ES8801578A1 - Un procedimiento para preparar una formulacion en emulsion de anfotericina b adecuada para administracion parenteral. - Google Patents

Un procedimiento para preparar una formulacion en emulsion de anfotericina b adecuada para administracion parenteral.

Info

Publication number
ES8801578A1
ES8801578A1 ES555005A ES555005A ES8801578A1 ES 8801578 A1 ES8801578 A1 ES 8801578A1 ES 555005 A ES555005 A ES 555005A ES 555005 A ES555005 A ES 555005A ES 8801578 A1 ES8801578 A1 ES 8801578A1
Authority
ES
Spain
Prior art keywords
emulsion formulation
polyene antibiotic
antibiotic emulsion
animal
polyene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555005A
Other languages
English (en)
Other versions
ES555005A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24956040&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8801578(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of ES555005A0 publication Critical patent/ES555005A0/es
Publication of ES8801578A1 publication Critical patent/ES8801578A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA FORMULACION EN EMULSION DE ANFOTERICINA B, ADECUADA PARA LA ADMINISTRACION PARENTERAL. COMPRENDE LAS OPERACIONES DE AÑADIR ANFOTERICINA B A UN DISOLVENTE SELECCIONADO DE DIMETILACETAMIDA, PIRIDINA, DIMETILFORMAMIDA, DIMETILSULFOXIDO, POLIETILENGLICOL O CARBONATO DE DIETILO, PARA LA FORMACION DE UNA MEZCLA; DE SEPARAR LA ANFOTERICINA B NO DISUELTA MEDIANTE FILTRACION DE LA MEZCLA; Y DE INCORPORAR LA ANFOTERICINA B DISUELTA EN UNA EMULSION DEL TIPO DE ACEITE EN AGUA, CON UNA CONCENTRACION DE ACEITE COMPRENDIDA ENTRE ACEITE DE SEMILLA DE SESAMO, ACEITE DE SOJA, ACEITE DE MAIZ, ACEITE DE CACAHUETE Y MIRISTATO DE ISOPROPILO.
ES555005A 1985-05-17 1986-05-16 Un procedimiento para preparar una formulacion en emulsion de anfotericina b adecuada para administracion parenteral. Expired ES8801578A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/735,492 US4707470A (en) 1985-05-17 1985-05-17 Polyene antibiotic emulsion formulation

Publications (2)

Publication Number Publication Date
ES555005A0 ES555005A0 (es) 1988-02-16
ES8801578A1 true ES8801578A1 (es) 1988-02-16

Family

ID=24956040

Family Applications (1)

Application Number Title Priority Date Filing Date
ES555005A Expired ES8801578A1 (es) 1985-05-17 1986-05-16 Un procedimiento para preparar una formulacion en emulsion de anfotericina b adecuada para administracion parenteral.

Country Status (11)

