FI104251B1 - Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi - Google Patents

Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi

Info

Publication number
FI104251B1
FI104251B1 FI906273A FI906273A FI104251B1 FI 104251 B1 FI104251 B1 FI 104251B1 FI 906273 A FI906273 A FI 906273A FI 906273 A FI906273 A FI 906273A FI 104251 B1 FI104251 B1 FI 104251B1
Authority
FI
Finland
Prior art keywords
inflammatory bowel
compounds
preparation
treatment
benzyl
Prior art date
Application number
FI906273A
Other languages
English (en)
Swedish (sv)
Other versions
FI104251B (fi
FI906273A0 (fi
FI906273L (fi
Inventor
Jaswant Singh Gidda
Jill Ann Panetta
Michael Leroy Phillips
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI906273A0 publication Critical patent/FI906273A0/fi
Publication of FI906273L publication Critical patent/FI906273L/fi
Application granted granted Critical
Publication of FI104251B1 publication Critical patent/FI104251B1/fi
Publication of FI104251B publication Critical patent/FI104251B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Surgical Instruments (AREA)
  • Nonmetallic Welding Materials (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Eye Examination Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI906273A 1989-12-21 1990-12-19 Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi FI104251B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45420389A 1989-12-21 1989-12-21
US45420389 1989-12-21

Publications (4)

Publication Number Publication Date
FI906273A0 FI906273A0 (fi) 1990-12-19
FI906273L FI906273L (fi) 1991-06-22
FI104251B1 true FI104251B1 (fi) 1999-12-15
FI104251B FI104251B (fi) 1999-12-15

Family

ID=23803709

Family Applications (2)

Application Number Title Priority Date Filing Date
FI906273A FI104251B (fi) 1989-12-21 1990-12-19 Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi
FI991698A FI19991698L (fi) 1989-12-21 1999-08-10 Menetelmä selektiivisesti eristää, oleellisesti puhtaassa enantiomeerisessä muodossa, raseemisten bentsyylisubstituoitujen rodaniinijohdannaisten enantiomeerejä

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI991698A FI19991698L (fi) 1989-12-21 1999-08-10 Menetelmä selektiivisesti eristää, oleellisesti puhtaassa enantiomeerisessä muodossa, raseemisten bentsyylisubstituoitujen rodaniinijohdannaisten enantiomeerejä

Country Status (22)

