
ES8802063A1 (es) 1988-03-16
ES8801682A1 (es) 1988-02-16
PH22339A (en) 1988-08-12
KR860007191A (ko) 1986-10-08
ZA861645B (en) 1986-10-29
JPS61210050A (ja) 1986-09-18
IE58413B1 (en) 1993-09-22
FI860816A7 (fi) 1986-09-16
ES557247A0 (es) 1987-10-01
EP0194693B1 (en) 1989-07-26
ES557246A0 (es) 1987-10-01
FI91392C (fi) 1994-06-27
AU5448786A (en) 1986-09-18
KR920000877B1 (ko) 1992-01-30
ES557245A0 (es) 1988-03-16
ES557244A0 (es) 1988-03-16
HU197294B (en) 1989-03-28
PT82202A (en) 1986-04-01
FI91392B (fi) 1994-03-15
IE860568L (en) 1986-09-15
ES552948A0 (es) 1987-11-01
US4883916A (en) 1989-11-28
CA1264331A (en) 1990-01-09
HUT40066A (en) 1986-11-28
US4788330A (en) 1988-11-29
ES8708239A1 (es) 1987-10-01
FI860816A0 (fi) 1986-02-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601