FI105068B - Aktiivisia aineita nopeutetusti ja säädetysti vapauttava purukumikoostumus - Google Patents

Aktiivisia aineita nopeutetusti ja säädetysti vapauttava purukumikoostumus Download PDF

Info

Publication number: FI105068B
Authority: FI; Finland
Prior art keywords: chewing gum; gum composition; weight; composition according; active
Prior art date: 1989-07-24

Application number

FI920300A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI920300A0 (fi

Inventor

Carsten Andersen

Morten Pedersen

Original Assignee

Fertin Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-24

Filing date

1992-01-23

Publication date

2000-06-15

1992-01-23 Application filed by Fertin Lab Ltd filed Critical Fertin Lab Ltd

1992-01-23 Publication of FI920300A0 publication Critical patent/FI920300A0/fi

2000-06-15 Application granted granted Critical

2000-06-15 Publication of FI105068B publication Critical patent/FI105068B/fi

Links

229940112822 chewing gum Drugs 0.000 title claims abstract description 144
235000015218 chewing gum Nutrition 0.000 title claims abstract description 144
239000000203 mixture Substances 0.000 title claims abstract description 81
238000013270 controlled release Methods 0.000 title claims abstract description 9
239000002904 solvent Substances 0.000 claims abstract description 63
239000013543 active substance Substances 0.000 claims abstract description 45
229920005989 resin Polymers 0.000 claims abstract description 44
239000011347 resin Substances 0.000 claims abstract description 44
239000000654 additive Substances 0.000 claims abstract description 11
-1 polyethylene acrylate Polymers 0.000 claims description 43
235000014113 dietary fatty acids Nutrition 0.000 claims description 22
239000000194 fatty acid Substances 0.000 claims description 22
229930195729 fatty acid Natural products 0.000 claims description 22
229920001971 elastomer Polymers 0.000 claims description 20
235000003599 food sweetener Nutrition 0.000 claims description 16
239000003765 sweetening agent Substances 0.000 claims description 16
239000000796 flavoring agent Substances 0.000 claims description 14
150000004665 fatty acids Chemical class 0.000 claims description 13
239000003795 chemical substances by application Substances 0.000 claims description 12
239000005060 rubber Substances 0.000 claims description 10
239000002023 wood Substances 0.000 claims description 10
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 9
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
150000003505 terpenes Chemical class 0.000 claims description 9
235000007586 terpenes Nutrition 0.000 claims description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
229920001214 Polysorbate 60 Polymers 0.000 claims description 8
239000003814 drug Substances 0.000 claims description 8
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229940079593 drug Drugs 0.000 claims description 6
229920002689 polyvinyl acetate Polymers 0.000 claims description 6
239000011118 polyvinyl acetate Substances 0.000 claims description 6
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 6
239000007962 solid dispersion Substances 0.000 claims description 6
229920001223 polyethylene glycol Polymers 0.000 claims description 5
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 5
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239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 5
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
239000002202 Polyethylene glycol Substances 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 4
235000019634 flavors Nutrition 0.000 claims description 4
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235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
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SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 3
WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 3
239000001422 FEMA 4092 Substances 0.000 claims description 3
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 3
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229960001948 caffeine Drugs 0.000 claims description 3
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 3
239000004359 castor oil Substances 0.000 claims description 3
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WDRFFJWBUDTUCA-UHFFFAOYSA-N chlorhexidine acetate Chemical compound CC(O)=O.CC(O)=O.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WDRFFJWBUDTUCA-UHFFFAOYSA-N 0.000 claims description 3
229960001884 chlorhexidine diacetate Drugs 0.000 claims description 3
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229960002715 nicotine Drugs 0.000 claims description 3
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WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
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239000001525 mentha piperita l. herb oil Substances 0.000 claims description 2