Country Link
EP (1) EP0434394B1 (fi)
JP (1) JP3036853B2 (fi)
KR (1) KR0176243B1 (fi)
CN (1) CN1029846C (fi)
AT (1) ATE169294T1 (fi)
AU (1) AU639734B2 (fi)
CA (1) CA2032330C (fi)
CY (1) CY2100B1 (fi)
DE (1) DE69032537T2 (fi)
DK (1) DK0434394T3 (fi)
ES (1) ES2121748T3 (fi)
FI (2) FI104251B (fi)
HU (1) HU216732B (fi)
IE (1) IE904633A1 (fi)
IL (3) IL96654A (fi)
MX (1) MX23803A (fi)
NO (1) NO300458B1 (fi)
NZ (1) NZ236472A (fi)
PT (1) PT96198B (fi)
RU (2) RU2036915C1 (fi)
YU (1) YU240690A (fi)
ZA (1) ZA9010041B (fi)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87339A1 (fr) * 1988-09-20 1990-04-06 Oreal Nouveaux derives de benzylidene-cyclanones,leur procede de preparation,leur utilisation en tant qu'agents anti-oxydants et comme filtres solaires,compositions cosmetiques et pharmaceutiques les contenant
US5143928A (en) * 1990-03-27 1992-09-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
CZ181493A3 (en) * 1992-09-10 1994-03-16 Lilly Co Eli The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease
EP0595546B1 (en) * 1992-10-28 1996-03-20 Shionogi & Co., Ltd. Benzylidene derivatives
US6251928B1 (en) * 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
US5563277A (en) * 1994-12-21 1996-10-08 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
DE69608512T2 (de) * 1995-09-07 2001-01-25 Eli Lilly And Co., Indianapolis Verfahren zur Herstellung von benzylsubstituierten Rhodaninederivaten
PE23298A1 (es) * 1995-09-07 1998-05-05 Lilly Co Eli Forma cristalina alternativa de tazofelona
EP0779282A1 (en) * 1995-12-14 1997-06-18 Eli Lilly And Company Thiomorpholinone compounds for treating multiple sclerosis
US5981523A (en) * 1996-02-05 1999-11-09 Eli Lilly And Company Compounds and methods for treating multiple sclerosis
US5773455A (en) * 1996-06-28 1998-06-30 Biomeasure, Incorporated Inhibitors of prenyl transferases
US6005142A (en) * 1996-09-03 1999-12-21 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
US6063799A (en) * 1996-09-03 2000-05-16 Eli Lilly And Company Alternate crystal form of Tazofelone
WO2000018748A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
WO2000018746A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Thiazolidine derivatives for the treatment and prevention of metabolic bone disorders
US6673816B1 (en) 1998-09-30 2004-01-06 Angelika Esswein Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
US7235573B2 (en) 2002-09-30 2007-06-26 The Regents Of The University Of California Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
AP2005003292A0 (en) * 2002-09-30 2005-06-30 Univ California Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
AU2002953533A0 (en) * 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
JP5778755B2 (ja) * 2010-04-15 2015-09-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ヒドロキノンの製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR862081B (en) * 1985-08-09 1986-12-24 Lilly Co Eli Di-t-butylphenol compounds
IE940525L (en) * 1988-05-25 1989-11-25 Warner Lambert Co Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents
ZA902520B (en) * 1989-04-07 1991-12-24 Lilly Co Eli Aryl-substituted rhodanine derivatives

Also Published As

Publication number Publication date
KR910011812A (ko) 1991-08-07
IL108962A0 (en) 1994-06-24
EP0434394A2 (en) 1991-06-26
YU240690A (sh) 1992-12-21
MX23803A (es) 1994-02-28
PT96198A (pt) 1991-09-30
AU639734B2 (en) 1993-08-05
CY2100B1 (en) 2002-04-05
JP3036853B2 (ja) 2000-04-24
JPH04279573A (ja) 1992-10-05
ES2121748T3 (es) 1998-12-16
NO300458B1 (no) 1997-06-02
DK0434394T3 (da) 1998-12-14
EP0434394A3 (en) 1992-01-08
CN1029846C (zh) 1995-09-27
HU908368D0 (en) 1991-07-29
PT96198B (pt) 1998-05-29
CA2032330C (en) 2001-05-08
HU216732B (hu) 1999-08-30
IL108962A (en) 1996-12-05
FI104251B (fi) 1999-12-15
DE69032537D1 (de) 1998-09-10
NZ236472A (en) 1993-03-26
FI906273A0 (fi) 1990-12-19
FI906273L (fi) 1991-06-22
IL96654A (en) 1995-06-29
CN1052668A (zh) 1991-07-03
FI19991698A7 (fi) 1999-08-10
RU2036915C1 (ru) 1995-06-09
NO905478D0 (no) 1990-12-19
RU2050355C1 (ru) 1995-12-20
DE69032537T2 (de) 1999-01-21
KR0176243B1 (ko) 1999-03-20
EP0434394B1 (en) 1998-08-05
ATE169294T1 (de) 1998-08-15
HUT59915A (en) 1992-07-28
CA2032330A1 (en) 1991-06-22
IE904633A1 (en) 1991-07-17
AU6826690A (en) 1991-06-27
ZA9010041B (en) 1992-08-26
FI19991698L (fi) 1999-08-10
NO905478L (no) 1991-06-24

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: ELI LILLY AND COMPANY