ATE143372T1 - Substance p antagoniste - Google Patents

Substance p antagoniste

Info

Publication number: ATE143372T1
Authority: AT; Austria
Prior art keywords: amino acid; acid residue; peptide; active site; analog
Prior art date: 1989-08-16

Application number

AT90912128T

Other languages

English (en)

Inventor

David H Coy

Jacques-Pierre Moreau

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-16

Filing date

1990-08-16

Publication date

1996-10-15

1990-08-16 Application filed by Univ Tulane filed Critical Univ Tulane

1996-10-15 Application granted granted Critical

1996-10-15 Publication of ATE143372T1 publication Critical patent/ATE143372T1/de

Links

239000003890 substance P antagonist Substances 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 1
102100024304 Protachykinin-1 Human genes 0.000 abstract 1
101800003906 Substance P Proteins 0.000 abstract 1
150000001576 beta-amino acids Chemical class 0.000 abstract 1
229940088623 biologically active substance Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT90912128T 1989-08-16 1990-08-16 Substance p antagoniste ATE143372T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39472789A	1989-08-16	1989-08-16

Publications (1)

Publication Number	Publication Date
ATE143372T1 true ATE143372T1 (de)	1996-10-15

Family

ID=23560172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90912128T ATE143372T1 (de)	1989-08-16	1990-08-16	Substance p antagoniste

Country Status (15)

Country	Link
EP (1)	EP0438566B1 (de)
JP (1)	JPH04502922A (de)
AT (1)	ATE143372T1 (de)
CA (1)	CA2039175A1 (de)
CZ (2)	CZ285319B6 (de)
DD (1)	DD298411A5 (de)
DE (1)	DE69028692T2 (de)
DK (1)	DK0438566T3 (de)
ES (1)	ES2094160T3 (de)
GR (1)	GR900100613A (de)
HU (1)	HUT65465A (de)
IE (1)	IE77033B1 (de)
PT (1)	PT95016B (de)
SK (1)	SK280796B6 (de)
WO (1)	WO1991002745A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5410019A (en) *	1987-09-24	1995-04-25	The Administrators Of The Tulane-Educational Fund	Therapeutic peptides
FR2680174A1 (fr) *	1991-08-05	1993-02-12	Michelot Robert	Nouveaux composes peptidiques, inhibiteurs de l'adsorption du virus hiv sur ses cellules cibles.
DE69231395T3 (de)	1991-09-20	2005-07-21	Glaxo Group Ltd., Greenford	Neue medizinische Indikation für Tachykinin-Antagonisten
US6156725A (en) *	1996-08-16	2000-12-05	National Institute Of Immunology	Drug for the treatment of cancer
US6492330B1 (en)	1996-08-16	2002-12-10	National Institute Of Immunology	Antiangiogenic drugs
EP0835662B1 (de) *	1996-10-08	2001-11-14	National Institute of Immunology	Arzneimittel zur Behandlung von Krebs
CA2225185A1 (en) *	1997-08-11	1999-02-11	Peter K. Law	Myoblast transfer therapy for relieving pain and for treating behavioral and perceptive abnormalities
US6316414B1 (en)	2000-07-31	2001-11-13	Dabur Research Foundation	Somatostatin analogs for the treatment of cancer
EP2117538A1 (de)	2007-01-24	2009-11-18	Glaxo Group Limited	Pharmazeutische zusammensetzungen mit 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
KR20120127390A (ko) *	2009-11-11	2012-11-21	산텐 세이야꾸 가부시키가이샤	소화기 질환 치료제
US9446029B2 (en)	2010-07-27	2016-09-20	Colorado State University Research Foundation	Use of NK-1 receptor antagonists in management of visceral pain
EP4466005A1 (de) *	2022-01-21	2024-11-27	Institut Pasteur De Montevideo	Aktive immunisierung zur verminderung von osteoarthritischen, neuropathischen und krebsschmerzen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3862114A (en) *	1971-11-22	1975-01-21	Ici Australia Ltd	Analogs of substance p
IT1212508B (it) *	1981-12-22	1989-11-22	Anic Spa	Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori
US4481139A (en) *	1983-04-13	1984-11-06	Board Of Regents, The University Of Texas System	Peptide antagonists of substance P
US4803261A (en) *	1986-06-27	1989-02-07	The Administrators Of The Tulane Educational Fund	Method for synthesizing a peptide containing a non-peptide
ZA894533B (en) *	1988-06-20	1990-03-28	Merrell Dow Pharma	Neurokinin a antogonists

