ES8801220A1 - Procedimiento para preparar 5-pirimidin-carboxamidas sustituidas con actividadd anti-leucemia. - Google Patents

Procedimiento para preparar 5-pirimidin-carboxamidas sustituidas con actividadd anti-leucemia.

Info

Publication number
ES8801220A1
ES8801220A1 ES557684A ES557684A ES8801220A1 ES 8801220 A1 ES8801220 A1 ES 8801220A1 ES 557684 A ES557684 A ES 557684A ES 557684 A ES557684 A ES 557684A ES 8801220 A1 ES8801220 A1 ES 8801220A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
thienylmethyl
naphthylmethyl
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557684A
Other languages
English (en)
Other versions
ES557684A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Uniroyal Chemical Co Inc
Original Assignee
Uniroyal Chemical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniroyal Chemical Co Inc filed Critical Uniroyal Chemical Co Inc
Publication of ES8801220A1 publication Critical patent/ES8801220A1/es
Publication of ES557684A0 publication Critical patent/ES557684A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 5-PIRIMIDINCARBOXAMIDAS, Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I). CONSISTE EN LA REACCION DE UNA O-ALQUILSEUDOREA CON UN DIESTER DE ACIDO 2-AROILAMINOPROPANODIOICO SUSTITUIDO PARA OBTENER EL COMPUESTO DE FORMULA (I) EN LA QUE R1 REPRESENTA HIDROGENO O ALCOXI C1-4, R3 Y R4 PUEDEN SER HIDROGENO O FLUOR Y R2 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. LA REACCION SE EFECTUA SIGUIENDO METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTI-LEUCEMICA.
ES557684A 1985-04-22 1987-08-19 Procedimiento para preparar 5-pirimidin-carboxamidas sustituidas con actividadd anti-leucemia. Expired ES8801220A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/725,736 US4636508A (en) 1985-04-22 1985-04-22 5-pyrimidinecarboxyamides and treatment of leukemia therewith

Publications (2)

Publication Number Publication Date
ES8801220A1 true ES8801220A1 (es) 1988-01-01
ES557684A0 ES557684A0 (es) 1988-01-01

Family

ID=24915762

Family Applications (3)

Application Number Title Priority Date Filing Date
ES554245A Expired ES8800671A1 (es) 1985-04-22 1986-04-22 Procedimiento para preparar 5-pirimidin-carboxamidas sustituidas con actividad anti-leucemia
ES557684A Expired ES8801220A1 (es) 1985-04-22 1987-08-19 Procedimiento para preparar 5-pirimidin-carboxamidas sustituidas con actividadd anti-leucemia.
ES557683A Expired ES8801219A1 (es) 1985-04-22 1987-08-19 Procedimiento para preparar 5-pririmidin-carboxamidas sustituidas con actividad anti-leucemia.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES554245A Expired ES8800671A1 (es) 1985-04-22 1986-04-22 Procedimiento para preparar 5-pirimidin-carboxamidas sustituidas con actividad anti-leucemia

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557683A Expired ES8801219A1 (es) 1985-04-22 1987-08-19 Procedimiento para preparar 5-pririmidin-carboxamidas sustituidas con actividad anti-leucemia.

Country Status (21)