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239000011710 vitamin D Substances 0.000 claims description 2
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RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims 7
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KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims 7
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical class OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 4
150000002314 glycerols Chemical class 0.000 claims 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 claims 2
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
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WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims 1
PSMFFFUWSMZAPB-UHFFFAOYSA-N Eukalyptol Natural products C1CC2CCC1(C)COCC2(C)C PSMFFFUWSMZAPB-UHFFFAOYSA-N 0.000 claims 1
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DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
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RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 claims 1
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230000001055 chewing effect Effects 0.000 description 17
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229910052804 chromium Inorganic materials 0.000 description 1
239000011651 chromium Substances 0.000 description 1
235000017803 cinnamon Nutrition 0.000 description 1
239000010941 cobalt Substances 0.000 description 1
229910017052 cobalt Inorganic materials 0.000 description 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
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ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
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SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
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239000011737 fluorine Substances 0.000 description 1
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MDQRDWAGHRLBPA-UHFFFAOYSA-N fluoroamine Chemical compound FN MDQRDWAGHRLBPA-UHFFFAOYSA-N 0.000 description 1
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LCWMKIHBLJLORW-UHFFFAOYSA-N gamma-carene Natural products C1CC(=C)CC2C(C)(C)C21 LCWMKIHBLJLORW-UHFFFAOYSA-N 0.000 description 1
238000007429 general method Methods 0.000 description 1
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IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
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235000012907 honey Nutrition 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
239000008172 hydrogenated vegetable oil Substances 0.000 description 1
150000002433 hydrophilic molecules Chemical class 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
XSEOYPMPHHCUBN-FGYWBSQSSA-N hydroxylated lecithin Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCC[C@@H](O)[C@H](O)CCCCCCCC XSEOYPMPHHCUBN-FGYWBSQSSA-N 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
239000011630 iodine Substances 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
150000003903 lactic acid esters Chemical class 0.000 description 1
239000000832 lactitol Substances 0.000 description 1
235000010448 lactitol Nutrition 0.000 description 1
VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
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239000011133 lead Substances 0.000 description 1
229940010454 licorice Drugs 0.000 description 1
235000001510 limonene Nutrition 0.000 description 1
229940087305 limonene Drugs 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
235000011160 magnesium carbonates Nutrition 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
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229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
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235000010981 methylcellulose Nutrition 0.000 description 1
239000004200 microcrystalline wax Substances 0.000 description 1
235000019808 microcrystalline wax Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
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239000000978 natural dye Substances 0.000 description 1
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239000011664 nicotinic acid Substances 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
229940126701 oral medication Drugs 0.000 description 1
229940090668 parachlorophenol Drugs 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
239000012169 petroleum derived wax Substances 0.000 description 1
235000019381 petroleum wax Nutrition 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
229960005323 phenoxyethanol Drugs 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
239000008055 phosphate buffer solution Substances 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
229960000502 poloxamer Drugs 0.000 description 1
239000008389 polyethoxylated castor oil Substances 0.000 description 1
239000003996 polyglycerol polyricinoleate Substances 0.000 description 1
235000010958 polyglycerol polyricinoleate Nutrition 0.000 description 1
