ES8802185A1 - A METHOD FOR PREPARING A USEFUL ANTIBODY FOR THE DETECTION OF AN EPIDERMIC GROWTH FACTOR - Google Patents

A METHOD FOR PREPARING A USEFUL ANTIBODY FOR THE DETECTION OF AN EPIDERMIC GROWTH FACTOR

Info

Publication number
ES8802185A1
ES8802185A1 ES554629A ES554629A ES8802185A1 ES 8802185 A1 ES8802185 A1 ES 8802185A1 ES 554629 A ES554629 A ES 554629A ES 554629 A ES554629 A ES 554629A ES 8802185 A1 ES8802185 A1 ES 8802185A1
Authority
ES
Spain
Prior art keywords
growth factor
preparing
detection
useful antibody
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554629A
Other languages
Spanish (es)
Other versions
ES554629A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of ES554629A0 publication Critical patent/ES554629A0/en
Publication of ES8802185A1 publication Critical patent/ES8802185A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Polypeptides having growth factor activity and precursors thereof are synthesized using conventional or recombinant techniques. The framework structure of these peptides are shown in figures 1 and 2. The structure, particularly those involving six cysteines, provide loops analogous to mammalian growth factors. The peptides are disclosed as being useful as mitogens, additives in nutrient media, in assays for Epidermal Growth Factors (EGF) receptors, and in wound healing.
ES554629A 1984-10-30 1986-04-30 A METHOD FOR PREPARING A USEFUL ANTIBODY FOR THE DETECTION OF AN EPIDERMIC GROWTH FACTOR Expired ES8802185A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66652084A 1984-10-30 1984-10-30

Publications (2)

Publication Number Publication Date
ES554629A0 ES554629A0 (en) 1988-04-01
ES8802185A1 true ES8802185A1 (en) 1988-04-01

Family

ID=24674411

Family Applications (7)

Application Number Title Priority Date Filing Date
ES548316A Expired ES8702925A1 (en) 1984-10-30 1985-10-29 A PROCEDURE FOR PREPARING A POLYPEPTIDE THAT HAS A GROWTH FACTOR ACTIVITY
ES554629A Expired ES8802185A1 (en) 1984-10-30 1986-04-30 A METHOD FOR PREPARING A USEFUL ANTIBODY FOR THE DETECTION OF AN EPIDERMIC GROWTH FACTOR
ES554628A Expired ES8802061A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554630A Expired ES8802074A1 (en) 1984-10-30 1986-04-30 A METHOD FOR PREPARING AN EXPRESSION VECTOR THAT HAS A FUNCTIONAL REPLICATION SYSTEM IN A HOSTING MICROORGANISM
ES557145A Expired ES8707741A1 (en) 1984-10-30 1986-10-24 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557708A Expired ES8801378A1 (en) 1984-10-30 1987-09-01 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557710A Expired ES8801379A1 (en) 1984-10-30 1987-09-01 A METHOD FOR PREPARING A DNA SEQUENCE THAT CODES A POLYPEPTIDE THAT HAS GROWTH FACTOR ACTIVITY

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES548316A Expired ES8702925A1 (en) 1984-10-30 1985-10-29 A PROCEDURE FOR PREPARING A POLYPEPTIDE THAT HAS A GROWTH FACTOR ACTIVITY

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES554628A Expired ES8802061A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554630A Expired ES8802074A1 (en) 1984-10-30 1986-04-30 A METHOD FOR PREPARING AN EXPRESSION VECTOR THAT HAS A FUNCTIONAL REPLICATION SYSTEM IN A HOSTING MICROORGANISM
ES557145A Expired ES8707741A1 (en) 1984-10-30 1986-10-24 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557708A Expired ES8801378A1 (en) 1984-10-30 1987-09-01 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557710A Expired ES8801379A1 (en) 1984-10-30 1987-09-01 A METHOD FOR PREPARING A DNA SEQUENCE THAT CODES A POLYPEPTIDE THAT HAS GROWTH FACTOR ACTIVITY

Country Status (12)

Country Link
EP (1) EP0199769A4 (en)
JP (1) JPS62501071A (en)
AU (2) AU600433B2 (en)
ES (7) ES8702925A1 (en)
FI (1) FI862734L (en)
GR (1) GR852610B (en)
IL (1) IL76866A0 (en)
NO (1) NO862613L (en)
NZ (1) NZ213984A (en)
PH (2) PH24603A (en)
PT (1) PT81408B (en)
WO (1) WO1986002650A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240912A (en) * 1983-05-09 1993-08-31 Todaro George J Transforming growth factor (TGF) peptides
US4863899A (en) * 1983-05-09 1989-09-05 Todaro George J Biologically active polypeptides
EP0228036A3 (en) * 1985-12-18 1988-09-07 Microgenesys, Inc. Method for producing selected polypeptides in virally infected insect cells and polypeptides isolated therefrom
IL89673A0 (en) * 1988-03-24 1989-09-28 Oncogen Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE38892B1 (en) * 1973-03-28 1978-06-21 Ici Ltd Pharmaceutical compositions
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US4230691A (en) * 1978-05-23 1980-10-28 The Massachusetts General Hospital Nerve growth factor antibody and process
DK339781A (en) * 1980-08-05 1982-02-06 Searle & Co SYNTHETIC GEN
JPH064673B2 (en) * 1980-11-10 1994-01-19 ゲネンテツク・インコ−ポレ−テツド Hybrid type human leukocyte interferon
WO1985002198A1 (en) * 1983-11-01 1985-05-23 Amgen Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
GB8507666D0 (en) * 1985-03-25 1985-05-01 Wellcome Found Epidermal growth factor production

