ES8801226A1 - Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazacicloalcadieno. - Google Patents

Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazacicloalcadieno.

Info

Publication number
ES8801226A1
ES8801226A1 ES555536A ES555536A ES8801226A1 ES 8801226 A1 ES8801226 A1 ES 8801226A1 ES 555536 A ES555536 A ES 555536A ES 555536 A ES555536 A ES 555536A ES 8801226 A1 ES8801226 A1 ES 8801226A1
Authority
ES
Spain
Prior art keywords
denotes
mercapto
etherified
radicals
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555536A
Other languages
English (en)
Other versions
ES555536A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES555536A0 publication Critical patent/ES555536A0/es
Publication of ES8801226A1 publication Critical patent/ES8801226A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 3-MERCAPTO-1,2,4-TRIAZACICLOALCADIENO, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN DESCARBOXILAR UN COMPUESTO DE FORMULA GENERAL (II), EN EL QUE R''''3 SIGNIFICA UN RESTO SUSTITUIDO EN CASO DADO POR UN RESTO CARBOXI ADICIONAL, POR EJEMPLO UN RESTO 1,1-DICARBOXIALQUILO INFERIOR O UN RESTO 1-CARBOXI-2-OXO-ALQUILO INFERIOR. DICHO RESTO R''''3 SE DESCARBOXILA PARA DAR EL GRUPO R3 DESEADO, EFECTUANDOSE LA DISOCIACION DE DIOXIDO DE CARBONO MEDIANTE LA ACTUACION DE UN ACIDO MINERAL EN UN DISOLVENTE O DILUYENTE, EN CASO NECESARIO BAJO CALENTAMIENTO ENTRE 50 Y 250 GRADOS. DE APLICACION EN FARMACIA POR SU EFECTO ANTIINFLAMATORIO.
ES555536A 1984-03-16 1986-05-30 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazacicloalcadieno. Expired ES8801226A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH133084 1984-03-16

Publications (2)

Publication Number Publication Date
ES555536A0 ES555536A0 (es) 1988-01-01
ES8801226A1 true ES8801226A1 (es) 1988-01-01

Family

ID=4207944

Family Applications (7)

Application Number Title Priority Date Filing Date
ES541325A Expired ES8702377A1 (es) 1984-03-16 1985-03-15 Procedimiento para la obtencion de nuevos derivados de 3- mercapto-1,2,4-triazacicloalcadieno
ES555534A Expired ES8800913A1 (es) 1984-03-16 1986-05-30 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazacicloalcadieno
ES555536A Expired ES8801226A1 (es) 1984-03-16 1986-05-30 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazacicloalcadieno.
ES555533A Expired ES8801224A1 (es) 1984-03-16 1986-05-30 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazazacicloalcadieno
ES555537A Expired ES8800914A1 (es) 1984-03-16 1986-05-30 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazacicloalcadieno
ES555535A Expired ES8801225A1 (es) 1984-03-16 1986-05-30 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2-,4-triazacicloalcadieno.
ES557461A Expired ES8801804A1 (es) 1984-03-16 1987-03-18 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazacicloalcadieno

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES541325A Expired ES8702377A1 (es) 1984-03-16 1985-03-15 Procedimiento para la obtencion de nuevos derivados de 3- mercapto-1,2,4-triazacicloalcadieno
ES555534A Expired ES8800913A1 (es) 1984-03-16 1986-05-30 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazacicloalcadieno

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES555533A Expired ES8801224A1 (es) 1984-03-16 1986-05-30 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazazacicloalcadieno
ES555537A Expired ES8800914A1 (es) 1984-03-16 1986-05-30 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazacicloalcadieno
ES555535A Expired ES8801225A1 (es) 1984-03-16 1986-05-30 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2-,4-triazacicloalcadieno.
ES557461A Expired ES8801804A1 (es) 1984-03-16 1987-03-18 Procedimiento para la obtencion de nuevos derivados de 3-mercapto-1,2,4-triazacicloalcadieno

Country Status (15)