239000002952 polymeric resin Substances 0.000 description 1
229960004054 polynoxylin Drugs 0.000 description 1
ODGAOXROABLFNM-UHFFFAOYSA-N polynoxylin Polymers O=C.NC(N)=O ODGAOXROABLFNM-UHFFFAOYSA-N 0.000 description 1
235000011185 polyoxyethylene (40) stearate Nutrition 0.000 description 1
239000001194 polyoxyethylene (40) stearate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
239000000770 propane-1,2-diol alginate Substances 0.000 description 1
239000000473 propyl gallate Substances 0.000 description 1
235000010388 propyl gallate Nutrition 0.000 description 1
229940075579 propyl gallate Drugs 0.000 description 1
229960004063 propylene glycol Drugs 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
GRWFGVWFFZKLTI-UHFFFAOYSA-N rac-alpha-Pinene Natural products CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 description 1
239000002994 raw material Substances 0.000 description 1
238000007670 refining Methods 0.000 description 1
235000019192 riboflavin Nutrition 0.000 description 1
239000002151 riboflavin Substances 0.000 description 1
239000004170 rice bran wax Substances 0.000 description 1
235000019384 rice bran wax Nutrition 0.000 description 1
WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical class OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 description 1
208000026451 salivation Diseases 0.000 description 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
238000012216 screening Methods 0.000 description 1
235000019613 sensory perceptions of taste Nutrition 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
150000003378 silver Chemical class 0.000 description 1
LKZMBDSASOBTPN-UHFFFAOYSA-L silver carbonate Substances [Ag].[O-]C([O-])=O LKZMBDSASOBTPN-UHFFFAOYSA-L 0.000 description 1
229910001958 silver carbonate Inorganic materials 0.000 description 1
229910001961 silver nitrate Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229960004711 sodium monofluorophosphate Drugs 0.000 description 1
ODFAPIRLUPAQCQ-UHFFFAOYSA-M sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 description 1
229940080352 sodium stearoyl lactylate Drugs 0.000 description 1
235000010956 sodium stearoyl-2-lactylate Nutrition 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
KNYAZNABVSEZDS-UHFFFAOYSA-M sodium;2-octadecanoyloxypropanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C([O-])=O KNYAZNABVSEZDS-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
229940013618 stevioside Drugs 0.000 description 1
OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
235000019202 steviosides Nutrition 0.000 description 1
239000003351 stiffener Substances 0.000 description 1
229910052712 strontium Inorganic materials 0.000 description 1
CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
229920003048 styrene butadiene rubber Polymers 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000000979 synthetic dye Substances 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
230000035923 taste sensation Effects 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000010257 thawing Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
229960000790 thymol Drugs 0.000 description 1
YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
235000019149 tocopherols Nutrition 0.000 description 1
229940024986 topical antifungal imidazole and triazole derivative Drugs 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229960003500 triclosan Drugs 0.000 description 1
ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical class C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
229910052720 vanadium Inorganic materials 0.000 description 1
GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019163 vitamin B12 Nutrition 0.000 description 1
239000011715 vitamin B12 Substances 0.000 description 1
235000019164 vitamin B2 Nutrition 0.000 description 1
239000011716 vitamin B2 Substances 0.000 description 1
235000019168 vitamin K Nutrition 0.000 description 1
239000011712 vitamin K Substances 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000004246 zinc acetate Substances 0.000 description 1
235000013904 zinc acetate Nutrition 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
239000011670 zinc gluconate Substances 0.000 description 1
235000011478 zinc gluconate Nutrition 0.000 description 1
229960000306 zinc gluconate Drugs 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/02—Apparatus specially adapted for manufacture or treatment of chewing gum
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/08—Chewing gum characterised by the composition containing organic or inorganic compounds of the chewing gum base
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Inorganic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Confectionery (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Circuits Of Receivers In General (AREA)
Telephonic Communication Services (AREA)
Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)

