ES8704148A1 - Un procedimiento para preparar derivados de antraciclina - Google Patents

Un procedimiento para preparar derivados de antraciclina

Info

Publication number
ES8704148A1
ES8704148A1 ES544745A ES544745A ES8704148A1 ES 8704148 A1 ES8704148 A1 ES 8704148A1 ES 544745 A ES544745 A ES 544745A ES 544745 A ES544745 A ES 544745A ES 8704148 A1 ES8704148 A1 ES 8704148A1
Authority
ES
Spain
Prior art keywords
anthracicline
derivatives
procedure
general formula
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544745A
Other languages
English (en)
Other versions
ES544745A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES544745A0 publication Critical patent/ES544745A0/es
Publication of ES8704148A1 publication Critical patent/ES8704148A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ANTRACICLINA, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDO FARACEUTICAMENTE ACEPTABLES. CONSISTE EN CULTIVAR UNA CEPA DEL GENERO STREPTOMYCES CAPAZ DE PRODUCIR COMPUESTOS DE ANTRACICLINA EN UN MEDIO ADECUADO DE CULTIVO BAJO CONDICIONES AEROBIAS, Y EN RECUPERAR SUBSIGUIENTEMENTE LOS COMPUESTOS DE FORMULA GENERAL (I) OBTENIDOS EN EL MEDIO DE CULTIVO. DICHO MEDIO DE CULTIVO COMPRENDE FUENTES NUTRITIVAS DE CARBONO, FUENTES DE NITROGENO Y, OPCIONALMENTE, SALES INORGANICAS O AGENTES ANTIESPUMANTES, A UNA TEMPERATURA COMPRENDIDA ENTRE 20 Y 35 GRADOS. DE APLICACION COMO ANTIBIOTICOS PARA EL CONTROL DEL CANCER.
ES544745A 1984-07-03 1985-07-01 Un procedimiento para preparar derivados de antraciclina Expired ES8704148A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59137486A JPS6117597A (ja) 1984-07-03 1984-07-03 アントラサイクリン化合物

Publications (2)

Publication Number Publication Date
ES544745A0 ES544745A0 (es) 1987-03-16
ES8704148A1 true ES8704148A1 (es) 1987-03-16

Family

ID=15199762

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544745A Expired ES8704148A1 (es) 1984-07-03 1985-07-01 Un procedimiento para preparar derivados de antraciclina

Country Status (9)

Country Link
EP (1) EP0167935B1 (es)
JP (1) JPS6117597A (es)
AT (1) ATE45953T1 (es)
DE (1) DE3572668D1 (es)
DK (1) DK165747B (es)
ES (1) ES8704148A1 (es)
GR (1) GR851608B (es)
HU (1) HU194942B (es)
ZA (1) ZA854979B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10029433A1 (de) * 2000-06-15 2001-12-20 Bioleads Gmbh Rhodomycinon-Derivate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
DE3323025A1 (de) * 1983-06-25 1985-01-10 Hoechst Ag, 6230 Frankfurt Anthracyclin-derivate, ein mikrobiologisches verfahren zu ihrer herstellung und ihre verwendung als cytostatika
DE3325957A1 (de) * 1983-07-19 1985-02-07 Hoechst Ag, 6230 Frankfurt Anthracyclin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als cytostatika

Also Published As

Publication number Publication date
ATE45953T1 (de) 1989-09-15
ES544745A0 (es) 1987-03-16
GR851608B (es) 1985-11-26
EP0167935A3 (en) 1986-10-08
DK301685D0 (da) 1985-07-02
DK165747B (da) 1993-01-11
DK301685A (da) 1986-01-04
EP0167935B1 (en) 1989-08-30
JPS6117597A (ja) 1986-01-25
DE3572668D1 (en) 1989-10-05
HUT41441A (en) 1987-04-28
HU194942B (en) 1988-03-28
ZA854979B (en) 1986-02-26
EP0167935A2 (en) 1986-01-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301