ES8802185A1 - Un metodo para preparar un anticuerpo util para la deteccion de un factor de crecimiento epidermico - Google Patents

Un metodo para preparar un anticuerpo util para la deteccion de un factor de crecimiento epidermico

Info

Publication number
ES8802185A1
ES8802185A1 ES554629A ES554629A ES8802185A1 ES 8802185 A1 ES8802185 A1 ES 8802185A1 ES 554629 A ES554629 A ES 554629A ES 554629 A ES554629 A ES 554629A ES 8802185 A1 ES8802185 A1 ES 8802185A1
Authority
ES
Spain
Prior art keywords
growth factor
preparing
detection
useful antibody
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554629A
Other languages
English (en)
Other versions
ES554629A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of ES8802185A1 publication Critical patent/ES8802185A1/es
Publication of ES554629A0 publication Critical patent/ES554629A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

CONSISTE EN A) INYECTAR EN UN ANIMAL UNA CANTIDAD INMUNOGENETICAMENTE EFICAZ DE UN POLIPEPTIDO (I), CON GRUPOS Y RADICALES DEFINIDOS, Y B) OBTENER ESPLENOCITOS DEL ANIMAL, FUSIONARLOS CON UN COMPAÑERO PARA PRODUCIR LINEAS DE CELULAS HIBRIDOMAS C) CLONAR ESTOS HIBRIDOMAS QUE PRODUCEN UN ANTICUERPO DE FIJACION AL SITIO EPITOPICO DEL POLIPEPTIDO Y D) AISLAR DICHO ANTICUERPO. DICHAS SUSTANCIAS SON APLICABLES PARA EL DIAGNOSTICO SOBRE CELULAS, PARTICULARMENTE RELACIONADAS CON LA ACTIVIDAD DE FACTOR DE CRECIMIENTO, ASOCIADO CON LA ONCOGENICIDAD, SON MITOGENOS, AGONISTAS Y ANTAGONISTAS PARA EGF Y TGF, INMUNOGENOS Y MEJORAN LA CURACION DE HERIDAS.
ES554629A 1984-10-30 1986-04-30 Un metodo para preparar un anticuerpo util para la deteccion de un factor de crecimiento epidermico Expired ES8802185A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66652084A 1984-10-30 1984-10-30

Publications (2)

Publication Number Publication Date
ES8802185A1 true ES8802185A1 (es) 1988-04-01
ES554629A0 ES554629A0 (es) 1988-04-01

Family

ID=24674411

Family Applications (7)

Application Number Title Priority Date Filing Date
ES548316A Expired ES8702925A1 (es) 1984-10-30 1985-10-29 Un procedimiento para preparar un polipeptido que tiene ac- tividad de factor de crecimiento
ES554630A Expired ES8802074A1 (es) 1984-10-30 1986-04-30 Un metodo para preparar un vector de expresion que tiene un sistema de replicacion funcional en un microorganismo hospedante
ES554629A Expired ES8802185A1 (es) 1984-10-30 1986-04-30 Un metodo para preparar un anticuerpo util para la deteccion de un factor de crecimiento epidermico
ES554628A Expired ES8802061A1 (es) 1984-10-30 1986-04-30 Un metodo para preparar una secuencia de adn que codifica un polipeptido que tiene actividad de factor de crecimiento
ES557145A Expired ES8707741A1 (es) 1984-10-30 1986-10-24 Un procedimiento para prepara un polipeptido que tiene actividad de factor de crecimiento
ES557710A Expired ES8801379A1 (es) 1984-10-30 1987-09-01 Un metodo para preparar una secuencia de adn que codifica un polipeptido que tiene actividad de factor de crecimiento
ES557708A Expired ES8801378A1 (es) 1984-10-30 1987-09-01 Un metodo para preparar un vector de expresion que tiene un sistema de replicacion funcional en un microorganismo hospedante

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES548316A Expired ES8702925A1 (es) 1984-10-30 1985-10-29 Un procedimiento para preparar un polipeptido que tiene ac- tividad de factor de crecimiento
ES554630A Expired ES8802074A1 (es) 1984-10-30 1986-04-30 Un metodo para preparar un vector de expresion que tiene un sistema de replicacion funcional en un microorganismo hospedante