FI920300A 1989-07-24 1992-01-23 Aktiivisia aineita nopeutetusti ja säädetysti vapauttava purukumikoostumus FI105068B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK365389		1989-07-24
DK365389A DK365389D0 (da)	1989-07-24	1989-07-24	Antifungalt tyggegummipraeparat
DK9000189		1990-07-18
PCT/DK1990/000189 WO1991001132A1 (fr)	1989-07-24	1990-07-18	Composition de chewing-gum a liberation reglee et acceleree des agents actifs

Publications (2)

Publication Number	Publication Date
FI920300A0 FI920300A0 (fi)	1992-01-23
FI105068B true FI105068B (fi)	2000-06-15

Family

ID=8125297

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FI920300A FI105068B (fi)	1989-07-24	1992-01-23	Aktiivisia aineita nopeutetusti ja säädetysti vapauttava purukumikoostumus
FI990251A FI105527B (fi)	1989-07-24	1999-02-09	Menetelmä purukumikoostumuksen valmistamiseksi

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
FI990251A FI105527B (fi)	1989-07-24	1999-02-09	Menetelmä purukumikoostumuksen valmistamiseksi

Country Status (16)

Country	Link
US (1)	US5487902A (fr)
EP (1)	EP0486563B1 (fr)
KR (1)	KR0185574B1 (fr)
AT (1)	ATE94059T1 (fr)
AU (1)	AU637815B2 (fr)
CA (1)	CA2063819C (fr)
DE (1)	DE69003244T2 (fr)
DK (2)	DK365389D0 (fr)
ES (1)	ES2058929T3 (fr)
FI (2)	FI105068B (fr)
GR (1)	GR900100562A (fr)
IE (1)	IE64838B1 (fr)
NO (2)	NO304407B1 (fr)
PT (1)	PT94801B (fr)
WO (1)	WO1991001132A1 (fr)
ZA (1)	ZA905722B (fr)

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1989
- 1989-07-24 DK DK365389A patent/DK365389D0/da not_active Application Discontinuation
1990
- 1990-07-18 AT AT90912237T patent/ATE94059T1/de not_active IP Right Cessation
- 1990-07-18 AU AU61621/90A patent/AU637815B2/en not_active Ceased
- 1990-07-18 ES ES90912237T patent/ES2058929T3/es not_active Expired - Lifetime
- 1990-07-18 DE DE90912237T patent/DE69003244T2/de not_active Expired - Fee Related
- 1990-07-18 CA CA002063819A patent/CA2063819C/fr not_active Expired - Lifetime
- 1990-07-18 WO PCT/DK1990/000189 patent/WO1991001132A1/fr not_active Ceased
- 1990-07-18 EP EP90912237A patent/EP0486563B1/fr not_active Expired - Lifetime
- 1990-07-18 KR KR1019920700175A patent/KR0185574B1/ko not_active Expired - Fee Related
- 1990-07-18 DK DK90912237.6T patent/DK0486563T3/da active
- 1990-07-20 ZA ZA905722A patent/ZA905722B/xx unknown
- 1990-07-23 GR GR900100562A patent/GR900100562A/el not_active IP Right Cessation
- 1990-07-23 IE IE267290A patent/IE64838B1/en not_active IP Right Cessation
- 1990-07-24 PT PT94801A patent/PT94801B/pt not_active IP Right Cessation
1992
- 1992-01-23 NO NO920317A patent/NO304407B1/no not_active IP Right Cessation
- 1992-01-23 FI FI920300A patent/FI105068B/fi active
1994
- 1994-09-19 US US08/308,620 patent/US5487902A/en not_active Expired - Lifetime
1998
- 1998-08-18 NO NO983771A patent/NO309672B1/no not_active IP Right Cessation
1999
- 1999-02-09 FI FI990251A patent/FI105527B/fi active

Also Published As

Publication number	Publication date
ES2058929T3 (es)	1994-11-01
NO920317L (no)	1992-03-23
AU637815B2 (en)	1993-06-10
ATE94059T1 (de)	1993-09-15
FI105527B (fi)	2000-09-15
FI990251A0 (fi)	1999-02-09
FI990251L (fi)	1999-02-09
IE64838B1 (en)	1995-09-06
NO983771D0 (no)	1998-08-18
EP0486563A1 (fr)	1992-05-27
GR900100562A (el)	1991-12-10
KR0185574B1 (ko)	1999-03-20
DE69003244T2 (de)	1994-01-05
DK0486563T3 (da)	1993-11-29
NO920317D0 (no)	1992-01-23
PT94801B (pt)	1997-03-31
NO309672B1 (no)	2001-03-12
DK365389D0 (da)	1989-07-24
CA2063819C (fr)	2000-02-22
CA2063819A1 (fr)	1991-01-25
WO1991001132A1 (fr)	1991-02-07
US5487902A (en)	1996-01-30
AU6162190A (en)	1991-02-22
EP0486563B1 (fr)	1993-09-08
PT94801A (pt)	1991-03-20
NO304407B1 (no)	1998-12-14
NO983771L (no)	1998-08-18
FI920300A0 (fi)	1992-01-23
DE69003244D1 (de)	1993-10-14
IE902672A1 (en)	1991-02-27
ZA905722B (en)	1991-04-24

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