ES8801267A1 - Procedimiento para preparar derivados de isoquinolinona - Google Patents
Procedimiento para preparar derivados de isoquinolinonaInfo
- Publication number
- ES8801267A1 ES8801267A1 ES557171A ES557171A ES8801267A1 ES 8801267 A1 ES8801267 A1 ES 8801267A1 ES 557171 A ES557171 A ES 557171A ES 557171 A ES557171 A ES 557171A ES 8801267 A1 ES8801267 A1 ES 8801267A1
- Authority
- ES
- Spain
- Prior art keywords
- pyrimido
- derivatives
- isoquinolin
- isoquinoline
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YTWIBNSJMKAVML-UHFFFAOYSA-N pyrimido[2,1-a]isoquinolin-4-one Chemical class C1=CC=C2C=CN3C(=O)C=CN=C3C2=C1 YTWIBNSJMKAVML-UHFFFAOYSA-N 0.000 title abstract 3
- 229940125709 anorectic agent Drugs 0.000 abstract 2
- 239000002830 appetite depressant Substances 0.000 abstract 2
- HDZKTMAAJYURAD-UHFFFAOYSA-N 4h-pyrimido[2,1-a]isoquinoline Chemical class C1=CC=C2C3=NC=CCN3C=CC2=C1 HDZKTMAAJYURAD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ISOQUINOLINONA, DE FORMULA GENERAL (I), Y DE SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN DERIVADO DE PIRIMIDO 2,1-AISOQUINOLIN-4-ONA, DE FORMULA GENERAL (II), EN LA QUE Z ES UN GRUPO ESTER DISOCIABLE, CON UNA N1,N-DIALQUILALQUENDIAMINA, DE FORMULA GENERAL (III), EN LA QUE N ES UN ENTERO DE 1 A 4; Y R1 Y R2 SON INDEPENDIENTEMENTE, HIDROGENO O ALQUILO INFERIOR, EN PRESENCIA DE UN DISOLVENTE ORGANICO Y A LA TEMPERATURA DE REFLUJO DE LA MEZCLA DE REACCION. DE APLICACION COMO AGENTES ANORECTICOS UTILIZADOS PARA FINES TERAPEUTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/625,061 US4661592A (en) | 1984-06-27 | 1984-06-27 | 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES557171A0 ES557171A0 (es) | 1988-01-01 |
| ES8801267A1 true ES8801267A1 (es) | 1988-01-01 |
Family
ID=24504413
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544581A Expired ES8703872A1 (es) | 1984-06-27 | 1985-06-26 | Procedimiento para preparar derivados de isoquinolina. |
| ES557171A Expired ES8801267A1 (es) | 1984-06-27 | 1986-10-31 | Procedimiento para preparar derivados de isoquinolinona |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544581A Expired ES8703872A1 (es) | 1984-06-27 | 1985-06-26 | Procedimiento para preparar derivados de isoquinolina. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4661592A (es) |
| EP (1) | EP0166439B1 (es) |
| JP (1) | JPS6124593A (es) |
| AU (1) | AU4417985A (es) |
| DE (1) | DE3577559D1 (es) |
| ES (2) | ES8703872A1 (es) |
| ZA (1) | ZA854877B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO162019C (no) * | 1983-11-23 | 1989-10-25 | Fujisawa Pharmaceutical Co | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater. |
| JPH0619904Y2 (ja) * | 1988-09-16 | 1994-05-25 | 株式会社クボタ | 管継手 |
| JPH0726632Y2 (ja) * | 1990-09-28 | 1995-06-14 | 徳厚 小島 | 管継手 |
| WO2008148074A2 (en) * | 2007-05-24 | 2008-12-04 | Research Foundation Of State University Of New York | Inhibitors of mtor and methods of treatment using same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU168014B (es) * | 1973-03-30 | 1976-02-28 | ||
| US4127720A (en) * | 1977-09-21 | 1978-11-28 | Bristol-Myers Company | Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity |
| US4348396A (en) * | 1978-01-23 | 1982-09-07 | Hoffmann-La Roche Inc. | Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them |
| NO162019C (no) * | 1983-11-23 | 1989-10-25 | Fujisawa Pharmaceutical Co | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater. |
-
1984
- 1984-06-27 US US06/625,061 patent/US4661592A/en not_active Expired - Fee Related
-
1985
- 1985-06-26 ES ES544581A patent/ES8703872A1/es not_active Expired
- 1985-06-26 AU AU44179/85A patent/AU4417985A/en not_active Abandoned
- 1985-06-26 JP JP13809485A patent/JPS6124593A/ja active Pending
- 1985-06-27 EP EP85107949A patent/EP0166439B1/en not_active Expired - Lifetime
- 1985-06-27 DE DE8585107949T patent/DE3577559D1/de not_active Expired - Fee Related
- 1985-06-27 ZA ZA854877A patent/ZA854877B/xx unknown
-
1986
- 1986-10-31 ES ES557171A patent/ES8801267A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0166439A3 (en) | 1987-05-20 |
| ES8703872A1 (es) | 1987-03-01 |
| JPS6124593A (ja) | 1986-02-03 |
| EP0166439A2 (en) | 1986-01-02 |
| ZA854877B (en) | 1986-08-27 |
| DE3577559D1 (de) | 1990-06-13 |
| AU4417985A (en) | 1986-01-02 |
| US4661592A (en) | 1987-04-28 |
| ES557171A0 (es) | 1988-01-01 |
| ES544581A0 (es) | 1987-03-01 |
| EP0166439B1 (en) | 1990-05-09 |
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