ES8800221A1 - Un procedimiento para preparar derivados de 1,6-naftiridin-2 (1h)-ona - Google Patents

Un procedimiento para preparar derivados de 1,6-naftiridin-2 (1h)-ona

Info

Publication number
ES8800221A1
ES8800221A1 ES551258A ES551258A ES8800221A1 ES 8800221 A1 ES8800221 A1 ES 8800221A1 ES 551258 A ES551258 A ES 551258A ES 551258 A ES551258 A ES 551258A ES 8800221 A1 ES8800221 A1 ES 8800221A1
Authority
ES
Spain
Prior art keywords
preparation
naphthyridin
ones
formula
pyridinecarbonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551258A
Other languages
English (en)
Other versions
ES551258A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES8800221A1 publication Critical patent/ES8800221A1/es
Publication of ES551258A0 publication Critical patent/ES551258A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 1,6-NAFTIRIDIN-2-(1H)-ONA. CONSISTE EN HACER REACCIONAR AL 5-BROMO (O CLORO)-7-R''-1,6-NAFTIRIDIN-2(1H)-ONA DE FORMULA (II) CON EL COMPUESTO 1H-(N AROMATICO DE 5 MIEMBROS)-HETERILO DE FORMULA (III), EN DIMETILFORMAMIDA, EN PRESENCIA DE UN ACEPTOR DE ACIDO COMO CARBONATO DE POTASIO ANHIDRO Y ENTRE 125 Y 225GC, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R, H, HALO O ALQUILO INFERIOR; R'', H O METILO; R1, H, ALQUILO INFERIOR, HIDROXIMETILO Y OTROS; X, CL O BR; Y Z, C-HALO, N,C-HIDROXIMETILO Y OTROS. SE UTILIZAN COMO CARDIOTONICOS. *FORMULA* E
ES551258A 1985-01-28 1986-01-27 Un procedimiento para preparar derivados de 1,6-naftiridin-2 (1h)-ona Expired ES8800221A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69560385A 1985-01-28 1985-01-28
US76590085A 1985-08-14 1985-08-14
US81104085A 1985-12-19 1985-12-19

Publications (2)

Publication Number Publication Date
ES8800221A1 true ES8800221A1 (es) 1987-11-01
ES551258A0 ES551258A0 (es) 1987-11-01

Family

ID=27418622

Family Applications (1)

Application Number Title Priority Date Filing Date
ES551258A Expired ES8800221A1 (es) 1985-01-28 1986-01-27 Un procedimiento para preparar derivados de 1,6-naftiridin-2 (1h)-ona

Country Status (12)

Country Link
EP (1) EP0189853A3 (es)
KR (1) KR870006046A (es)
AU (1) AU590870B2 (es)
DK (1) DK32086A (es)
ES (1) ES8800221A1 (es)
FI (1) FI860305A7 (es)
GR (1) GR860180B (es)
IL (1) IL77670A (es)
NO (1) NO860230L (es)
NZ (1) NZ214837A (es)
PH (1) PH22347A (es)
PT (1) PT81894B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567186A (en) * 1985-01-14 1986-01-28 Sterling Drug Inc. 5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor
PL378111A1 (pl) * 2003-02-14 2006-03-06 Smithkline Beecham Corporation Nowe związki

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415580A (en) * 1982-08-02 1983-11-15 Sterling Drug Inc. Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same
PT79699B (en) * 1983-12-22 1986-12-10 Pfizer Process for preparing quinolone inotropic agents
US4560691A (en) * 1984-07-13 1985-12-24 Sterling Drug Inc. 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation

Also Published As

Publication number Publication date
EP0189853A2 (en) 1986-08-06
AU5244786A (en) 1986-07-31
KR870006046A (ko) 1987-07-08
PH22347A (en) 1988-08-12
DK32086A (da) 1986-07-29
PT81894B (en) 1987-05-05
GR860180B (en) 1986-05-29
IL77670A (en) 1989-05-15
ES551258A0 (es) 1987-11-01
DK32086D0 (da) 1986-01-22
PT81894A (en) 1986-02-01
FI860305A0 (fi) 1986-01-22
NO860230L (no) 1986-07-29
EP0189853A3 (en) 1987-12-16
FI860305A7 (fi) 1986-07-29
NZ214837A (en) 1988-10-28
AU590870B2 (en) 1989-11-23

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