Country Link
US (1) US4636508A (es)
JP (1) JPS6259264A (es)
CN (2) CN1014990B (es)
AT (1) AT391864B (es)
AU (3) AU592559B2 (es)
BE (1) BE904641A (es)
CA (1) CA1274509A (es)
CH (1) CH668970A5 (es)
DE (1) DE3613447A1 (es)
DK (1) DK182986A (es)
ES (3) ES8800671A1 (es)
FR (1) FR2580642B1 (es)
GB (1) GB2174391B (es)
GR (1) GR861024B (es)
IL (2) IL78576A0 (es)
IT (1) IT1214499B (es)
LU (1) LU86403A1 (es)
NL (1) NL8601023A (es)
NZ (1) NZ215874A (es)
SE (1) SE8601826L (es)
ZA (1) ZA862630B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845217A (en) * 1985-05-17 1989-07-04 Uniroyal Chemical Ltd./Ltee Purification of 5-pyrimidinecarboxamides
US4920126A (en) * 1988-05-10 1990-04-24 Uniroyal Chemical Ltd/Uniroyal Chemical Ltee Barbituric acid derivative and treatment of leukemia and tumors therewith
FR2628869A1 (es) * 1988-07-14 1989-09-22 Uniroyal Chemical Ltd
FR2628741A1 (fr) * 1988-07-14 1989-09-22 Uniroyal Chemical Ltd Nouveaux composes n-phenyl-5-pyrimidinecarboxamides et composition pharmaceutique les contenant utilisable pour induire la regression de la leucemie ou des tumeurs
EP0430885A3 (en) * 1989-12-01 1991-11-06 Ciba-Geigy Ag Anthelmintical compounds
EP1441734B1 (en) * 2001-10-26 2007-02-28 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
US9428466B2 (en) 2013-11-13 2016-08-30 Raymond P. Warrell, Jr. Methods for reducing uric acid levels using barbiturate derivatives
US10093631B2 (en) * 2014-02-14 2018-10-09 Acquist Llc Bifunctional compounds and use for reducing uric acid levels
JP2018502896A (ja) 2015-01-22 2018-02-01 ピー．，ジュニア ワーレル，レイモンド 二機能性化合物および尿酸レベルを低下させるための使用
TWI772309B (zh) 2016-06-30 2022-08-01 美商艾克奎斯特有限責任公司 化合物及其於降低尿酸位準之用途(二)
ES2925186T3 (es) 2016-07-06 2022-10-14 Acquist Llc Compuestos y su uso para reducir los niveles de ácido úrico
US11130740B2 (en) 2017-04-25 2021-09-28 Arbutus Biopharma Corporation Substituted 2,3-dihydro-1H-indene analogs and methods using same
US12083118B2 (en) 2018-03-29 2024-09-10 Arbutus Biopharma Corporation Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670756A1 (de) * 1966-10-05 1970-12-23 Hoechst Ag Verfahren zur Herstellung von 6-Amino-uracil-5-carbonamid-N-sulfonamiden
DE2405733C2 (de) * 1974-02-07 1984-12-13 Bayer Ag, 5090 Leverkusen Amidocarbonylthiobarbitursäurederivate und deren Salze, Verfahren zu ihrer Herstellung sowie ihre Verwendung zur Bekämpfung von Insekten, Milben und Pilzen
CH614944A5 (en) * 1974-04-16 1979-12-28 Sandoz Ag Process for the preparation of novel pyrimidine derivatives
DE2719777A1 (de) * 1976-05-06 1977-11-24 Ciba Geigy Ag Neue 5-phenylcarbamoyl-barbitursaeuren
PL103086B1 (pl) * 1976-05-06 1979-05-31 Ciba Geigy Ag Srodek owadobojczy
US4283444A (en) * 1978-09-12 1981-08-11 Ciba-Geigy Corporation Method of protecting keratinous material from attack by insects that feed on keratin by treatment with 5-phenylcarbamoylbarbituric acid compounds
US4349552A (en) * 1978-10-30 1982-09-14 Fujisawa Pharmaceutical Company, Ltd. 5-Fluorouracil derivatives, and their pharmaceutical compositions
JPS5625166A (en) * 1979-08-09 1981-03-10 Banyu Pharmaceut Co Ltd 5-fluorouracil derivative
JPS5843960A (ja) * 1981-09-10 1983-03-14 Shoichiro Ozaki ５−フルオロウラシル誘導体，その製造法および制ガン剤
DE3347795A1 (de) * 1983-01-14 1985-08-01 Ozaki, Shoichiro, Ehime Neue 1-(n-substituierte carbamoyl)-5-fluorouracil-derivate und krebshemmende mittel, in denen sie als aktive bestandteile enthalten sind
JPS6012322A (ja) * 1983-07-01 1985-01-22 Toyota Motor Corp 四リンク型サスペンシヨン
IL73840A (en) * 1983-12-19 1988-11-15 Uniroyal Chem Co Inc 2-thio-5-(thio)carbamoyl barbituric acid derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU5641886A (en) 1986-10-30
IL78576A0 (en) 1986-08-31
IT8620153A0 (it) 1986-04-18
NZ215874A (en) 1988-09-29
SE8601826D0 (sv) 1986-04-21
CN1038450A (zh) 1990-01-03
ZA862630B (en) 1986-11-26
US4636508A (en) 1987-01-13
GB2174391A (en) 1986-11-05
IT1214499B (it) 1990-01-18
ES8800671A1 (es) 1987-11-16
CN86102767A (zh) 1987-01-07
AU2219688A (en) 1989-01-05
NL8601023A (nl) 1986-11-17
BE904641A (fr) 1986-10-21
ES8801219A1 (es) 1987-12-16
DE3613447C2 (es) 1991-04-11
CN1014990B (zh) 1991-12-04
FR2580642A1 (fr) 1986-10-24
DK182986A (da) 1986-10-23
AU592559B2 (en) 1990-01-18
SE8601826L (sv) 1986-10-23
ATA101986A (de) 1990-06-15
GB8609244D0 (en) 1986-05-21
LU86403A1 (fr) 1987-12-07
ES557684A0 (es) 1988-01-01
GB2174391B (en) 1988-12-29
DK182986D0 (da) 1986-04-21
DE3613447A1 (de) 1986-10-30
FR2580642B1 (fr) 1988-12-30
AT391864B (de) 1990-12-10
CA1274509A (en) 1990-09-25
ES554245A0 (es) 1987-11-16
CH668970A5 (de) 1989-02-15
JPS6259264A (ja) 1987-03-14
AU2219588A (en) 1989-01-05
GR861024B (en) 1986-08-14
ES557683A0 (es) 1987-12-16
IL86711A0 (en) 1988-11-30

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