Country Link
EP (1) EP0157259A1 (es)
JP (1) JPS60209574A (es)
KR (1) KR850006387A (es)
AU (1) AU4004085A (es)
DD (1) DD234006A5 (es)
DK (1) DK119685A (es)
ES (7) ES8702377A1 (es)
FI (1) FI850995L (es)
GR (1) GR850652B (es)
HU (1) HUT37408A (es)
IL (1) IL74596A0 (es)
NO (1) NO851036L (es)
PH (1) PH21777A (es)
PT (1) PT80105B (es)
ZA (1) ZA851952B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931083A (en) * 1985-11-12 1990-06-05 Eli Lilly And Company Plant growth regulating triazoles
PT83711B (en) * 1985-11-12 1988-12-06 Lilly Co Eli Process for preparing plant growth regulating triazoles
AUPR878201A0 (en) * 2001-11-09 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. New compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2558951A1 (de) * 1974-12-28 1976-07-08 Canon Kk Durch erwaermung entwickelbares, lichtempfindliches material
DK16778A (da) * 1977-02-09 1978-08-10 Du Pont Imidazolderivater deres anvendelser og fremstilling
DE2856909A1 (de) * 1978-12-28 1980-07-17 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Also Published As

Publication number Publication date
GR850652B (es) 1985-07-16
ES8801804A1 (es) 1988-02-16
FI850995A7 (fi) 1985-09-17
NO851036L (no) 1985-09-17
KR850006387A (ko) 1985-10-05
ES555534A0 (es) 1987-12-01
HUT37408A (en) 1985-12-28
FI850995L (fi) 1985-09-17
AU4004085A (en) 1985-09-19
JPS60209574A (ja) 1985-10-22
ES8800914A1 (es) 1987-12-01
ES541325A0 (es) 1987-01-01
FI850995A0 (fi) 1985-03-13
DD234006A5 (de) 1986-03-19
ES555537A0 (es) 1987-12-01
ES8801224A1 (es) 1987-12-16
PT80105A (en) 1985-04-01
PT80105B (en) 1987-03-24
ES555535A0 (es) 1988-01-01
ES8702377A1 (es) 1987-01-01
ES555536A0 (es) 1988-01-01
IL74596A0 (en) 1985-06-30
ZA851952B (en) 1985-11-27
EP0157259A1 (de) 1985-10-09
DK119685D0 (da) 1985-03-15
DK119685A (da) 1985-09-17
ES8801225A1 (es) 1988-01-01
ES555533A0 (es) 1987-12-16
ES557461A0 (es) 1988-02-16
ES8800913A1 (es) 1987-12-01
PH21777A (en) 1988-02-24

Similar Documents

Publication Publication Date Title
DK245888A (da) 4-aminoquinolinderivater
ES414279A1 (es) Procedimiento para la preparacion de 1,4-benzodiazepinas.
KR960014121A (ko) 아로일-피페리딘 유도체
KR960004344A (ko) 6원 질소 함유 헤테로아릴-옥사졸리디논
DE69104723D1 (de) Hustenstillendes und schleimregulierendes mittel, verfahren zu seiner herstellung und dieses enthaltende pharmazeutische zusammensetzungen.
HUP9802323A2 (hu) Pirimidinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyászati készítmények
ES8700660A1 (es) Un procedimiento para la preparacion de derivados de bencimidasol.
KR900001677A (ko) 비아릴 화합물
KR900018065A (ko) 벤조시클로알칸 유도체 및 그의 제조방법
ATE59632T1 (de) Dihydrodibenzocycloheptylidenethylamin-derivate
ATE28641T1 (de) Pharmazeutische praeparate, (+)-cyanidan-3-olderivate enthaltend, deren verwendung, substituierte (+)-cyanidan-3-ol derivate und verfahren zu deren herstellung.
GEP19981357B (en) New Adenozine Derivatives, Prepatation Methods and Pharmaceutical Composit¬i¬ons Containing Them
DE3869075D1 (de) 2-piperazinyl-2-oxo-aethylensubstituierte flavonoid-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammenstellungen.
ATE45878T1 (de) Pharmazeutische praeparate enthaltend flavenoder thioflaven-derivate, deren verwendung, flavene und thioflavene und verfahren zu deren herstellung.
ES539160A0 (es) Un procedimiento para preparar derivados de penem
EP0315434A3 (en) Pyridoxal hydrazone derivatives their production and use and pharmaceutical compositions containing the same
DK415984A (da) Flavanon- og thioflavanonderivater og salte deraf samt deres fremstilling og anvendelse
ATE79752T1 (de) Verwendung von chromanderivaten zur herstellung eines medikamentes zur behandlung von depressiven zustaenden.
KR910011258A (ko) 녹내장의 치료방법
ES472208A1 (es) Procedimiento para la obtencion de nuevos derivados de 2- bencimidazol.
HUP0000414A2 (hu) Új pentaeritritszármazékok, előállításuk, alkalmazásuk és intermedierjeik
KR890003713A (ko) 피페라진 유도체