1990
- 1990-08-15 IE IE295890A patent/IE77033B1/en not_active IP Right Cessation
- 1990-08-16 HU HU906872A patent/HUT65465A/hu unknown
- 1990-08-16 DK DK90912128.7T patent/DK0438566T3/da active
- 1990-08-16 ES ES90912128T patent/ES2094160T3/es not_active Expired - Lifetime
- 1990-08-16 EP EP90912128A patent/EP0438566B1/de not_active Expired - Lifetime
- 1990-08-16 JP JP2511667A patent/JPH04502922A/ja active Pending
- 1990-08-16 GR GR900100613A patent/GR900100613A/el unknown
- 1990-08-16 CA CA002039175A patent/CA2039175A1/en not_active Abandoned
- 1990-08-16 DD DD90343501A patent/DD298411A5/de not_active IP Right Cessation
- 1990-08-16 CZ CS904028A patent/CZ285319B6/cs not_active IP Right Cessation
- 1990-08-16 SK SK4028-90A patent/SK280796B6/sk unknown
- 1990-08-16 CZ CZ99774A patent/CZ285562B6/cs not_active IP Right Cessation
- 1990-08-16 AT AT90912128T patent/ATE143372T1/de not_active IP Right Cessation
- 1990-08-16 DE DE69028692T patent/DE69028692T2/de not_active Expired - Fee Related
- 1990-08-16 PT PT95016A patent/PT95016B/pt not_active IP Right Cessation
- 1990-08-16 WO PCT/US1990/004633 patent/WO1991002745A1/en not_active Ceased

Also Published As

Publication number	Publication date
IE902958A1 (en)	1991-02-27
JPH04502922A (ja)	1992-05-28
DE69028692T2 (de)	1997-02-20
IE77033B1 (en)	1997-11-19
CZ402890A3 (cs)	1999-04-14
EP0438566A1 (de)	1991-07-31
HUT65465A (en)	1994-06-28
PT95016A (pt)	1991-04-18
ES2094160T3 (es)	1997-01-16
WO1991002745A1 (en)	1991-03-07
EP0438566A4 (en)	1993-03-31
DE69028692D1 (de)	1996-10-31
SK402890A3 (en)	2000-07-11
DK0438566T3 (da)	1996-11-11
DD298411A5 (de)	1992-02-20
EP0438566B1 (de)	1996-09-25
SK280796B6 (sk)	2000-07-11
CA2039175A1 (en)	1991-02-17
PT95016B (pt)	1997-05-28
CZ285319B6 (cs)	1999-07-14
GR900100613A (el)	1991-12-30
CZ285562B6 (cs)	1999-09-15
HU906872D0 (en)	1991-07-29

Legal Events

Date	Code	Title	Description
1997-03-15	UEP	Publication of translation of european patent specification
2006-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE139540T1 (de)	1996-07-15	Heilmittelpeptide
DK249489A (da)	1989-07-20	Therapeutisk virksomme peptider, isaer bombesinantagonistiske og litorinantagonistiske peptider samt fremgangsmaade til fremstilling deraf
DK66391A (da)	1991-06-14	Terapeutisk virksomme peptider
ATE143372T1 (de)	1996-10-15	Substance p antagoniste
DE69011102D1 (de)	1994-09-01	Hydrophobe bindungsstelle für adhäsionspeptide.
ATE189526T1 (de)	2000-02-15	Verfahren zum nachweis von aktiven domänen und aminosäureresten in polypeptiden und hormonvarianten
ES2124685T3 (es)	1999-02-16	Variantes del inhibidor de la tripsina pancreatica bovina, su produccion y uso.
PT1288223E (pt)	2005-03-31	Derivados de peptidos terapeuticos
SE8008428L (sv)	1981-06-04	N-adamantansubstituerade tetrapeptidamider
MX9203175A (es)	1993-04-01	Composicion de implante que contiene un peptido, polipeptido o proteina biologicamente activa y procedimiento para su preparacion.
ES2100960T3 (es)	1997-07-01	Estructura proteica de la toxina vegetal gelonina.
ES2096584T3 (es)	1997-03-16	Polipeptidos y proteinas variantes que poseen afinidad potenciada por matrices de afinidad de metal inmovilizado.
DK450187D0 (da)	1987-08-28	Fremgangsmaade til fremstilling af proteiner
DK1612555T3 (da)	2009-02-09	Kryptiske peptider til anvendelse til at inducere immunologisk tolerance
PT93320A (pt)	1991-10-15	Processo para a preparacao de peptideos terapeuticos
ATE129744T1 (de)	1995-11-15	Rekombinantes c-terminal alpha amidatierungsenzym von menschlischem thyroidursprung.
ATE46173T1 (de)	1989-09-15	Pharmakologisch aktive peptide.
DE3869939D1 (de)	1992-05-14	Biologisch wirksame peptide.
PT95057A (pt)	1991-05-22	Processo para a preparacao de peptidos terapeuticos
IT1274359B (it)	1997-07-17	Peptide sintetico ad attivita' antagonistica per la proteina chemiotattica dei monociti 1 (mcp-1)