Also Published As

Publication number Publication date
FI862734A7 (en) 1986-06-26
FI862734A0 (en) 1986-06-26
NO862613D0 (en) 1986-06-27
IL76866A0 (en) 1986-02-28
PH25794A (en) 1991-11-05
ES8702925A1 (en) 1987-01-16
ES8802061A1 (en) 1988-03-16
PT81408A (en) 1985-11-01
ES557145A0 (en) 1987-08-16
ES557710A0 (en) 1988-01-01
NO862613L (en) 1986-06-27
AU6655190A (en) 1991-01-24
ES8707741A1 (en) 1987-08-16
GR852610B (en) 1986-03-04
WO1986002650A1 (en) 1986-05-09
ES554629A0 (en) 1988-04-01
JPS62501071A (en) 1987-04-30
AU600433B2 (en) 1990-08-16
ES554628A0 (en) 1988-03-16
PT81408B (en) 1987-11-11
ES8801379A1 (en) 1988-01-01
AU633377B2 (en) 1993-01-28
EP0199769A4 (en) 1989-11-29
ES8802074A1 (en) 1988-03-16
PH24603A (en) 1990-08-17
ES8801378A1 (en) 1988-01-01
ES554630A0 (en) 1988-03-16
EP0199769A1 (en) 1986-11-05
NZ213984A (en) 1991-05-28
ES557708A0 (en) 1988-01-01
FI862734L (en) 1986-06-26
AU4868785A (en) 1986-05-15
ES548316A0 (en) 1987-01-16

Similar Documents

Publication Publication Date Title
PT85349A (en) Method for the preparation of proteins with factor viii activity by microbial host cells expression vectors host cells antibodies
DE69112207D1 (en) "walk-through"-mutagenese.
ES8305701A1 (en) PROCEDURE FOR THE PRODUCTION OF A POLYPEPTIDE.
DE69132530D1 (en) HEPARIN BINDING MITOGEN WITH HOMOLOGY OF THE EPIDERMIS GROWTH FACTOR (EGF)
ATE56728T1 (en) NEW POLYPEPTIDES WITH ALPHA-AMYLASE INHIBITOR ACTIVITY, PROCESS FOR THEIR PRODUCTION, THEIR USE AND PHARMACEUTICAL PREPARATIONS.
ATE272109T1 (en) RECOMBINANT COLLAGENASE TYPE I FROM CLOSTRIDIUM HISTOLYTICUM AND THE USE THEREOF FOR ISOLATING CELLS AND CELL COMPOUNDS
DE3851289D1 (en) Method of growing recombinant cells.
ATE153858T1 (en) LIGAND FOR THE NEW GENE PRODUCT
EP0434713A4 (en) Hiv-1 envelope muteins lacking hypervariable domains
DE3484391D1 (en) PRODUCTION OF PEPTIDES AND THEIR USE.
BG101408A (en) ANALYSIS OF KERATINOTINE GROWTH FACTOR
ATE177472T1 (en) EXPRESSION OF MACROPHAGE-INDUCABLE PROTEINS (MIPS) IN YEAST CELLS
ES520358A0 (en) PROCEDURE FOR PRODUCING POLYPEPTIDE
PT81941B (en) METHOD FOR PREPARING NEW PEPTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE3582895D1 (en) PEPTID, THEIR PRODUCTION AND USE.
PT1200561E (en) CLONE CELLULAR RECOMBINANT STABLE, ITS PRODUCTION AND UTILIZATION
ES2055611T3 (en) PROTEASE RESISTANT PDGF AND METHODS OF USE.
ES2109225T3 (en) ANTIBODIES, THEIR PRODUCTION AND USE.
ES2176260T3 (en) PROTEIN MEMBRANE POLYPEPTIDE THAT HAS THE FUNCTION OF MAINTAINING THE GROWTH OF PRE-B AND GEN CELLS FOR THE SAME.
KR900012626A (en) Hybrid protein, method for producing same, and pharmaceutical composition containing same
Rasmussen et al. Human thyroid epithelial cells cultured in monolayers. I. Decreased thyroglobulin and cAMP response to TSH in 12-week-old secondary and tertiary cultures
JPS6420086A (en) Polypeptide and production thereof
SE8901031L (en) NEW POLYPEPTIDES WITH ADDITION FACTOR ACTIVITY AND NUCLEIC ACID SEQUENCES CODING POLYPEPTIDES
ES554629A0 (en) A METHOD FOR PREPARING A USEFUL ANTIBODY FOR THE DETECTION OF AN EPIDERMIC GROWTH FACTOR
Ferguson II et al. Interleukin-1β and interleukin-4 increase parathyroid hormone—related protein secretion by human umbilical vein endothelial cells in culture

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401