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES554628A Expired ES8802061A1 (es) 1984-10-30 1986-04-30 Un metodo para preparar una secuencia de adn que codifica un polipeptido que tiene actividad de factor de crecimiento
ES557145A Expired ES8707741A1 (es) 1984-10-30 1986-10-24 Un procedimiento para prepara un polipeptido que tiene actividad de factor de crecimiento
ES557710A Expired ES8801379A1 (es) 1984-10-30 1987-09-01 Un metodo para preparar una secuencia de adn que codifica un polipeptido que tiene actividad de factor de crecimiento
ES557708A Expired ES8801378A1 (es) 1984-10-30 1987-09-01 Un metodo para preparar un vector de expresion que tiene un sistema de replicacion funcional en un microorganismo hospedante

Country Status (12)

Country Link
EP (1) EP0199769A4 (es)
JP (1) JPS62501071A (es)
AU (2) AU600433B2 (es)
ES (7) ES8702925A1 (es)
FI (1) FI862734A7 (es)
GR (1) GR852610B (es)
IL (1) IL76866A0 (es)
NO (1) NO862613D0 (es)
NZ (1) NZ213984A (es)
PH (2) PH24603A (es)
PT (1) PT81408B (es)
WO (1) WO1986002650A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240912A (en) * 1983-05-09 1993-08-31 Todaro George J Transforming growth factor (TGF) peptides
US4863899A (en) * 1983-05-09 1989-09-05 Todaro George J Biologically active polypeptides
JPS63167797A (ja) * 1985-12-18 1988-07-11 マイクロジエネシス，インコ−ポレイテイド 選択された昆虫宿主細胞中で選択されたポリペプチドを製造する方法
IL89673A0 (en) * 1988-03-24 1989-09-28 Oncogen Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE38892B1 (en) * 1973-03-28 1978-06-21 Ici Ltd Pharmaceutical compositions
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US4230691A (en) * 1978-05-23 1980-10-28 The Massachusetts General Hospital Nerve growth factor antibody and process
IE53166B1 (en) * 1980-08-05 1988-08-03 Searle & Co Synthetic urogastrone gene,corresponding plasmid recombinants,transformed cells,production thereof and urogastrone expression
JPH064673B2 (ja) * 1980-11-10 1994-01-19 ゲネンテツク・インコ−ポレ−テツド ハイブリド型ヒト白血球インタフエロン
WO1985002198A1 (en) * 1983-11-01 1985-05-23 Amgen Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
GB8507666D0 (en) * 1985-03-25 1985-05-01 Wellcome Found Epidermal growth factor production

Also Published As

Publication number Publication date
EP0199769A4 (en) 1989-11-29
AU4868785A (en) 1986-05-15
PT81408A (en) 1985-11-01
EP0199769A1 (en) 1986-11-05
AU600433B2 (en) 1990-08-16
ES554630A0 (es) 1988-03-16
NO862613L (no) 1986-06-27
ES8802061A1 (es) 1988-03-16
AU633377B2 (en) 1993-01-28
ES554629A0 (es) 1988-04-01
NZ213984A (en) 1991-05-28
ES8801379A1 (es) 1988-01-01
FI862734L (fi) 1986-06-26
ES548316A0 (es) 1987-01-16
ES557710A0 (es) 1988-01-01
ES8801378A1 (es) 1988-01-01
ES8702925A1 (es) 1987-01-16
NO862613D0 (no) 1986-06-27
JPS62501071A (ja) 1987-04-30
FI862734A0 (fi) 1986-06-26
ES554628A0 (es) 1988-03-16
WO1986002650A1 (en) 1986-05-09
AU6655190A (en) 1991-01-24
FI862734A7 (fi) 1986-06-26
ES8707741A1 (es) 1987-08-16
PH25794A (es) 1991-11-05
IL76866A0 (en) 1986-02-28
ES557708A0 (es) 1988-01-01
GR852610B (es) 1986-03-04
PH24603A (en) 1990-08-17
ES557145A0 (es) 1987-08-16
ES8802074A1 (es) 1988-03-16
PT81408B (pt) 1987-11-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401