Country Link
US (1) US4707470A (es)
EP (1) EP0202837B1 (es)
JP (1) JPS61268625A (es)
AT (1) ATE47312T1 (es)
AU (1) AU589961B2 (es)
DE (1) DE3666347D1 (es)
DK (1) DK223686A (es)
ES (1) ES8801578A1 (es)
GR (1) GR861225B (es)
PT (1) PT82564B (es)
ZA (1) ZA863639B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4831018A (en) * 1985-05-17 1989-05-16 Smithkline Beckman Corporation Polyene antibiotic emulsion formulation
US4784845A (en) * 1985-09-16 1988-11-15 American Cyanamid Company Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs
US4826822A (en) * 1986-04-22 1989-05-02 Ecolab Inc. Liquid suspensions of polyene antibiotics and use thereof for slime control in industrial waters
US4822777A (en) * 1987-02-27 1989-04-18 Liposome Technology, Inc. Amphotericin B/cholesterol sulfate composition
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
GB8714652D0 (en) * 1987-06-23 1987-07-29 Davis S S Drug emulsion
US4981690A (en) * 1987-10-27 1991-01-01 Board Of Regents, The University Of Texas System Liposome-incorporated mepartricin
EP0393890B1 (en) * 1989-04-11 1992-08-12 Pfizer Limited Injectable compositions containing 25-cyclohexyl-avermectin b1
GB8919172D0 (en) * 1989-08-23 1989-10-04 Univ Nottingham Useful composition
AU6461090A (en) * 1989-10-30 1991-05-02 Abbott Laboratories Injectable formulation for lipophilic drugs
US5054995A (en) * 1989-11-06 1991-10-08 Ingersoll-Rand Company Apparatus for controlling a fluid compression system
ATE140622T1 (de) * 1989-11-27 1996-08-15 Nippon Shinyaku Co Ltd Fettemulsion
US5210226A (en) * 1990-02-02 1993-05-11 Xechem Inc. Method for separating and purifying polyene macrolide antibiotics
US5258519A (en) * 1990-11-13 1993-11-02 Glaxo Inc. Dihydropyridine vasodilators agents
US5622649A (en) * 1991-06-27 1997-04-22 Emory University Multiple emulsions and methods of preparation
SG49652A1 (en) * 1992-03-30 1998-06-15 American Home Prod Rapamycin formulation for iv injection
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
US5980945A (en) * 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
GB9601120D0 (en) 1996-01-19 1996-03-20 Sandoz Ltd Organic compounds
IN188843B (es) * 2000-06-22 2002-11-09 Vinod Daftary Gautam Dr
DE10036871A1 (de) * 2000-07-28 2002-02-14 Pharmasol Gmbh Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe
WO2009102814A2 (en) * 2008-02-11 2009-08-20 Accentia Biopharmaceuticals, Inc. Mucosally non-irritative liquid amphotericin b formulations and methods for treating non-invasive fungus-induced mucositis
US8993625B2 (en) 2009-03-11 2015-03-31 Stable Solutions Llc Method of mitigating adverse drug events using omega-3 fatty acids as a parenteral therapeutic drug vehicle
US9034389B2 (en) * 2009-03-11 2015-05-19 Stable Solutions Llc Omega-3 enriched fish oil-in-water parenteral nutrition emulsions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3096249A (en) * 1960-05-10 1963-07-02 Samuel J Prigal Emulsion composition
GB1148801A (en) * 1965-06-09 1969-04-16 Miles Lab Stabilised antibiotic compositions
GB1171125A (en) * 1966-06-08 1969-11-19 Glaxo Lab Ltd Improvements in or relating to Injectable Preparations
US3651218A (en) * 1970-06-03 1972-03-21 Miles Lab Antifungal compositions
US4148891A (en) * 1974-07-03 1979-04-10 Gist-Brocades N.V. Antifungal preparations
US4073943A (en) * 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US4025620A (en) * 1975-10-22 1977-05-24 Leo Pharmaceutical Products Ltd., A/S Treatment of canine otitis and composition therefor
US4100271A (en) * 1976-02-26 1978-07-11 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4168308A (en) * 1976-03-12 1979-09-18 Apoteksvarucentralen Vitrum Ab Composition for enhancing the administration of pharmacologically active agents
WO1982001821A1 (en) * 1980-11-27 1982-06-10 Kovacs Andras Antimycotic synergistic pharmaceutical compositions and process for the preparation thereof
DE3210138A1 (de) * 1982-03-19 1983-09-22 Röhm Pharma GmbH, 6100 Darmstadt Antimykotische, therapeutische zubereitungen auf creme- und salbenbasis
FR2553661B1 (fr) * 1983-10-19 1985-12-20 Rhone Poulenc Sante Nouvelles microemulsions pharmaceutiquement acceptables
US4542020A (en) * 1984-08-17 1985-09-17 E. R. Squibb & Sons, Inc. Long-lasting adhesive antifungal suppositories

Also Published As

Publication number Publication date
PT82564A (en) 1986-06-01
ZA863639B (en) 1987-06-24
DK223686A (da) 1986-11-18
ES555005A0 (es) 1988-02-16
DK223686D0 (da) 1986-05-14
DE3666347D1 (en) 1989-11-23
EP0202837B1 (en) 1989-10-18
PT82564B (en) 1987-12-14
GR861225B (en) 1986-09-10
ATE47312T1 (de) 1989-11-15
JPS61268625A (ja) 1986-11-28
EP0202837A1 (en) 1986-11-26
AU589961B2 (en) 1989-10-26
AU5733386A (en) 1986-11-20
US4707470A (en) 1987-11-17

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