ES8800944A1 - Procedimiento para preparar derivados de saframicina a. - Google Patents

Procedimiento para preparar derivados de saframicina a.

Info

Publication number
ES8800944A1
ES8800944A1 ES555459A ES555459A ES8800944A1 ES 8800944 A1 ES8800944 A1 ES 8800944A1 ES 555459 A ES555459 A ES 555459A ES 555459 A ES555459 A ES 555459A ES 8800944 A1 ES8800944 A1 ES 8800944A1
Authority
ES
Spain
Prior art keywords
procedure
saframicin
preparation
saframicina
cultivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555459A
Other languages
English (en)
Other versions
ES555459A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES555459A0 publication Critical patent/ES555459A0/es
Publication of ES8800944A1 publication Critical patent/ES8800944A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/56—Streptomyces lavendulae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/899—Streptomyces lavendulae

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE SAFRAMICINA A, DE FORMULA GENERAL (I), Y DE SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES, TALES COMO ACIDOS NO TOXICOS Y FISIOLOGICAMENTE BIEN TOLERADOS. CONSISTE EN PREPARAR UN CULTIVO POR INOCULACION DE UN MEDIO DE CULTIVO QUE CONTIENE FUENTES DE CARBONO Y NITROGENO Y TRAZAS DE ELEMENTOS ESENCIALES, CON UNA CEPA DEL GENERO STREPTOMYCES, QUE ES CAPAZ DE PRODUCIR SAFRAMICINA A; Y EN CULTIVAR A UNA TEMPERATURA COMPRENDIDA ENTRE 25 Y C35 GRADOS, Y A UN PH COMPRENDIDO ENTRE 4 Y C7,5, EN CONDICIONES AEROBICAS. DE APLICACION EN LA PREPARACION DE ANTIBIOTICOS MEDIANTE FERMENTACION, CON ACTIVIDAD CONTRA TUMORES TRANSPLANTABLES.
ES555459A 1984-08-30 1986-05-29 Procedimiento para preparar derivados de saframicina a. Expired ES8800944A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59179292A JPS6158593A (ja) 1984-08-30 1984-08-30 新規サフラマイシンａ誘導体およびその製造法

Publications (2)

Publication Number Publication Date
ES555459A0 ES555459A0 (es) 1987-12-01
ES8800944A1 true ES8800944A1 (es) 1987-12-01

Family

ID=16063271

Family Applications (2)

Application Number Title Priority Date Filing Date
ES546574A Expired ES8701178A1 (es) 1984-08-30 1985-08-30 Procedimiento para preparar derivados de saframicina a
ES555459A Expired ES8800944A1 (es) 1984-08-30 1986-05-29 Procedimiento para preparar derivados de saframicina a.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES546574A Expired ES8701178A1 (es) 1984-08-30 1985-08-30 Procedimiento para preparar derivados de saframicina a

Country Status (14)

Country Link
US (1) US4837149A (es)
EP (1) EP0173649A3 (es)
JP (1) JPS6158593A (es)
KR (1) KR860002575A (es)
DD (1) DD239611A5 (es)
DK (1) DK391885A (es)
ES (2) ES8701178A1 (es)
FI (1) FI853282A7 (es)
GR (1) GR852097B (es)
HU (1) HUT41071A (es)
IL (1) IL76242A0 (es)
NO (1) NO853396L (es)
PT (1) PT81037B (es)
ZA (1) ZA856598B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0262085A1 (de) * 1986-08-15 1988-03-30 Gesellschaft für Biotechnologische Forschung mbH (GBF) Antibiotika aus Myxococcus
ES2135990B1 (es) 1995-07-13 2000-05-01 Klein Iberica Estructura para el montaje de puertas correderas.
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
JP2004529074A (ja) 2000-11-03 2004-09-24 プレジデント アンド フェロウズ オブ ハーバード カレッジ サフラマイシン、そのアナログ、およびその使用
US6964804B2 (en) * 2001-02-14 2005-11-15 Shipley Company, L.L.C. Micromachined structures made by combined wet and dry etching
US7183054B2 (en) 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
KR100712667B1 (ko) * 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5937952B2 (ja) * 1977-09-12 1984-09-12 正 新井 抗生物質サフラマイシンａ，ｂ，ｃ，ｄ，ｅおよびその製造法
JPS56135486A (en) * 1980-03-26 1981-10-22 Tadashi Arai Antibiotic saframycin s and its preparative method

Also Published As

Publication number Publication date
FI853282L (fi) 1986-03-01
EP0173649A3 (en) 1987-08-12
ES8701178A1 (es) 1986-11-16
IL76242A0 (en) 1986-01-31
PT81037B (en) 1987-06-24
GR852097B (es) 1986-01-02
PT81037A (en) 1985-09-01
ZA856598B (en) 1986-04-30
JPS6158593A (ja) 1986-03-25
DD239611A5 (de) 1986-10-01
ES555459A0 (es) 1987-12-01
US4837149A (en) 1989-06-06
EP0173649A2 (en) 1986-03-05
ES546574A0 (es) 1986-11-16
DK391885A (da) 1986-03-01
FI853282A0 (fi) 1985-08-28
KR860002575A (ko) 1986-04-26
DK391885D0 (da) 1985-08-29
NO853396L (no) 1986-03-03
HUT41071A (en) 1987-03-30
FI853282A7 (fi) 1986-03-01

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