FI104252B1 - Förfarande för kemisk syntes i fast fas av terapeutiskt användbara peptider - Google Patents

Förfarande för kemisk syntes i fast fas av terapeutiskt användbara peptider

Info

Publication number
FI104252B1
FI104252B1 FI911780A FI911780A FI104252B1 FI 104252 B1 FI104252 B1 FI 104252B1 FI 911780 A FI911780 A FI 911780A FI 911780 A FI911780 A FI 911780A FI 104252 B1 FI104252 B1 FI 104252B1
Authority
FI
Finland
Prior art keywords
active site
binding
peptide
receptor
analog
Prior art date
Application number
FI911780A
Other languages
English (en)
Finnish (fi)
Other versions
FI104252B (sv
FI911780A0 (fi
Inventor
David H Coy
Jacques-Pierre Moreau
John E Taylor
Sun Hyuk Kim
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/282,328 external-priority patent/US5162497A/en
Application filed by Univ Tulane filed Critical Univ Tulane
Publication of FI911780A0 publication Critical patent/FI911780A0/fi
Application granted granted Critical
Publication of FI104252B1 publication Critical patent/FI104252B1/sv
Publication of FI104252B publication Critical patent/FI104252B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57572—Gastrin releasing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI911780A 1988-10-14 1991-04-12 Förfarande för kemisk syntes i fast fas av terapeutiskt användbara peptider FI104252B (sv)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US25799888A 1988-10-14 1988-10-14
US25799888 1988-10-14
US28232888 1988-12-09
US07/282,328 US5162497A (en) 1987-09-24 1988-12-09 Bradykinin analogs with non-peptide bond
US31794189A 1989-03-02 1989-03-02
US31794189 1989-03-02
US37655589A 1989-07-07 1989-07-07
US37655589 1989-07-07
US39716989A 1989-08-21 1989-08-21
US39716989 1989-08-21
PCT/US1989/004616 WO1990003980A1 (en) 1988-10-14 1989-10-13 Therapeutic peptides
US8904616 1989-10-13

Publications (3)

Publication Number Publication Date
FI911780A0 FI911780A0 (fi) 1991-04-12
FI104252B1 true FI104252B1 (sv) 1999-12-15
FI104252B FI104252B (sv) 1999-12-15

Family

ID=27540392

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911780A FI104252B (sv) 1988-10-14 1991-04-12 Förfarande för kemisk syntes i fast fas av terapeutiskt användbara peptider

Country Status (12)

Country Link
EP (1) EP0438519B1 (sv)
JP (1) JP2919889B2 (sv)
KR (1) KR900701827A (sv)
AT (1) ATE165836T1 (sv)
AU (1) AU638423B2 (sv)
DE (1) DE68928667T2 (sv)
DK (1) DK66391A (sv)
FI (1) FI104252B (sv)
HU (1) HU208439B (sv)
MC (1) MC2144A1 (sv)
TW (1) TW201754B (sv)
WO (1) WO1990003980A1 (sv)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2877775A (en) * 1957-12-23 1959-03-17 Preston M Hall Rotary type filing and abrading appliance
US5877277A (en) * 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
AU618029B2 (en) * 1987-11-02 1991-12-12 Imperial Chemical Industries Plc Polypeptide compounds
US5830863A (en) * 1988-06-20 1998-11-03 Merrell Pharmaceuticals Inc. Neurokinin A antagonists
US6218364B1 (en) 1988-06-20 2001-04-17 Scott L. Harbeson Fluorinated neurokinin A antagonists
WO1991004040A1 (en) * 1989-09-15 1991-04-04 Biomeasure, Inc. Treatment of colon cancer
IL96216A0 (en) * 1989-11-06 1991-08-16 Erba Carlo Spa Peptide derivatives,their preparation and pharmaceutical compositions containing them
ZA915740B (en) * 1990-07-26 1992-05-27 Merrell Dow Pharma Peptides
US5834433A (en) * 1990-07-26 1998-11-10 Merrell Pharmaceuticals Inc. Compounds and pharmaceutical uses of peptides of bombesin and GRP
US5369094A (en) * 1990-11-29 1994-11-29 The Administrators Of The Tulane Educational Fund Polypeptide bombesin antagonists
US5244883A (en) * 1990-11-29 1993-09-14 The Administrators Of The Tulane Educational Fund Nonapeptide bombesin antagonists
AU659659B2 (en) * 1991-05-23 1995-05-25 Merrell Dow Pharmaceuticals Inc. Bombesin analogs
EP0626973A1 (en) * 1992-02-07 1994-12-07 Merrell Pharmaceuticals Inc. Phenylalanine analogs of bombesin
DE4320201A1 (de) * 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
FR2739553B1 (fr) * 1995-10-06 1998-01-02 Oreal Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
US6156725A (en) * 1996-08-16 2000-12-05 National Institute Of Immunology Drug for the treatment of cancer
US6492330B1 (en) 1996-08-16 2002-12-10 National Institute Of Immunology Antiangiogenic drugs
US8420050B2 (en) 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
NZ564694A (en) 2003-04-22 2009-11-27 Sod Conseils Rech Applic Peptide vectors
JP5603074B2 (ja) * 2006-09-08 2014-10-08 ピラマル イメージング ソシエテ アノニム １８ｆ標識物質のための化合物と方法
JP5799397B2 (ja) 2008-06-12 2015-10-28 イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ 癌の抑制
CA2727082C (en) 2008-06-12 2019-02-26 Syntaxin Limited Fusion proteins for use in suppression of acromegaly
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
EP2198878A1 (en) 2008-12-18 2010-06-23 University Of Miami Polypeptide bombesin antagonists
CN116333041A (zh) * 2023-04-10 2023-06-27 湖南中晟全肽生化有限公司 一种激活grp受体的多肽化合物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207311A (en) * 1977-07-18 1980-06-10 The Salk Institute For Biological Studies Peptides having analgesic and thermoregulative properties
US4331611A (en) 1979-12-21 1982-05-25 International Flavors & Fragrances Inc. Nitrile and uses of same in perfumes, colognes and perfumed articles
US4331661A (en) * 1980-10-03 1982-05-25 The Salk Institute For Biological Studies Bombesin analogs
US4613586A (en) 1984-04-19 1986-09-23 Board Of Trustees Of The Leland Stanford Junior University Gastrin releasing peptide-like peptides
US4803261A (en) * 1986-06-27 1989-02-07 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide

Also Published As

Publication number Publication date
EP0438519A1 (en) 1991-07-31
ATE165836T1 (de) 1998-05-15
HU208439B (en) 1993-10-28
DE68928667T2 (de) 1998-10-01
WO1990003980A1 (en) 1990-04-19
EP0438519B1 (en) 1998-05-06
AU4494989A (en) 1990-05-01
DK66391A (da) 1991-06-14
FI104252B (sv) 1999-12-15
HK1010785A1 (en) 1999-06-25
DE68928667D1 (de) 1998-06-10
KR900701827A (ko) 1990-12-04
EP0438519A4 (en) 1991-10-30
FI911780A0 (fi) 1991-04-12
JP2919889B2 (ja) 1999-07-19
HU896391D0 (en) 1991-07-29
HUT59420A (en) 1992-05-28
AU638423B2 (en) 1993-07-01
TW201754B (sv) 1993-03-11
MC2144A1 (fr) 1992-02-19
JPH04504406A (ja) 1992-08-06
DK66391D0 (da) 1991-04-12

Similar Documents

Publication Publication Date Title
FI104252B1 (sv) Förfarande för kemisk syntes i fast fas av terapeutiskt användbara peptider
NO178306C (no) Analogifremgangsmåte ved fremstilling av bombesin-antagonistpeptid
DK0489089T3 (da) Terapeutiske peptider
NO972930L (no) Fibronectin-adhesjonsinhibitorer
BR9713108A (pt) Colagenase recombinante do tipo i de clostridium histolytucum e o uso da mesma para o isolamento de células e de grupos de células
DE60024092D1 (de) Citrullin-enthaltende fibrin-derivate und ihre verwendung zur diagnose und behandlung von rheumatischer arthritis
DK109280A (da) Tripeptider og fremgangsmaade til fremstilling deraf
LV10108A (lv) Sunu proliferacijas inhibitori farmaceitiska kompozicija savienojumu iegusanas metode sunu proliferacijas inhibesanas panemieni
KR0154528B1 (ko) 항응고성 펩티드
ATE143372T1 (de) Substance p antagoniste
Kiso et al. Neo‐kyotorphin (Thr—Ser—Lys—Tyr—Arg), a new analgesic peptide
Kaur et al. Synthesis and Biological Evaluation of Dehydrophenylalanine Containing Substance P Fragments.
PT93320A (pt) Processo para a preparacao de peptideos terapeuticos
US20100093643A1 (en) Cardioprotective compounds
島村真一 et al. Solution synthesis of a heptacosapeptide known as bovine. GAMMA. 3-melanotropin (. GAMMA. 3-MSH).
CS270617B1 (cs) Analogy enkefalinu á způsob jejich přípravy
CA2244730A1 (en) Anti-inflammatory peptides derived from c-reactive protein